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Tmpo Gene Detail
Summary
  • Symbol
    Tmpo
  • Name
    thymopoietin
  • Synonyms
    5630400D24Rik, lamina-associated polypeptide 2, LAP2, TP
  • Feature Type
    protein coding gene
  • IDs
    MGI:106920
    NCBI Gene: 21917
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:90983433-91017177 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 10, 45.66 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    83 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106920
protein coding gene Chr10:90983433-91017614 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017645
protein coding gene Chr10:92441132-92465142 (-)
A/J MGP_AJ_G0017624
protein coding gene Chr10:89233023-89257037 (-)
AKR/J MGP_AKRJ_G0017582
protein coding gene Chr10:91794773-91818788 (-)
BALB/cJ MGP_BALBcJ_G0017587
protein coding gene Chr10:89517975-89541982 (-)
C3H/HeJ MGP_C3HHeJ_G0017410
protein coding gene Chr10:91813320-91837361 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018044
protein coding gene Chr10:95496589-95520636 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015726
protein coding gene Chr10:84900462-84924324 (-)
CAST/EiJ MGP_CASTEiJ_G0016975
protein coding gene Chr10:91741457-91767375 (-)
CBA/J MGP_CBAJ_G0017379
protein coding gene Chr10:99452831-99480278 (-)
DBA/2J MGP_DBA2J_G0017485
protein coding gene Chr10:88356674-88380687 (-)
FVB/NJ MGP_FVBNJ_G0017477
protein coding gene Chr10:87576077-87600084 (-)
LP/J MGP_LPJ_G0017559
protein coding gene Chr10:93075346-93101123 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017508
protein coding gene Chr10:100897700-100921640 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018081
protein coding gene Chr10:91683932-91707967 (-)
PWK/PhJ MGP_PWKPhJ_G0016756
protein coding gene Chr10:88416139-88440168 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016544
protein coding gene Chr10:90438893-90462919 (-)
WSB/EiJ MGP_WSBEiJ_G0017034
protein coding gene Chr10:91655572-91679709 (-)



Homology
more
  • Human Ortholog
    TMPO, thymopoietin
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMPO, thymopoietin
  • Synonyms
    CMD1T, LAP2, LEMD4, PRO0868, TP
  • Links
    NCBI Gene ID: 7112
    neXtProt AC: NX_P42166, NX_P42167
    UniProt: P42166, P42167

  • Chr Location
    12q23.1; chr12:98515573-98550351 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous null for a protein isoform generated from this locus have hyperproliferation of epidermal and erythroid progenitor cells that leads to thickened paws and increased crypt lengths in the colon.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000019961 Ensembl Gene Model | MGI Sequence Detail 33745 C57BL/6J ±  kb
    transcript ENSMUST00000020123 Ensembl | MGI Sequence Detail 3772 Not Applicable  
    polypeptide ENSMUSP00000020123 Ensembl | MGI Sequence Detail 693 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 53
      Genomic 4
      cDNA 42
      Primer pair 6
      Other 1

      Microarray probesets 10
    Other
    Accession IDs
    less
    MGD-MRK-35381, MGI:1918700, MGI:2143540, MGI:2143653, MGI:2143828, MGI:2143858
    References
    more
    • Summaries
      All 71
      Developmental Gene Expression 18
      Gene Ontology 9
      Phenotypes 19
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:322547 Sidorenko E, et al., Lamina-associated polypeptide 2alpha is required for intranuclear MRTF-A activity. Sci Rep. 2022 Feb 10;12(1):2306

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory