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Tmpo
Gene Detail
Symbol

Name
ID
Tmpo
thymopoietin
MGI:106920
Synonyms
5630400D24Rik, lamina-associated polypeptide 2, LAP2, TP
Feature Type
protein coding gene
Genetic Map
Chromosome 10
45.66 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr10:91147571-91171582 bp, - strand
From Ensembl annotation of GRCm38

  24012 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31144  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: thymopoietin I
Gene Tree: Tmpo

Human
homologs
Human Homolog TMPO, thymopoietin
NCBI Gene ID 7112
neXtProt AC  NX_P42166, NX_P42167
Human Synonyms  CMD1T, LAP2, LEMD4, PRO0868, TP
Human Chr (Location)  12q22; chr12:98515573-98550379 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human TMPO
Mutations,
alleles, and
phenotypes
All mutations/alleles(33) : Gene trapped(30) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous null for a protein isoform generated from this locus have hyperproliferation of epidermal and erythroid progenitor cells that leads to thickened paws and increased crypt lengths in the colon.
 
Interactions
Tmpo interacts with 293 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process regulation of transcription, DNA-templated
Component chromatin, chromosome, ...
Function DNA binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (289)    Tissues (174)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 144
RT-PCR 145
cDNA source data(38)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(48) Genomic(4) cDNA(39) Primer pair(5)
Microarray probesets(10)
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000019961 Ensembl Gene Model | MGI Sequence Detail 24012 C57BL/6J ±  kb
transcript ENSMUST00000020123 Ensembl | MGI Sequence Detail 3776 Not Applicable 
polypeptide ENSMUSP00000020123 Ensembl | MGI Sequence Detail 693 Not Applicable 

For the selected sequences
All sequences(114) RefSeq(15) UniProt(14)
Polymorphisms
RFLP(1) : SNPs within 2kb(82 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR021623 Lamina-associated polypeptide 2 alpha
InterPro IPR003887 LEM domain
InterPro IPR011015 LEM/LEM-like domain
InterPro IPR013146 LEM-like domain
Protein Ontology PR:000035209 lamina-associated polypeptide 2, isoforms alpha/zeta
References
(Earliest) J:33214 Berger R, et al., The characterization and localization of the mouse thymopoietin/lamina-associated polypeptide 2 gene and its alternatively spliced products. Genome Res. 1996 May;6(5):361-70
(Latest) J:200658 Pilat U, et al., The muscle dystrophy-causing DeltaK32 lamin A/C mutant does not impair the functions of the nucleoplasmic lamin-A/C-LAP2alpha complex in mice. J Cell Sci. 2013 Apr 15;126(Pt 8):1753-62
All references(58)
Other
accession IDs
MGD-MRK-35381, MGI:1918700, MGI:2143540, MGI:2143653, MGI:2143828, MGI:2143858

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory