About   Help   FAQ
Vdac3
Gene Detail
Symbol

Name
ID
Vdac3
voltage-dependent anion channel 3
MGI:106922
Feature Type
protein coding gene
Genetic Map
Chromosome 8
11.42 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:22577075-22593813 bp, - strand
From NCBI annotation of GRCm38

  16739 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:36115  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: porin
Gene Tree: Vdac3

Human
homologs
Human Homolog VDAC3, voltage-dependent anion channel 3
NCBI Gene ID 7419
neXtProt AC  NX_Q9Y277
Human Synonyms  HD-VDAC3, VDAC-3
Human Chr (Location)  8p11.2; chr8:42391624-42405937 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(20) : Gene trapped(18) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants are male sterile with reduced sperm motility and structural defects in the majority of axonemes in epididymal sperm. Mutants of both genders show deficits in behavioral tests measuring contextual or cued fear conditioning.
 
Phenotype Images(3)
Interactions
Vdac3 interacts with 106 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process anion transport, behavioral fear response, ...
Component extracellular vesicular exosome, integral component of membrane, ...
Function nucleotide binding, porin activity, ...
External Resources: FuncBase
Expression
cDNA source data(239)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(242) Genomic(3) cDNA(239)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000008892 (Evidence)
Entrez Gene22335 (Evidence)
UniGene227704
DFCITC1573194
DoTSDT.40179015, DT.101240120
NIA Mouse Gene IndexU029637, U060673, U080794
Consensus CDS ProjectCCDS22179.1
International Mouse Knockout Project StatusVdac3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 22335 NCBI Gene Model | MGI Sequence Detail 16739 C57BL/6J ±  kb
transcript NM_001198998 RefSeq | MGI Sequence Detail 1423 C57BL/6 
polypeptide Q60931 UniProt | EBI | MGI Sequence Detail 283 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(4) UniProt(11)
Polymorphisms
RFLP(1) : SNPs within 2kb(2 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027246 Eukaryotic porin/Tom40
InterPro IPR023614 Porin domain
InterPro IPR001925 Porin, eukaryotic type
Protein Ontology PR:000017282 voltage-dependent anion-selective channel protein 3
Graphical View of Protein Domain Structure
References
(Earliest) J:34931 Sampson MJ, et al., A novel mouse mitochondrial voltage-dependent anion channel gene localizes to chromosome 8. Genomics. 1996 Aug 15;36(1):192-6
(Latest) J:192731 Ha SD, et al., Cellular adaptation to anthrax lethal toxin-induced mitochondrial cholesterol enrichment, hyperpolarization, and reactive oxygen species generation through downregulating MLN64 in macrophages. Mol Cell Biol. 2012 Dec;32(23):4846-60
All references(47)
Other
accession IDs
MGD-MRK-35383

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/16/2014
MGI 5.20
The Jackson Laboratory