About   Help   FAQ
Cldn11
Gene Detail
Symbol

Name
ID
Cldn11
claudin 11
MGI:106925
Synonyms
oligodendrocyte-specific protein, Osp, Otm
Feature Type
protein coding gene
Genetic Map
Chromosome 3
15.14 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr3:31149920-31164324 bp, + strand
From VEGA annotation of GRCm38

  14405 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4093  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CLDN11
Gene Tree: Cldn11

Human
homologs
CLDN11, claudin 11
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5010
neXtProt AC: NX_O75508

Human Synonyms: OSP, OTM

Human Chr (Location): 3q26.2-q26.3; chr3:170418865-170434691 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
 
Homozygous null mice exhibit tremors, impaired coordination, hindlimb weakness, abnormal myelination of the cranial nerves, increased auditory thresholds, and abnormal stria vascularis. Mutant males have small testes, abnormal seminiferous tubules, and sperm abnormalities resulting in infertility.
 
Interactions
Cldn11 interacts with 149 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process axon ensheathment, cell adhesion, ...
Component basal part of cell, bicellular tight junction, ...
Function protein binding, structural molecule activity
External Resources: FuncBase
Expression
Literature Summary: (18 records)
Data Summary: Results (223)    Tissues (43)    Images (40)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 15
RNA in situ 200
Western blot 1
RT-PCR 7
cDNA source data(20)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA CLDN11 ; Xenbase cldn11 ; ZFIN cldn11a, cldn11b    NEW 
Molecular
reagents
All nucleic(23) cDNA(20) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000022650 (Evidence)
Ensembl Gene Model ENSMUSG00000037625 (Evidence)
Entrez Gene 18417 (Evidence)
UniGene 4425
DFCI TC1575973
DoTS DT.55100737
NIA Mouse Gene Index U003118
Consensus CDS Project CCDS17290.1
International Mouse Phenotyping Consortium Status Cldn11
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022650 VEGA Gene Model | MGI Sequence Detail 14405 C57BL/6J ±  kb
transcript OTTMUST00000054268 VEGA | MGI Sequence Detail 1870 Not Applicable 
polypeptide OTTMUSP00000025883 VEGA | MGI Sequence Detail 207 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(1)
Polymorphisms
RFLP(2) : SNPs within 2kb(36 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006187 Claudin
InterPro IPR003555 Claudin-11
InterPro IPR017974 Claudin, conserved site
InterPro IPR004031 PMP-22/EMP/MP20/Claudin
Protein Ontology PR:000005539 claudin-11
References
(Earliest) J:33372 Bronstein JM, et al., Chromosomal localization of murine and human oligodendrocyte-specific protein genes. Genomics. 1996 Jun 1;34(2):255-7
(Latest) J:205383 Salti A, et al., Expression of early developmental markers predicts the efficiency of embryonic stem cell differentiation into midbrain dopaminergic neurons. Stem Cells Dev. 2013 Feb 1;22(3):397-411
All references(65)
Other
accession IDs
MGD-MRK-35386

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/23/2015
MGI 5.22
The Jackson Laboratory