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Cldn11 Gene Detail
Summary
  • Symbol
    Cldn11
  • Name
    claudin 11
  • Synonyms
    oligodendrocyte-specific protein, Osp, Otm
  • Feature Type
    protein coding gene
  • IDs
    MGI:106925
    NCBI Gene: 18417
  • Gene Overview
    MyGene.info: CLDN11
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:31149920-31164324 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 15.14 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    36 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106925
protein coding gene Chr3:31149920-31164326 (.)
129S1/SvImJ MGP_129S1SvImJ_G0027132
protein coding gene Chr3:28678017-28693270 (+)
A/J MGP_AJ_G0027092
protein coding gene Chr3:28299656-28314724 (+)
AKR/J MGP_AKRJ_G0027061
protein coding gene Chr3:28733347-28749512 (+)
BALB/cJ MGP_BALBcJ_G0027104
protein coding gene Chr3:27984813-27999957 (+)
C3H/HeJ MGP_C3HHeJ_G0026846
protein coding gene Chr3:28748321-28771208 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027550
protein coding gene Chr3:30196772-30215504 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024911
protein coding gene Chr3:26200451-26214525 (+)
CAST/EiJ MGP_CASTEiJ_G0026300
protein coding gene Chr3:28673764-28691246 (+)
CBA/J MGP_CBAJ_G0026824
protein coding gene Chr3:30956321-30970723 (+)
DBA/2J MGP_DBA2J_G0026958
protein coding gene Chr3:27844541-27858970 (+)
FVB/NJ MGP_FVBNJ_G0026926
protein coding gene Chr3:27293078-27307612 (+)
LP/J MGP_LPJ_G0027069
protein coding gene Chr3:29374477-29402814 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026946
protein coding gene Chr3:33535204-33549938 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027609
protein coding gene Chr3:28512943-28528865 (+)
PWK/PhJ MGP_PWKPhJ_G0026033
protein coding gene Chr3:27363277-27378336 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025845
protein coding gene Chr3:27999456-28014937 (+)
WSB/EiJ MGP_WSBEiJ_G0026374
protein coding gene Chr3:28573523-28593784 (+)



Homology
more
  • Human Ortholog
    CLDN11, claudin 11
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CLDN11, claudin 11
    Orthology source: HomoloGene, HGNC
  • Synonyms
    OSP, OTM
  • Links
    NCBI Gene ID: 5010
    neXtProt AC: NX_O75508
    UniProt: O75508

  • Chr Location
    3q26.2; chr3:170418865-170434691 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 4093
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CLDN11
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit tremors, impaired coordination, hindlimb weakness, abnormal myelination of the cranial nerves, increased auditory thresholds, and abnormal stria vascularis. Mutant males have small testes, abnormal seminiferous tubules, and sperm abnormalities resulting in infertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037625 Ensembl Gene Model | MGI Sequence Detail 14405 C57BL/6J ±  kb
    transcript ENSMUST00000046174 Ensembl | MGI Sequence Detail 1870 Not Applicable  
    polypeptide ENSMUSP00000042181 Ensembl | MGI Sequence Detail 207 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      cDNA 23
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-35386
    References
    more
    • Summaries
      All 76
      Developmental Gene Expression 29
      Diseases 1
      Gene Ontology 9
      Phenotypes 11
    • Earliest
      J:33372 Bronstein JM, et al., Chromosomal localization of murine and human oligodendrocyte-specific protein genes. Genomics. 1996 Jun 1;34(2):255-7
    • Latest
      J:262559 Maheras KJ, et al., Absence of Claudin 11 in CNS Myelin Perturbs Behavior and Neurotransmitter Levels in Mice. Sci Rep. 2018 Feb 28;8(1):3798

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory