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Hccs
Gene Detail
Symbol

Name
ID
Hccs
holocytochrome c synthetase
MGI:106911
Feature Type
protein coding gene
Genetic Map
Chromosome X
78.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
ChrX:169250193-169320372 bp, - strand
From VEGA annotation of GRCm38

  70180 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3897  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: HCCS
Gene Tree: Hccs

Human
homologs
HCCS, holocytochrome c synthase
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3052
neXtProt AC: NX_P53701

Human Synonyms: CCHL, LSDMCA1, MCOPS7, MLS

Human Chr (Location): Xp22.3; chrX:11111286-11123086 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human HCCS

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(3) Targeted(2)
 
Homozygous female or hemizygous males for a conditional allele activated in the heart exhibit fetal lethality associated with abnormal fetal cardiomyocyte morphology and physiology.
 
Human Diseases Modeled in Mice Using Hccs (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Hccs interacts with 290 markers (Mir1b, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Component membrane, mitochondrial inner membrane, ...
Function holocytochrome-c synthase activity, lyase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (46)    Tissues (45)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 46
cDNA source data(33)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase hccs    NEW 
Molecular
reagents
All nucleic(36) Genomic(2) cDNA(33) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000019596 (Evidence)
Ensembl Gene Model ENSMUSG00000031352 (Evidence)
Entrez Gene 15159 (Evidence)
UniGene 284033
NIA Mouse Gene Index U039886
EC 4.4.1.17
Consensus CDS Project CCDS30535.1
International Mouse Phenotyping Consortium Status Hccs
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019596 VEGA Gene Model | MGI Sequence Detail 70180 C57BL/6J ±  kb
transcript OTTMUST00000046815 VEGA | MGI Sequence Detail 2320 Not Applicable 
polypeptide OTTMUSP00000021174 VEGA | MGI Sequence Detail 272 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(8) UniProt(3)
Polymorphisms
SNPs within 2kb(181 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000511 Cytochrome c/c1 haem-lyase
Protein Ontology PR:000008469 cytochrome c-type heme lyase
References
(Earliest) J:38101 Limbach KJ, et al., Characterization of a mouse somatic cytochrome c gene and three cytochrome c pseudogenes. Nucleic Acids Res. 1985 Jan 25;13(2):617-30
(Latest) J:206774 Wolstenholme JT, et al., Sexual differentiation in the developing mouse brain: contributions of sex chromosome genes. Genes Brain Behav. 2013 Mar;12(2):166-80
All references(34)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-35372

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory