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Scn2b
Gene Detail
 Symbol
Name
ID
Scn2b
sodium channel, voltage-gated, type II, beta
MGI:106921
Synonyms 2810451E09Rik, LOC214238
Feature Type protein coding gene
Genetic Map
Chromosome 9
24.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr9:45117876-45130070 bp, + strand
From NCBI annotation of GRCm38

  12195 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3373  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Scn2b

Human
homologs
Human Homolog SCN2B, sodium channel, voltage-gated, type II, beta subunit
NCBI Gene ID 6327
neXtProt AC  NX_O60939
Human Synonyms  ATFB14
Human Chr (Location)  11q23; chr11:118162804-118176622 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human SCN2B
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(2) Targeted(2)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out allele display decreased sodium channel density, altered voltage dependence of inactivation, and increased susceptibility to pilocarpine-induced seizures but appear normal in other neurological tests.
 
Interactions
Scn2b interacts with 316 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process cardiac muscle cell action potential involved in contraction, cardiac muscle contraction, ...
Component integral component of membrane, membrane, ...
Function sodium channel activity, sodium channel regulator activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (23)    Tissues (7)    Images (13)
Theiler Stages: 11, 13, 23
Assay TypeResults
RNA in situ 23
cDNA source data(6)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(7) cDNA(7)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000070304 (Evidence)
Entrez Gene72821 (Evidence)
DFCITC1587813, TC1602944
DoTSDT.50315760, DT.55139534
NIA Mouse Gene IndexU010411
Consensus CDS ProjectCCDS40606.1
International Mouse Knockout Project StatusScn2b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 72821 NCBI Gene Model | MGI Sequence Detail 12195 C57BL/6J ±  kb
transcript NM_001014761 RefSeq | MGI Sequence Detail 4562 C57BL/6 
polypeptide Q56A07 UniProt | EBI | MGI Sequence Detail 215 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(6) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(119 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR013106 Immunoglobulin V-set
InterPro IPR000920 Myelin P0 protein
Protein Ontology PR:000014523 sodium channel subunit beta-2
Graphical View of Protein Domain Structure
References (Earliest) J:45864 Isom LL, et al., Structure and function of the beta 2 subunit of brain sodium channels, a transmembrane glycoprotein with a CAM motif. Cell. 1995 Nov 3;83(3):433-42
(Latest) J:170564 Kim DY, et al., Reduced sodium channel Na(v)1.1 levels in BACE1-null mice. J Biol Chem. 2011 Mar 11;286(10):8106-16
All references(43)
Other
accession IDs
MGD-MRK-35382, MGI:1920071, MGI:2143131, MGI:2685029

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory