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Srpk1
Gene Detail
Symbol

Name
ID
Srpk1
serine/arginine-rich protein specific kinase 1
MGI:106908
Synonyms
SR protein-specific kinase 1
Feature Type
protein coding gene
Genetic Map
Chromosome 17
14.78 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr17:28587648-28622521 bp, - strand
From VEGA annotation of GRCm38

  34874 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:110962  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: SRPK1
Protein SuperFamily: serine/threonine-protein kinase
Gene Tree: Srpk1

Human
homologs
SRPK1, SRSF protein kinase 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 6732
neXtProt AC: NX_Q96SB4

Human Synonyms: SFRSK1

Human Chr (Location): 6p21.31; chr6:35833034-35921180 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(64) : Gene trapped(62) Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Srpk1 interacts with 326 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process cell differentiation, chromosome segregation, ...
Component cytoplasm, endoplasmic reticulum, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (95)    Tissues (95)    Images (16)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 95
cDNA source data(19)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase srpk1 ; ZFIN srpk1a    NEW 
Molecular
reagents
All nucleic(21) cDNA(20) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000024247 (Evidence)
Ensembl Gene Model ENSMUSG00000004865 (Evidence)
Entrez Gene 20815 (Evidence)
DFCI TC1682268, TC1607410, TC1575142, TC1756936
DoTS DT.101718684, DT.101403424, DT.40149061, DT.487812, DT.94274873
NIA Mouse Gene Index U037611
EC 2.7.11.1
Consensus CDS Project CCDS37531.1
International Mouse Phenotyping Consortium Status Srpk1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024247 VEGA Gene Model | MGI Sequence Detail 34874 C57BL/6J ±  kb
transcript OTTMUST00000059342 VEGA | MGI Sequence Detail 4465 Not Applicable 
polypeptide OTTMUSP00000028859 VEGA | MGI Sequence Detail 648 Not Applicable 

For the selected sequences
All sequences(72) RefSeq(12) UniProt(8)
Polymorphisms
RFLP(1) : SNPs within 2kb(136 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000015629 SRSF protein kinase 1
References
(Earliest) J:33905 Gul JF, et al., A serine kinase regulates intracellular localization of splicing factors in the cell cycle. Nature. 1994;369(6482):678-682
(Latest) J:213142 Wang P, et al., Both decreased and increased SRPK1 levels promote cancer by interfering with PHLPP-mediated dephosphorylation of Akt. Mol Cell. 2014 May 8;54(3):378-91
All references(42)
Other
accession IDs
MGD-MRK-35369, MGI:2146973

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory