Selplg MGI Mouse Gene Detail - MGI:106689 - selectin, platelet (p-selectin) ligand

Symbol

Selplg
Name

selectin, platelet (p-selectin) ligand
Synonyms

CD162, Psgl1, Psgl-1

Feature Type

protein coding gene
IDs

MGI:106689
NCBI Gene: 20345
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

Chr5:113956597-113970705 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 55.59 cM
Mapping Data

4 experiments

SNPs within 2kb

58 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_106689	protein coding gene	Chr5:113955859-113970705 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0029925	protein coding gene	Chr5:116502102-116516072 (-)
A/J	MGP_AJ_G0029890	protein coding gene	Chr5:111939313-111954228 (-)
AKR/J	MGP_AKRJ_G0029828	protein coding gene	Chr5:115489378-115506315 (-)
BALB/cJ	MGP_BALBcJ_G0029901	protein coding gene	Chr5:113309011-113322986 (-)
C3H/HeJ	MGP_C3HHeJ_G0029621	protein coding gene	Chr5:115976968-115991998 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0030355	protein coding gene	Chr5:121017394-121033362 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027583	protein coding gene	Chr5:106767093-106781565 (-)
CAST/EiJ	MGP_CASTEiJ_G0029029	protein coding gene	Chr5:114898777-114914489 (-)
CBA/J	MGP_CBAJ_G0029588	protein coding gene	Chr5:125583386-125597270 (-)
DBA/2J	MGP_DBA2J_G0029738	protein coding gene	Chr5:112000497-112014472 (-)
FVB/NJ	MGP_FVBNJ_G0029695	protein coding gene	Chr5:110784712-110801905 (-)
LP/J	MGP_LPJ_G0029827	protein coding gene	Chr5:117071153-117085393 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029726	protein coding gene	Chr5:130087770-130103408 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030396	protein coding gene	Chr5:114940326-114958046 (-)
PWK/PhJ	MGP_PWKPhJ_G0028743	protein coding gene	Chr5:110627052-110641330 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0028581	protein coding gene	Chr5:112476113-112496917 (-)
WSB/EiJ	MGP_WSBEiJ_G0029105	protein coding gene	Chr5:115505129-115518610 (-)

Human Ortholog

SELPLG, selectin P ligand

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SELPLG, selectin P ligand
Synonyms

CD162, CLA, PSGL1, PSGL-1
Links

HGNC:10722

NCBI Gene ID: 6404

neXtProt AC: NX_Q14242

UniProt: Q14242
Chr Location

12q24.11; chr12:108621895-108633894 (-) GRCh38

MGI Vertebrate Homology

Selplg stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SELPLG
Gene Tree

Selplg

Diseases

1 with human SELPLG associations

				Human Disease	Mouse Models
				carotid artery disease IDs carotid artery disease DOID:3407 MESH:D002340 NCI:C84476 UMLS_CUI:C0007273

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

10 phenotypes from 3 alleles in 4 genetic backgrounds
4 phenotypes from multigenic genotypes
91 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

1
Endonuclease-mediated

6
Radiation induced

1
Targeted

6
Genomic Mutations

2 involving Selplg
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

49 strains or lines available

Mice homozygous for a null allele exhibit neutrophillia and impaired leukocyte adhesion and rolling.

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All GO Annotations

11
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

718
Tissues

6
cDNA Data

39
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN selplg

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All Sequences

60
RefSeq

4
UniProt

9
CCDS

CCDS51621.1

Ensembl

ENSMUSG00000048163 (Evidence)
NCBI Gene

20345

			Length	Strain/Species	Flank
genomic	ENSMUSG00000048163	Ensembl Gene Model \| MGI Sequence Detail	14109	C57BL/6J	± kb
transcript	ENSMUST00000100874	Ensembl \| MGI Sequence Detail	1855	Not Applicable
polypeptide	ENSMUSP00000098436	Ensembl \| MGI Sequence Detail	417	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000001830 P-selectin glycoprotein ligand 1

(term hierarchy)
PDB

2EMT
InterPro Domains

IPR026195 P-selectin glycoprotein ligand 1

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All nucleic 40

Genomic 1

cDNA 39

Microarray probesets 3

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MGD-MRK-35148

Summaries

All 159

Developmental Gene Expression 4

Gene Ontology 6

Phenotypes 91
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:341037 Hope JL, et al., PSGL-1 attenuates early TCR signaling to suppress CD8(+) T cell progenitor differentiation and elicit terminal CD8(+) T cell exhaustion. Cell Rep. 2023 May 30;42(5):112436

TSS for Selplg:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr52669	Chr5:113970777-113970800 (-)	-84 bp
Tssr52668	Chr5:113970664-113970724 (-)	11 bp
Tssr52667	Chr5:113970591-113970606 (-)	106 bp
Tssr52666	Chr5:113970557-113970573 (-)	140 bp
Tssr52665	Chr5:113970535-113970545 (-)	165 bp
Tssr52664	Chr5:113968630-113968636 (-)	2,072 bp
Tssr52663	Chr5:113968483-113968567 (-)	2,180 bp
Tssr52662	Chr5:113968451-113968479 (-)	2,240 bp
Tssr52661	Chr5:113963479-113963494 (-)	7,218 bp
Tssr52660	Chr5:113962388-113962399 (-)	8,311 bp
Tssr52659	Chr5:113961134-113961138 (-)	9,569 bp
Tssr52658	Chr5:113958220-113958232 (-)	12,479 bp
Tssr52657	Chr5:113958160-113958181 (-)	12,534 bp
Tssr52656	Chr5:113957362-113957386 (-)	13,331 bp
Tssr52655	Chr5:113957343-113957358 (-)	13,354 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/09/2024 MGI 6.23