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Vdac3 Gene Detail
Summary
  • Symbol
    Vdac3
  • Name
    voltage-dependent anion channel 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:106922
    NCBI Gene: 22335
  • Gene Overview
    MyGene.info: VDAC3
Location & Maps
more
  • Sequence Map
    Chr8:22577086-22593758 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      16673 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 11.42 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    VDAC3, voltage dependent anion channel 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    VDAC3, voltage dependent anion channel 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HD-VDAC3, VDAC-3
  • Links
    NCBI Gene ID: 7419
    neXtProt AC: NX_Q9Y277

  • Chr Location
    8p11.2; chr8:42391624-42405937 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 1 allele in 1 genetic background
    6 phenotypes from multigenic genotypes
    3 images
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants are male sterile with reduced sperm motility and structural defects in the majority of axonemes in epididymal sperm. Mutants of both genders show deficits in behavioral tests measuring contextual or cued fear conditioning.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000060891 VEGA Gene Model | MGI Sequence Detail 16673 C57BL/6J ±  kb
transcript OTTMUST00000148811 VEGA | MGI Sequence Detail 1354 Not Applicable  
polypeptide OTTMUSP00000077308 VEGA | MGI Sequence Detail 283 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    2 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000017282 voltage-dependent anion-selective channel protein 3
  • InterPro Domains
    IPR027246 Eukaryotic porin/Tom40
    IPR023614 Porin domain
    IPR001925 Porin, eukaryotic type
    IPR030271 Voltage-dependent anion-selective channel protein 3
Molecular
Reagents
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  • All nucleic 242
    Genomic 3
    cDNA 239

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-35383
References
more
  • Summaries
    All 43
    Gene Ontology 9
    Phenotypes 12
  • Earliest
    J:34931 Sampson MJ, et al., A novel mouse mitochondrial voltage-dependent anion channel gene localizes to chromosome 8. Genomics. 1996 Aug 15;36(1):192-6
  • Latest
    J:192731 Ha SD, et al., Cellular adaptation to anthrax lethal toxin-induced mitochondrial cholesterol enrichment, hyperpolarization, and reactive oxygen species generation through downregulating MLN64 in macrophages. Mol Cell Biol. 2012 Dec;32(23):4846-60

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory