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Msra
Gene Detail
Symbol

Name
ID
Msra
methionine sulfoxide reductase A
MGI:106916
Synonyms
2310045J23Rik, 6530413P12Rik, MSR-A
Feature Type
protein coding gene
Genetic Map
Chromosome 14
33.36 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr14:64122623-64455903 bp, - strand
From Ensembl annotation of GRCm38

  333281 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5812  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MSRA
Gene Tree: Msra

Human
homologs
MSRA, methionine sulfoxide reductase A
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 4482
neXtProt AC: NX_Q9UJ68

Human Synonyms: PMSR

Human Chr (Location): 8p23.1; chr8:10054224-10428891 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(42) : Gene trapped(38) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for disruptions in this allele display an increased sensitivity to oxidative stress, reductions in related enzyme levels, and reduced life spans.
 
Interactions
Msra interacts with 70 markers (Mir7-2, Mir7b, Mir10b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (3 records)
Data Summary: Results (94)    Tissues (94)    Images (7)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
cDNA source data(57)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase msra.1, msra.2    NEW 
Molecular
reagents
All nucleic(58) cDNA(57) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000054733 (Evidence)
Entrez Gene 110265 (Evidence)
UniGene 26713
DFCI TC1578897, TC1593679, TC1684013, TC1639961, TC1596670
DoTS DT.91336972, DT.528500, DT.101704620, DT.101400048, DT.101196823
NIA Mouse Gene Index U035680
EC 1.8.4.11
PDB 2L90
Consensus CDS Project CCDS27209.1
International Mouse Phenotyping Consortium Status Msra
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000054733 Ensembl Gene Model | MGI Sequence Detail 333281 C57BL/6J ±  kb
transcript ENSMUST00000067927 Ensembl | MGI Sequence Detail 1862 Not Applicable 
polypeptide ENSMUSP00000065754 Ensembl | MGI Sequence Detail 233 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(20) UniProt(1)
Polymorphisms
RFLP(2) : SNPs within 2kb(1590 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1592)
Protein-related
information
ResourceIDDescription
InterPro IPR002569 Peptide methionine sulphoxide reductase MsrA
Protein Ontology PR:000010680 peptide methionine sulfoxide reductase
References
(Earliest) J:33347 Moskovitz J, et al., Chromosomal localization of the mammalian peptide-methionine sulfoxide reductase gene and its differential expression in various tissues. Proc Natl Acad Sci U S A. 1996 Apr 16;93(8):3205-8
(Latest) J:206322 Kwon TJ, et al., Methionine sulfoxide reductase B3 deficiency causes hearing loss due to stereocilia degeneration and apoptotic cell death in cochlear hair cells. Hum Mol Genet. 2014 Mar 15;23(6):1591-601
All references(62)
Other
accession IDs
MGD-MRK-35377, MGI:1914949, MGI:1923458

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory