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Msra Gene Detail
Summary
  • Symbol
    Msra
  • Name
    methionine sulfoxide reductase A
  • Synonyms
    2310045J23Rik, 6530413P12Rik, MSR-A
  • Feature Type
    protein coding gene
  • IDs
    MGI:106916
    NCBI Gene: 110265
  • Gene Overview
    MyGene.info: MSRA
Location & Maps
more
  • Sequence Map
    Chr14:64122623-64455903 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      333281 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 33.36 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    MSRA, methionine sulfoxide reductase A
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MSRA, methionine sulfoxide reductase A
    Orthology source: HomoloGene
  • Synonyms
    PMSR
  • Links
    NCBI Gene ID: 4482
    neXtProt AC: NX_Q9UJ68

  • Chr Location
    8p23.1; chr8:10054224-10428891 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 5812
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: MSRA
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    44
  • Chemically induced (other)
    1
  • Gene trapped
    38
  • Targeted
    4
  • Transgenic
    1
  • Genomic Mutations
    1 involving Msra
  • Incidental Mutations
Mice homozygous for disruptions in this allele display an increased sensitivity to oxidative stress, reductions in related enzyme levels, and reduced life spans.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000054733 Ensembl Gene Model | MGI Sequence Detail 333281 C57BL/6J ±  kb
transcript ENSMUST00000067927 Ensembl | MGI Sequence Detail 1862 Not Applicable  
polypeptide ENSMUSP00000065754 Ensembl | MGI Sequence Detail 233 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1558 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000010680 peptide methionine sulfoxide reductase
  • PDB
  • EC
  • InterPro Domains
    IPR028427 Peptide methionine sulfoxide reductase
    IPR002569 Peptide methionine sulphoxide reductase MsrA
Molecular
Reagents
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  • All nucleic 58
    cDNA 57
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-35377, MGI:1914949, MGI:1923458
References
more
  • Summaries
    All 59
    Developmental Gene Expression 3
    Gene Ontology 7
    Phenotypes 29
  • Earliest
    J:33347 Moskovitz J, et al., Chromosomal localization of the mammalian peptide-methionine sulfoxide reductase gene and its differential expression in various tissues. Proc Natl Acad Sci U S A. 1996 Apr 16;93(8):3205-8
  • Latest
    J:206322 Kwon TJ, et al., Methionine sulfoxide reductase B3 deficiency causes hearing loss due to stereocilia degeneration and apoptotic cell death in cochlear hair cells. Hum Mol Genet. 2014 Mar 15;23(6):1591-601

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory