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Scn2b Gene Detail
Summary
  • Symbol
    Scn2b
  • Name
    sodium channel, voltage-gated, type II, beta
  • Synonyms
    2810451E09Rik, LOC214238
  • Feature Type
    protein coding gene
  • IDs
    MGI:106921
    NCBI Gene: 72821
  • Gene Overview
    MyGene.info: SCN2B
Location & Maps
more
  • Sequence Map
    Chr9:45117876-45130070 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      12195 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    SCN2B, sodium voltage-gated channel beta subunit 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SCN2B, sodium voltage-gated channel beta subunit 2
    Orthology source: HomoloGene
  • Synonyms
    ATFB14
  • Links
    NCBI Gene ID: 6327
    neXtProt AC: NX_O60939

  • Chr Location
    11q23; chr11:118162804-118176622 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 3373
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: SCN2B
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human SCN2B associations

Human Disease Mouse Models
       Atrial Fibrillation, Familial, 14; ATFB14   OMIM: 615378
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Gene trapped
    2
  • Targeted
    2
  • Incidental Mutations
    APF
Mice homozygous for a knock-out allele display decreased sodium channel density, altered voltage dependence of inactivation, and increased susceptibility to pilocarpine-induced seizures but appear normal in other neurological tests.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 72821 NCBI Gene Model | MGI Sequence Detail 12195 C57BL/6J ±  kb
transcript NM_001014761 RefSeq | MGI Sequence Detail 4562 C57BL/6  
polypeptide Q56A07 UniProt | EBI | MGI Sequence Detail 215 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    117 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
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  • All nucleic 7
    cDNA 7

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-35382, MGI:1920071, MGI:2143131, MGI:2685029
References
more
  • Summaries
    All 38
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 13
  • Earliest
    J:45864 Isom LL, et al., Structure and function of the beta 2 subunit of brain sodium channels, a transmembrane glycoprotein with a CAM motif. Cell. 1995 Nov 3;83(3):433-42
  • Latest
    J:170564 Kim DY, et al., Reduced sodium channel Na(v)1.1 levels in BACE1-null mice. J Biol Chem. 2011 Mar 11;286(10):8106-16

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory