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Tead4 Gene Detail
Summary
  • Symbol
    Tead4
  • Name
    TEA domain family member 4
  • Synonyms
    Etfr2, ETFR-2a, Rtef1, Tcf13r1, TEAD-4, Tef3, TEF-3, Tefr, Tefr1a
  • Feature Type
    protein coding gene
  • IDs
    MGI:106907
    NCBI Gene: 21679
  • Alliance
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:128204106-128277776 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 6, 62.92 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    546 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106907
protein coding gene Chr6:128201251-128277786 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031319
protein coding gene Chr6:131823457-131900009 (-)
A/J MGP_AJ_G0031290
protein coding gene Chr6:126770740-126844908 (-)
AKR/J MGP_AKRJ_G0031218
protein coding gene Chr6:130184951-130258591 (-)
BALB/cJ MGP_BALBcJ_G0031297
protein coding gene Chr6:126339664-126412410 (-)
C3H/HeJ MGP_C3HHeJ_G0031021
protein coding gene Chr6:130321731-130397515 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031756
protein coding gene Chr6:135251286-135331970 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028902
protein coding gene Chr6:123972862-124046091 (-)
CAST/EiJ MGP_CASTEiJ_G0030403
protein coding gene Chr6:130604223-130681185 (-)
CBA/J MGP_CBAJ_G0030982
protein coding gene Chr6:140467284-140542757 (-)
DBA/2J MGP_DBA2J_G0031138
protein coding gene Chr6:125663615-125736240 (-)
FVB/NJ MGP_FVBNJ_G0031088
protein coding gene Chr6:124586342-124659771 (-)
LP/J MGP_LPJ_G0031218
protein coding gene Chr6:131945055-132019136 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031126
protein coding gene Chr6:144315644-144393566 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031789
protein coding gene Chr6:130189450-130267960 (-)
PWK/PhJ MGP_PWKPhJ_G0030118
protein coding gene Chr6:123959404-124038384 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029946
protein coding gene Chr6:128295642-128378929 (-)
WSB/EiJ MGP_WSBEiJ_G0030487
protein coding gene Chr6:130570774-130658942 (-)



Homology
more
  • Human Ortholog
    TEAD4, TEA domain transcription factor 4
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TEAD4, TEA domain transcription factor 4
  • Synonyms
    EFTR-2, hRTEF-1B, RTEF1, TCF13L1, TEF3, TEF-3, TEFR-1
  • Links
    NCBI Gene ID: 7004
    neXtProt AC: NX_Q15561
    UniProt: Q15561

  • Chr Location
    12p13.33; chr12:2959330-3040676 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 3 alleles in 4 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele die prior to somitogenesis, lack trophoblast stem cells and develop abnormally.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21679 NCBI Gene Model | MGI Sequence Detail 73671 C57BL/6J ±  kb
    transcript NM_011567 RefSeq | MGI Sequence Detail 3076 Not Specified  
    polypeptide Q62296 UniProt | EBI | MGI Sequence Detail 427 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 61
      cDNA 46
      Primer pair 12
      Other 3

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-35368
    References
    more
    • Summaries
      All 92
      Developmental Gene Expression 35
      Gene Ontology 12
      Phenotypes 19
    • Earliest
      J:48110 Burglin TR, The TEA domain: a novel, highly conserved DNA-binding motif [letter]. Cell. 1991 Jul 12;66(1):11-2
    • Latest
      J:338268 Dos Santos M, et al., Opposing gene regulatory programs governing myofiber development and maturation revealed at single nucleus resolution. Nat Commun. 2023 Jul 19;14(1):4333

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory