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Pon2
Gene Detail
 Symbol
Name
ID
Pon2
paraoxonase 2
MGI:106687
Synonyms 6330405I24Rik
Feature Type protein coding gene
Genetic Map
Chromosome 6
1.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr6:5264147-5298455 bp, - strand
From VEGA annotation of GRCm38

  34309 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:385  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 4 zebrafish

Protein SuperFamily: paraoxonase
Gene Tree: Pon2

Human
homologs
Human Homolog PON2, paraoxonase 2
NCBI Gene ID 5445
neXtProt AC  NX_Q15165
Human Chr (Location)  7q21.3; chr7:95404862-95435072 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
When fed an atherogenic diet, mice homozygous for a gene trapped allele show markedly lower VLDL/LDL cholesterol and serum apoB levels, higher cellular oxidative stress, enhanced macrophage immunoreactivity and LDL-induced monocyte chemotaxis, and larger atheromatous lesions than wild-type mice.
 
Interactions
Pon2 interacts with 193 markers (Mir1b, Mir7-1, Mir10a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process aromatic compound catabolic process
Component extracellular region, intracellular membrane-bounded organelle, ...
Function arylesterase activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (158)    Tissues (144)    Images (1)
Theiler Stages: 16, 21, 22, 23, 27, 28
Assay TypeResults
RNA in situ 94
RT-PCR 64
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(13) cDNA(10) Primer pair(3)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000023259 (Evidence)
Ensembl Gene ModelENSMUSG00000032667 (Evidence)
Entrez Gene330260 (Evidence)
DFCITC1575604, TC1666530, TC1674928, TC1732793
DoTSDT.101267836, DT.87069115, DT.97341797, DT.99844809
NIA Mouse Gene IndexU027023
EC3.1.1.2, 3.1.1.81
Consensus CDS ProjectCCDS19900.1
International Mouse Knockout Project StatusPon2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023259 VEGA Gene Model | MGI Sequence Detail 34309 C57BL/6J ±  kb
transcript OTTMUST00000056312 VEGA | MGI Sequence Detail 2409 Not Applicable 
polypeptide OTTMUSP00000027050 VEGA | MGI Sequence Detail 354 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(4) UniProt(2)
Polymorphisms PCR(1) : SNPs within 2kb(157 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002640 Arylesterase
InterPro IPR008364 Paraoxonase2
InterPro IPR011042 Six-bladed beta-propeller, TolB-like
Protein Ontology PR:000013022 serum paraoxonase/arylesterase 2
References (Earliest) J:32894 Primo-Parmo SL, et al., The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family. Genomics. 1996 May 1;33(3):498-507
(Latest) J:205305 Devarajan A, et al., Role of PON2 in innate immune response in an acute infection model. Mol Genet Metab. 2013 Nov;110(3):362-70
All references(46)
Other
accession IDs
MGD-MRK-35146, MGI:1926213, MGI:2141429

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory