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Vdac3 Gene Detail
Summary
  • Symbol
    Vdac3
  • Name
    voltage-dependent anion channel 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:106922
    NCBI Gene: 22335
  • Gene Overview
    MyGene.info: VDAC3
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:22577075-22593813 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 11.42 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106922
protein coding gene Chr8:22577075-22593813 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033454
protein coding gene Chr8:20429242-20447832 (-)
A/J MGP_AJ_G0033434
protein coding gene Chr8:19765061-19784160 (-)
AKR/J MGP_AKRJ_G0033359
protein coding gene Chr8:20416285-20432592 (-)
BALB/cJ MGP_BALBcJ_G0033430
protein coding gene Chr8:19888478-19906662 (-)
C3H/HeJ MGP_C3HHeJ_G0033144
protein coding gene Chr8:20612748-20632236 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033946
protein coding gene Chr8:21290758-21315051 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030899
protein coding gene Chr8:17095872-17111740 (-)
CAST/EiJ MGP_CASTEiJ_G0032470
protein coding gene Chr8:20029189-20047250 (-)
CBA/J MGP_CBAJ_G0033119
protein coding gene Chr8:22141471-22165068 (-)
DBA/2J MGP_DBA2J_G0033274
protein coding gene Chr8:19732590-19750077 (-)
FVB/NJ MGP_FVBNJ_G0033218
protein coding gene Chr8:19525634-19548593 (-)
LP/J MGP_LPJ_G0033363
protein coding gene Chr8:20426082-20443951 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033261
protein coding gene Chr8:21725364-21762032 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033965
protein coding gene Chr8:20318763-20337297 (-)
PWK/PhJ MGP_PWKPhJ_G0032182
protein coding gene Chr8:19320916-19337768 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032015
protein coding gene Chr8:19705334-19722130 (-)
WSB/EiJ MGP_WSBEiJ_G0032586
protein coding gene Chr8:20518572-20537739 (-)



Homology
more
  • Human Ortholog
    VDAC3, voltage dependent anion channel 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    VDAC3, voltage dependent anion channel 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HD-VDAC3, VDAC-3
  • Links
    NCBI Gene ID: 7419
    neXtProt AC: NX_Q9Y277
    UniProt: Q9Y277

  • Chr Location
    8p11.21; chr8:42391624-42405937 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 1 allele in 1 genetic background
    6 phenotypes from multigenic genotypes
    3 images
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mutants are male sterile with reduced sperm motility and structural defects in the majority of axonemes in epididymal sperm. Mutants of both genders show deficits in behavioral tests measuring contextual or cued fear conditioning.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 22335 NCBI Gene Model | MGI Sequence Detail 16739 C57BL/6J ±  kb
transcript NM_001198998 RefSeq | MGI Sequence Detail 1423 C57BL/6  
polypeptide Q60931 UniProt | EBI | MGI Sequence Detail 283 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    6 Sequences
  • InterPro Domains
    IPR027246 Eukaryotic porin/Tom40
    IPR023614 Porin domain superfamily
    IPR001925 Porin, eukaryotic type
    IPR030271 Voltage-dependent anion-selective channel protein 3
Molecular
Reagents
less
  • All nucleic 243
    Genomic 3
    cDNA 240

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-35383
References
more
  • Summaries
    All 45
    Gene Ontology 9
    Phenotypes 13
  • Earliest
    J:34931 Sampson MJ, et al., A novel mouse mitochondrial voltage-dependent anion channel gene localizes to chromosome 8. Genomics. 1996 Aug 15;36(1):192-6
  • Latest
    J:257115 Zou L, et al., Knockout of mitochondrial voltage-dependent anion channel type 3 increases reactive oxygen species (ROS) levels and alters renal sodium transport. J Biol Chem. 2018 Feb 2;293(5):1666-1675

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory