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Scn2b
Gene Detail
Symbol

Name
ID
Scn2b
sodium channel, voltage-gated, type II, beta
MGI:106921
Synonyms
2810451E09Rik, LOC214238
Feature Type
protein coding gene
Genetic Map
Chromosome 9
24.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr9:45117876-45130070 bp, + strand
From NCBI annotation of GRCm38

  12195 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3373  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SCN2B
Gene Tree: Scn2b

Human
homologs
SCN2B, sodium channel, voltage gated, type II beta subunit
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 6327
neXtProt AC: NX_O60939

Human Synonyms: ATFB14

Human Chr (Location): 11q23; chr11:118162804-118176622 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human SCN2B

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(2) Targeted(2)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out allele display decreased sodium channel density, altered voltage dependence of inactivation, and increased susceptibility to pilocarpine-induced seizures but appear normal in other neurological tests.
 
Interactions
Scn2b interacts with 315 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (23)    Tissues (7)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 23
cDNA source data(6)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase scn2b ; ZFIN scn2b    NEW 
Molecular
reagents
All nucleic(7) cDNA(7)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000070304 (Evidence)
Entrez Gene 72821 (Evidence)
DFCI TC1587813, TC1602944
DoTS DT.50315760, DT.55139534
NIA Mouse Gene Index U010411
Consensus CDS Project CCDS40606.1
International Mouse Phenotyping Consortium Status Scn2b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 72821 NCBI Gene Model | MGI Sequence Detail 12195 C57BL/6J ±  kb
transcript NM_001014761 RefSeq | MGI Sequence Detail 4562 C57BL/6 
polypeptide Q56A07 UniProt | EBI | MGI Sequence Detail 215 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(6) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(119 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR013106 Immunoglobulin V-set domain
InterPro IPR000920 Myelin P0 protein-related
InterPro IPR029873 Sodium channel subunit beta-2
Protein Ontology PR:000014523 sodium channel subunit beta-2
Graphical View of Protein Domain Structure
References
(Earliest) J:45864 Isom LL, et al., Structure and function of the beta 2 subunit of brain sodium channels, a transmembrane glycoprotein with a CAM motif. Cell. 1995 Nov 3;83(3):433-42
(Latest) J:170564 Kim DY, et al., Reduced sodium channel Na(v)1.1 levels in BACE1-null mice. J Biol Chem. 2011 Mar 11;286(10):8106-16
All references(41)
Other
accession IDs
MGD-MRK-35382, MGI:1920071, MGI:2143131, MGI:2685029

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory