Hccs
Gene Detail

Symbol Name ID

Hccs holocytochrome c synthetase MGI:106911

Feature Type

protein coding gene

Genetic Map

Chromosome X

78.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

ChrX:169250193-169320372 bp, - strand From VEGA annotation of GRCm38   70180 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3897  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Hccs

Human homologs

Human Homolog		HCCS, holocytochrome c synthase
NCBI Gene ID		3052
neXtProt AC		NX_P53701
Human Synonyms		CCHL, MCOPS7
Human Chr (Location)		Xp22.3; chrX:11129406-11141206 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human HCCS

Alleles and phenotypes

All alleles(5) : Targeted(2) Gene trapped(3)
 

Homozygous female or hemizygous males for a conditional allele activated in the heart exhibit fetal lethality associated with abnormal fetal cardiomyocyte morphology and physiology.

 
Human Diseases Modeled Using Mouse Hccs (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (8 annotations)

Component	membrane, mitochondrial inner membrane, ...
Function	holocytochrome-c synthase activity, lyase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (46)    Tissues (45)    Images (1)
Theiler Stages: 23, 28

Assay Type	Results
RT-PCR	46

cDNA source data(33)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(36) Genomic(2) cDNA(33) Primer pair(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000019596 (Evidence)
Ensembl Gene Model	ENSMUSG00000031352 (Evidence)
Entrez Gene	15159 (Evidence)
UniGene	284033
NIA Mouse Gene Index	U039886
EC	4.4.1.17
Consensus CDS Project	CCDS30535.1
International Mouse Knockout Project Status	Hccs

Sequences

Length	Strain/Species
genomic	OTTMUSG00000019596	VEGA Gene Model | MGI Sequence Detail	70180	C57BL/6J
transcript	OTTMUST00000046815	VEGA | MGI Sequence Detail	2320	Not Applicable
polypeptide	OTTMUSP00000021174	VEGA | MGI Sequence Detail	272	Not Applicable

All sequences(30) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(2 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000511	Cytochrome c/c1 haem-lyase
Protein Ontology	PR:000008469	cytochrome c-type heme lyase

References

(Earliest) J:38101 Limbach KJ, et al., Characterization of a mouse somatic cytochrome c gene and three cytochrome c pseudogenes. Nucleic Acids Res. 1985 Jan 25;13(2):617-30
(Latest) J:151002 Pagliarini DJ, et al., A mitochondrial protein compendium elucidates complex I disease biology. Cell. 2008 Jul 11;134(1):112-23
All references(34)

Other accession IDs

MGD-MRK-35372