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Tmpo Gene Detail
Summary
  • Symbol
    Tmpo
  • Name
    thymopoietin
  • Synonyms
    5630400D24Rik, lamina-associated polypeptide 2, LAP2, TP
  • Feature Type
    protein coding gene
  • IDs
    MGI:106920
    NCBI Gene: 21917
  • Gene Overview
    MyGene.info: TMPO
Location & Maps
more
  • Sequence Map
    Chr10:91147571-91171582 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      24012 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 45.66 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    TMPO, thymopoietin
  • Vertebrate Orthologs
    11
  • Human Ortholog
    TMPO, thymopoietin
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CMD1T, LAP2, LEMD4, PRO0868, TP
  • Links
    NCBI Gene ID: 7112
    neXtProt AC: NX_P42166, NX_P42167

  • Chr Location
    12q22; chr12:98515573-98550379 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human TMPO associations

Human Disease Mouse Models
       Cardiomyopathy, Dilated, 1t; CMD1T   OMIM: 613740
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    35
  • Chemically induced (other)
    1
  • Gene trapped
    30
  • Targeted
    3
  • Transposon induced
    1
  • Genomic Mutations
    2 involving Tmpo
  • Incidental Mutations
Mice homozygous null for a protein isoform generated from this locus have hyperproliferation of epidermal and erythroid progenitor cells that leads to thickened paws and increased crypt lengths in the colon.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000019961 Ensembl Gene Model | MGI Sequence Detail 24012 C57BL/6J ±  kb
transcript ENSMUST00000020123 Ensembl | MGI Sequence Detail 3776 Not Applicable  
polypeptide ENSMUSP00000020123 Ensembl | MGI Sequence Detail 693 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    83 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 49
    Genomic 4
    cDNA 40
    Primer pair 5

    Microarray probesets 10
Other
Accession IDs
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MGD-MRK-35381, MGI:1918700, MGI:2143540, MGI:2143653, MGI:2143828, MGI:2143858
References
more
  • Summaries
    All 52
    Developmental Gene Expression 13
    Gene Ontology 7
    Phenotypes 16
  • Earliest
    J:33214 Berger R, et al., The characterization and localization of the mouse thymopoietin/lamina-associated polypeptide 2 gene and its alternatively spliced products. Genome Res. 1996 May;6(5):361-70
  • Latest
    J:200658 Pilat U, et al., The muscle dystrophy-causing DeltaK32 lamin A/C mutant does not impair the functions of the nucleoplasmic lamin-A/C-LAP2alpha complex in mice. J Cell Sci. 2013 Apr 15;126(Pt 8):1753-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory