About   Help   FAQ
Hccs
Gene Detail
 Symbol
Name
ID
Hccs
holocytochrome c synthetase
MGI:106911
Feature Type protein coding gene
Genetic Map
Chromosome X
78.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
ChrX:169250193-169320372 bp, - strand
From VEGA annotation of GRCm38

  70180 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3897  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Hccs

Human
homologs
Human Homolog HCCS, holocytochrome c synthase
NCBI Gene ID 3052
neXtProt AC  NX_P53701
Human Synonyms  CCHL, MCOPS7, MLS
Human Chr (Location)  Xp22.3; chrX:11111286-11123086 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human HCCS
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(3) Targeted(2)
 
Homozygous female or hemizygous males for a conditional allele activated in the heart exhibit fetal lethality associated with abnormal fetal cardiomyocyte morphology and physiology.
 
Human Diseases Modeled Using Mouse Hccs (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Hccs interacts with 291 markers (Mir1b, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Component membrane, mitochondrial inner membrane, ...
Function holocytochrome-c synthase activity, lyase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (46)    Tissues (45)    Images (1)
Theiler Stages: 23, 28
Assay TypeResults
RT-PCR 46
cDNA source data(33)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(36) Genomic(2) cDNA(33) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000019596 (Evidence)
Ensembl Gene ModelENSMUSG00000031352 (Evidence)
Entrez Gene15159 (Evidence)
UniGene284033
NIA Mouse Gene IndexU039886
EC4.4.1.17
Consensus CDS ProjectCCDS30535.1
International Mouse Knockout Project StatusHccs
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019596 VEGA Gene Model | MGI Sequence Detail 70180 C57BL/6J ±  kb
transcript OTTMUST00000046815 VEGA | MGI Sequence Detail 2320 Not Applicable 
polypeptide OTTMUSP00000021174 VEGA | MGI Sequence Detail 272 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(8) UniProt(3)
Polymorphisms SNPs within 2kb(181 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000511 Cytochrome c/c1 haem-lyase
Protein Ontology PR:000008469 cytochrome c-type heme lyase
References (Earliest) J:38101 Limbach KJ, et al., Characterization of a mouse somatic cytochrome c gene and three cytochrome c pseudogenes. Nucleic Acids Res. 1985 Jan 25;13(2):617-30
(Latest) J:206774 Wolstenholme JT, et al., Sexual differentiation in the developing mouse brain: contributions of sex chromosome genes. Genes Brain Behav. 2013 Mar;12(2):166-80
All references(35)
Other
accession IDs
MGD-MRK-35372

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/09/2014
MGI 5.19
The Jackson Laboratory