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Srpk1 Gene Detail
Summary
  • Symbol
    Srpk1
  • Name
    serine/arginine-rich protein specific kinase 1
  • Synonyms
    SR protein-specific kinase 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:106908
    NCBI Gene: 20815
  • Gene Overview
    MyGene.info: SRPK1
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:28589590-28622647 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 14.78 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    131 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106908
protein coding gene Chr17:28587648-28622647 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023446
protein coding gene Chr17:28020036-28059435 (-)
A/J MGP_AJ_G0023404
protein coding gene Chr17:27073094-27111613 (-)
AKR/J MGP_AKRJ_G0023369
protein coding gene Chr17:27286901-27325493 (-)
BALB/cJ MGP_BALBcJ_G0023409
protein coding gene Chr17:27357839-27393219 (-)
C3H/HeJ MGP_C3HHeJ_G0023170
protein coding gene Chr17:27685668-27724168 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023851
protein coding gene Chr17:29144789-29185316 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021326
protein coding gene Chr17:24444014-24481741 (-)
CAST/EiJ MGP_CASTEiJ_G0022671
protein coding gene Chr17:27654284-27688080 (-)
CBA/J MGP_CBAJ_G0023144
protein coding gene Chr17:30196220-30255849 (-)
DBA/2J MGP_DBA2J_G0023275
protein coding gene Chr17:26633505-26670857 (-)
FVB/NJ MGP_FVBNJ_G0023245
protein coding gene Chr17:26456830-26493578 (-)
LP/J MGP_LPJ_G0023353
protein coding gene Chr17:28270352-28308967 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023263
protein coding gene Chr17:29598382-29646868 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023893
protein coding gene Chr17:27727768-27768872 (-)
PWK/PhJ MGP_PWKPhJ_G0022421
protein coding gene Chr17:25451873-25488075 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022239
protein coding gene Chr17:25714711-25750949 (-)
WSB/EiJ MGP_WSBEiJ_G0022733
protein coding gene Chr17:27715065-27754135 (-)



Homology
more
  • Human Ortholog
    SRPK1, SRSF protein kinase 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    SRPK1, SRSF protein kinase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SFRSK1
  • Links
    NCBI Gene ID: 6732
    neXtProt AC: NX_Q96SB4
    UniProt: Q96SB4

  • Chr Location
    6p21.31; chr6:35833034-35921180 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 20815 NCBI Gene Model | MGI Sequence Detail 33058 C57BL/6J ±  kb
transcript NM_016795 RefSeq | MGI Sequence Detail 2540 C57BL/6  
polypeptide O70551 UniProt | EBI | MGI Sequence Detail 648 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    8 Sequences
  • EC
  • InterPro Domains
    IPR017441 Protein kinase, ATP binding site
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain superfamily
    IPR008271 Serine/threonine-protein kinase, active site
Molecular
Reagents
less
  • All nucleic 23
    cDNA 22
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-35369, MGI:2146973
References
more
  • Summaries
    All 42
    Developmental Gene Expression 4
    Gene Ontology 7
    Phenotypes 8
  • Earliest
    J:33905 Gul JF, et al., A serine kinase regulates intracellular localization of splicing factors in the cell cycle. Nature. 1994;369(6482):678-682
  • Latest
    J:262291 Lin JC, Multi-posttranscriptional regulations lessen the repressive effect of SRPK1 on brown adipogenesis. Biochim Biophys Acta. 2018 May;1863(5):503-514

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory