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Selplg Gene Detail
Summary
  • Symbol
    Selplg
  • Name
    selectin, platelet (p-selectin) ligand
  • Synonyms
    CD162, Psgl1, Psgl-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:106689
    NCBI Gene: 20345
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:113818536-113832644 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 55.59 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    58 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106689
protein coding gene Chr5:113817798-113832644 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029925
protein coding gene Chr5:116502102-116516072 (-)
A/J MGP_AJ_G0029890
protein coding gene Chr5:111939313-111954228 (-)
AKR/J MGP_AKRJ_G0029828
protein coding gene Chr5:115489378-115506315 (-)
BALB/cJ MGP_BALBcJ_G0029901
protein coding gene Chr5:113309011-113322986 (-)
C3H/HeJ MGP_C3HHeJ_G0029621
protein coding gene Chr5:115976968-115991998 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030355
protein coding gene Chr5:121017394-121033362 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027583
protein coding gene Chr5:106767093-106781565 (-)
CAST/EiJ MGP_CASTEiJ_G0029029
protein coding gene Chr5:114898777-114914489 (-)
CBA/J MGP_CBAJ_G0029588
protein coding gene Chr5:125583386-125597270 (-)
DBA/2J MGP_DBA2J_G0029738
protein coding gene Chr5:112000497-112014472 (-)
FVB/NJ MGP_FVBNJ_G0029695
protein coding gene Chr5:110784712-110801905 (-)
LP/J MGP_LPJ_G0029827
protein coding gene Chr5:117071153-117085393 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029726
protein coding gene Chr5:130087770-130103408 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030396
protein coding gene Chr5:114940326-114958046 (-)
PWK/PhJ MGP_PWKPhJ_G0028743
protein coding gene Chr5:110627052-110641330 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028581
protein coding gene Chr5:112476113-112496917 (-)
WSB/EiJ MGP_WSBEiJ_G0029105
protein coding gene Chr5:115505129-115518610 (-)



Homology
more
  • Human Ortholog
    SELPLG, selectin P ligand
  • Vertebrate Orthologs
    7
  • Human Ortholog
    SELPLG, selectin P ligand
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD162, CLA, PSGL1, PSGL-1
  • Links
    NCBI Gene ID: 6404
    neXtProt AC: NX_Q14242
    UniProt: Q14242

  • Chr Location
    12q24.11; chr12:108621895-108633894 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 3 alleles in 4 genetic backgrounds
    4 phenotypes from multigenic genotypes
    71 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit neutrophillia and impaired leukocyte adhesion and rolling.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000048163 Ensembl Gene Model | MGI Sequence Detail 14109 C57BL/6J ±  kb
transcript ENSMUST00000100874 Ensembl | MGI Sequence Detail 1855 Not Applicable  
polypeptide ENSMUSP00000098436 Ensembl | MGI Sequence Detail 417 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    9 Sequences
  • PDB
  • InterPro Domains
    IPR026195 P-selectin glycoprotein ligand 1
Molecular
Reagents
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  • All nucleic 40
    Genomic 1
    cDNA 39

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-35148
References
more
  • Summaries
    All 129
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 71
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:263371 Wang Q, et al., Angiotensin II-induced Hypertension is Reduced by Deficiency of P-selectin Glycoprotein Ligand-1. Sci Rep. 2018 Feb 19;8(1):3223

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory