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Tead4
Gene Detail
 Symbol
Name
ID
Tead4
TEA domain family member 4
MGI:106907
Synonyms Etfr2, ETFR-2a, Rtef1, Tcf13r1, TEAD-4, Tef3, TEF-3, Tefr, Tefr1a
Feature Type protein coding gene
Genetic Map
Chromosome 6
62.92 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr6:128224288-128300823 bp, - strand
From VEGA annotation of GRCm38

  76536 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:74463  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: transcriptional enhancer factor
Gene Tree: Tead4

Human
homologs
Human Homolog TEAD4, TEA domain family member 4
NCBI Gene ID 7004
neXtProt AC  NX_Q15561
Human Synonyms  EFTR-2, hRTEF-1B, RTEF1, TCF13L1, TEF3, TEF-3, TEFR-1
Human Chr (Location)  12p13.3-p13.2; chr12:2959312-3040676 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(101) : Gene trapped(96) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele die prior to somitogenesis, lack trophoblast stem cells and develop abnormally.
 
Interactions
Tead4 interacts with 190 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process blastocyst formation, cell fate specification, ...
Component intracellular, nucleus, ...
Function DNA binding, sequence-specific DNA binding transcription factor activity
External Resources: FuncBase
Expression
Literature Summary: (23 records)
Data Summary: Results (215)    Tissues (167)    Images (18)
Theiler Stages: 1, 2, 3, 4, 5, 12, 15, 16, 17, 21, 22, 23, 26, 28
Assay TypeResults
Immunohistochemistry 4
RNA in situ 178
Northern blot 14
RT-PCR 19
cDNA source data(41)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(46) cDNA(41) Primer pair(3) Other(2)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000022461 (Evidence)
Ensembl Gene ModelENSMUSG00000030353 (Evidence)
Entrez Gene21679 (Evidence)
UniGene14774
DFCITC1598968, TC1688807
DoTSDT.102542083, DT.531133, DT.55226999, DT.87050428
NIA Mouse Gene IndexU041049
PDB3JUA, 4EAZ, 4LN0
Consensus CDS ProjectCCDS39645.1, CCDS39646.1
International Mouse Knockout Project StatusTead4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022461 VEGA Gene Model | MGI Sequence Detail 76536 C57BL/6J ±  kb
transcript OTTMUST00000053720 VEGA | MGI Sequence Detail 3076 Not Applicable 
polypeptide OTTMUSP00000025555 VEGA | MGI Sequence Detail 427 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(4) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(565 from dbSNP Build 137)    SNPs within 2kb including multiple locations(571)
Protein-related
information
ResourceIDDescription
InterPro IPR000818 TEA/ATTS
InterPro IPR016361 Transcriptional enhancer factor
InterPro IPR027255 Transcriptional enhancer factor TEF-3 (TEAD4)
Protein Ontology PR:000016221 transcriptional enhancer factor TEF-3
References (Earliest) J:48110 Burglin TR, The TEA domain: a novel, highly conserved DNA-binding motif [letter]. Cell. 1991 Jul 12;66(1):11-2
(Latest) J:201607 Wu G, et al., Establishment of totipotency does not depend on Oct4A. Nat Cell Biol. 2013 Sep;15(9):1089-97
All references(67)
Other
accession IDs
MGD-MRK-35368

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory