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Tead4
Gene Detail
Symbol

Name
ID
Tead4
TEA domain family member 4
MGI:106907
Synonyms
Etfr2, ETFR-2a, Rtef1, Tcf13r1, TEAD-4, Tef3, TEF-3, Tefr, Tefr1a
Feature Type
protein coding gene
Genetic Map
Chromosome 6
62.92 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr6:128224288-128300823 bp, - strand
From VEGA annotation of GRCm38

  76536 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:74463  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: TEAD4
Protein SuperFamily: transcriptional enhancer factor
Gene Tree: Tead4

Human
homologs
TEAD4, TEA domain family member 4
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 7004
neXtProt AC: NX_Q15561

Human Synonyms: EFTR-2, hRTEF-1B, RTEF1, TCF13L1, TEF3, TEF-3, TEFR-1

Human Chr (Location): 12p13.3-p13.2; chr12:2959312-3040676 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(101) : Gene trapped(96) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele die prior to somitogenesis, lack trophoblast stem cells and develop abnormally.
 
Interactions
Tead4 interacts with 190 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process blastocyst formation, cell fate commitment, ...
Component cytoplasm, nucleoplasm, ...
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (23 records)
Data Summary: Results (227)    Tissues (180)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
RNA in situ 190
Northern blot 14
RT-PCR 19
cDNA source data(41)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase tead4    NEW 
Molecular
reagents
All nucleic(47) cDNA(42) Primer pair(3) Other(2)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000022461 (Evidence)
Ensembl Gene Model ENSMUSG00000030353 (Evidence)
Entrez Gene 21679 (Evidence)
UniGene 14774
DFCI TC1688807, TC1598968
DoTS DT.87050428, DT.531133, DT.55226999, DT.102542083
NIA Mouse Gene Index U041049
PDB 4EAZ, 3JUA, 4LN0
Consensus CDS Project CCDS39645.1, CCDS39646.1
International Mouse Phenotyping Consortium Status Tead4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022461 VEGA Gene Model | MGI Sequence Detail 76536 C57BL/6J ±  kb
transcript OTTMUST00000053720 VEGA | MGI Sequence Detail 3076 Not Applicable 
polypeptide OTTMUSP00000025555 VEGA | MGI Sequence Detail 427 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(4) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(565 from dbSNP Build 137)    SNPs within 2kb including multiple locations(571)
Protein-related
information
ResourceIDDescription
InterPro IPR000818 TEA/ATTS
InterPro IPR016361 Transcriptional enhancer factor
InterPro IPR027255 Transcriptional enhancer factor TEF-3 (TEAD4)
Protein Ontology PR:000016221 transcriptional enhancer factor TEF-3
References
(Earliest) J:48110 Burglin TR, The TEA domain: a novel, highly conserved DNA-binding motif [letter]. Cell. 1991 Jul 12;66(1):11-2
(Latest) J:217957 Jiao S, et al., A peptide mimicking VGLL4 function acts as a YAP antagonist therapy against gastric cancer. Cancer Cell. 2014 Feb 10;25(2):166-80
All references(70)
Other
accession IDs
MGD-MRK-35368

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory