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Selplg
Gene Detail
Symbol

Name
ID
Selplg
selectin, platelet (p-selectin) ligand
MGI:106689
Synonyms
CD162, Psgl1, Psgl-1
Feature Type
protein coding gene
Genetic Map
Chromosome 5
55.59 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr5:113817798-113830501 bp, - strand
From Ensembl annotation of GRCm38

  12704 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2261  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: SELPLG
Gene Tree: Selplg

Human
homologs
SELPLG, selectin P ligand
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 6404
neXtProt AC: NX_Q14242

Human Synonyms: CD162, CLA, PSGL1, PSGL-1

Human Chr (Location): 12q24; chr12:108621895-108633954 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit neutrophillia and impaired leukocyte adhesion and rolling.
 
Interactions
Selplg interacts with 133 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process cell adhesion, leukocyte adhesive activation, ...
Component integral component of membrane, membrane, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (5)    Tissues (1)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 5
cDNA source data(38)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN selplg    NEW 
Molecular
reagents
All nucleic(39) Genomic(1) cDNA(38)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000048163 (Evidence)
Entrez Gene 20345 (Evidence)
UniGene 332590
DFCI TC1587911, TC1710127, TC1572763
DoTS DT.40145623, DT.110695196, DT.101408875, DT.99864705
NIA Mouse Gene Index U375907, U026593
PDB 2EMT
Consensus CDS Project CCDS51621.1
International Mouse Phenotyping Consortium Status Selplg
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000048163 Ensembl Gene Model | MGI Sequence Detail 12704 C57BL/6J ±  kb
transcript ENSMUST00000100874 Ensembl | MGI Sequence Detail 2604 Not Applicable 
polypeptide ENSMUSP00000098436 Ensembl | MGI Sequence Detail 417 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(6) UniProt(5)
Polymorphisms
RFLP(1) : SNPs within 2kb(71 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026195 P-selectin glycoprotein ligand 1
Protein Ontology PR:000001830 P-selectin glycoprotein ligand 1
References
(Earliest) J:33106 Yang J, et al., Mouse P-selectin glycoprotein ligand-1: molecular cloning, chromosomal localization, and expression of a functional P-selectin receptor. Blood. 1996 May 15;87(10):4176-86
(Latest) J:208688 Krause DS, et al., Selectins and their ligands are required for homing and engraftment of BCR-ABL1+ leukemic stem cells in the bone marrow niche. Blood. 2014 Feb 27;123(9):1361-71
All references(101)
Other
accession IDs
MGD-MRK-35148

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory