Srpk1 MGI Mouse Gene Detail - MGI:106908 - serine/arginine-rich protein specific kinase 1

Symbol

Srpk1
Name

serine/arginine-rich protein specific kinase 1
Synonyms

SR protein-specific kinase 1

Feature Type

protein coding gene
IDs

MGI:106908
NCBI Gene: 20815
Alliance

genome feature page
Transcription Start Sites

5 TSS

Sequence Map

Chr17:28806622-28841683 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 14.78 cM
Mapping Data

4 experiments

SNPs within 2kb

136 from dbSNP Build 142
Strain Annotations

27
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_106908	protein coding gene	Chr17:28806622-28841795 (-)
129S1/SvImJ	ENSMUSG00200051114	protein coding gene	Chr17:24478000-24499800 (-)
129S1/SvImJ	ENSMUSGG00200054998	protein coding gene	Chr17:24476931-24477752 (-)
A/J	ENSMUSGG00195055538	protein coding gene	Chr17:25293274-25294095 (-)
A/J	ENSMUSG00195053037	protein coding gene	Chr17:25294343-25316134 (-)
AKR/J	ENSMUSGG00220054947	protein coding gene	Chr17:24340917-24341738 (-)
AKR/J	ENSMUSG00220047048	protein coding gene	Chr17:24341986-24363775 (-)
BALB/cJ	ENSMUSG00180036914	protein coding gene	Chr17:24780482-24802281 (-)
BALB/cJ	ENSMUSGG00180055613	protein coding gene	Chr17:24779413-24780234 (-)
C3H/HeJ	ENSMUSG00175053397	protein coding gene	Chr17:24330407-24352194 (-)
C3H/HeJ	ENSMUSGG00175055225	protein coding gene	Chr17:24329338-24330159 (-)
C57BL/6NJ	ENSMUSG00215053764	protein coding gene	Chr17:24330449-24352234 (-)
C57BL/6NJ	ENSMUSGG00215055854	protein coding gene	Chr17:24329380-24330201 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021326	protein coding gene	Chr17:24444014-24481741 (-)
CAST/EiJ	no annotation
CBA/J	ENSMUSGG00210055144	protein coding gene	Chr17:24167778-24168599 (-)
CBA/J	ENSMUSG00210044936	protein coding gene	Chr17:24168847-24190633 (-)
DBA/2J	ENSMUSGG00185057970	protein coding gene	Chr17:26383065-26383886 (-)
DBA/2J	ENSMUSG00185038961	protein coding gene	Chr17:26384134-26405926 (-)
FVB/NJ	ENSMUSG00205048051	protein coding gene	Chr17:24645386-24667175 (-)
FVB/NJ	ENSMUSGG00205054685	protein coding gene	Chr17:24644317-24645138 (-)
JF1/MsJ	no annotation
LP/J	ENSMUSG00230054514	protein coding gene	Chr17:27903802-27925596 (-)
LP/J	ENSMUSGG00230055903	protein coding gene	Chr17:27902733-27903554 (-)
NOD/ShiLtJ	ENSMUSGG00190055151	protein coding gene	Chr17:24277227-24278048 (-)
NOD/ShiLtJ	ENSMUSG00190051203	protein coding gene	Chr17:24278296-24300065 (-)
NZO/HlLtJ	ENSMUSGG00225055733	protein coding gene	Chr17:29870642-29871463 (-)
NZO/HlLtJ	ENSMUSG00225051214	protein coding gene	Chr17:29871711-29893496 (-)
PWK/PhJ	no annotation
SPRET/EiJ	ENSMSPG00010042981	protein coding gene	Chr17:25052026-25086019 (-)
WSB/EiJ	no annotation

Human Ortholog

SRPK1, SRSF protein kinase 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SRPK1, SRSF protein kinase 1
Synonyms

SFRSK1
Links

HGNC:11305

NCBI Gene ID: 6732

UniProt: Q96SB4
Chr Location

6p21.31; chr6:35832966-35921342 (-) GRCh38

MGI Vertebrate Homology

Srpk1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: SRPK1
Gene Tree

Srpk1

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Phenotype Summary

3 phenotypes from 2 alleles in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

56
Endonuclease-mediated

4
Gene trapped

50
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

48 strains or lines available

Mice homozygous for a null allele show lethality before E14.5.

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All GO Annotations

66
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

692
Tissues

95
cDNA Data

21
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase srpk1

ZFIN srpk1a

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All Sequences

88
RefSeq

7
UniProt

12
CCDS

CCDS37531.1

Ensembl

ENSMUSG00000004865 (Evidence)
NCBI Gene

20815

			Length	Strain/Species	Flank
genomic	ENSMUSG00000004865	Ensembl Gene Model \| MGI Sequence Detail	35062	C57BL/6J	± kb
transcript	ENSMUST00000130643	Ensembl \| MGI Sequence Detail	4653	Not Applicable
polypeptide	ENSMUSP00000116259	Ensembl \| MGI Sequence Detail	648	Not Applicable

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UniProt

12 Sequences
Protein Ontology

PR:000015629 SRSF protein kinase 1

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site
GlyGen

O70551 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 23

cDNA 22

Primer pair 1

Microarray probesets 6

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MGD-MRK-35369, MGI:2146973

Summaries

All 57

Developmental Gene Expression 4

Gene Ontology 12

Phenotypes 11
Earliest

J:33905 Gul JF, et al., A serine kinase regulates intracellular localization of splicing factors in the cell cycle. Nature. 1994;369(6482):678-682
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Srpk1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr147146	Chr17:28841453-28841476 (-)	218 bp
Tssr147145	Chr17:28841393-28841447 (-)	263 bp
Tssr147144	Chr17:28841059-28841076 (-)	615 bp
Tssr147143	Chr17:28841040-28841055 (-)	635 bp
Tssr147142	Chr17:28822533-28822535 (-)	19,149 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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