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Scn2b Gene Detail
Summary
  • Symbol
    Scn2b
  • Name
    sodium channel, voltage-gated, type II, beta
  • Synonyms
    2810451E09Rik, LOC214238
  • Feature Type
    protein coding gene
  • IDs
    MGI:106921
    NCBI Gene: 72821
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:45029174-45041368 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 9, 24.84 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    117 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106921
protein coding gene Chr9:45029080-45041368 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034731
protein coding gene Chr9:43660790-43674797 (+)
A/J MGP_AJ_G0034712
protein coding gene Chr9:42443395-42456376 (+)
AKR/J MGP_AKRJ_G0034639
protein coding gene Chr9:43319187-43330508 (+)
BALB/cJ MGP_BALBcJ_G0034703
protein coding gene Chr9:42176920-42189769 (+)
C3H/HeJ MGP_C3HHeJ_G0034414
protein coding gene Chr9:43773470-43787339 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035224
protein coding gene Chr9:44937739-44952797 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032138
protein coding gene Chr9:41995227-42007480 (+)
CAST/EiJ MGP_CASTEiJ_G0033736
protein coding gene Chr9:43634076-43646258 (+)
CBA/J MGP_CBAJ_G0034386
protein coding gene Chr9:46590890-46603076 (+)
DBA/2J MGP_DBA2J_G0034545
protein coding gene Chr9:42332442-42344640 (+)
FVB/NJ MGP_FVBNJ_G0034486
protein coding gene Chr9:41590641-41601921 (+)
LP/J MGP_LPJ_G0034626
protein coding gene Chr9:43959792-43972500 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034530
protein coding gene Chr9:48412318-48424557 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035245
protein coding gene Chr9:43237761-43250643 (+)
PWK/PhJ MGP_PWKPhJ_G0033441
protein coding gene Chr9:42219183-42232110 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033277
protein coding gene Chr9:43526796-43541799 (+)
WSB/EiJ MGP_WSBEiJ_G0033849
protein coding gene Chr9:43264750-43280096 (+)



Homology
more
  • Human Ortholog
    SCN2B, sodium voltage-gated channel beta subunit 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SCN2B, sodium voltage-gated channel beta subunit 2
  • Synonyms
    ATFB14
  • Links
    NCBI Gene ID: 6327
    neXtProt AC: NX_O60939
    UniProt: O60939

  • Chr Location
    11q23.3; chr11:118162806-118176639 (-)  GRCh38

Human Diseases
more
  • Diseases
    1 with human SCN2B associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 3 alleles in 3 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display decreased sodium channel density, altered voltage dependence of inactivation, and increased susceptibility to pilocarpine-induced seizures but appear normal in other neurological tests. Impaired glucose tolerance in homozygous mutant males is seen.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 72821 NCBI Gene Model | MGI Sequence Detail 12195 C57BL/6J ±  kb
    transcript NM_001014761 RefSeq | MGI Sequence Detail 4562 ZRU/MplStud  
    polypeptide Q56A07 UniProt | EBI | MGI Sequence Detail 215 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 9

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-35382, MGI:1920071, MGI:2143131, MGI:2685029
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 17
    • Earliest
      J:45864 Isom LL, et al., Structure and function of the beta 2 subunit of brain sodium channels, a transmembrane glycoprotein with a CAM motif. Cell. 1995 Nov 3;83(3):433-42
    • Latest
      J:298554 Tan YX, et al., MicroRNA449a regulates the progression of brain aging by targeting SCN2B in SAMP8 mice. Int J Mol Med. 2020 Apr;45(4):1091-1102

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory