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Pon3
Gene Detail
Symbol

Name
ID
Pon3
paraoxonase 3
MGI:106686
Feature Type
protein coding gene
Genetic Map
Chromosome 6
1.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr6:5220852-5256286 bp, - strand
From VEGA annotation of GRCm38

  35435 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37371  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: paraoxonase
Gene Tree: Pon3

Human
homologs
Human Homolog PON3, paraoxonase 3
NCBI Gene ID 5446
neXtProt AC  NX_Q15166
Human Chr (Location)  7q21.3; chr7:95359872-95396375 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit prenatal and postnatal lethality. Mice heterozygous for the same allele exhibit decreased fetal and placental weight.
 
Interactions
Pon3 interacts with 282 markers (Mir1b, Mir10a, Mir17, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (6 records)
Data Summary: Results (226)    Tissues (147)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
Western blot 10
RT-PCR 122
cDNA source data(41)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(46) cDNA(42) Primer pair(4)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000024087 (Evidence)
Ensembl Gene ModelENSMUSG00000029759 (Evidence)
Entrez Gene269823 (Evidence)
UniGene9122
DFCITC1582247, TC1652868, TC1595902
DoTSDT.529904, DT.40151430
NIA Mouse Gene IndexU027022
EC3.1.8.1, 3.1.1.81, 3.1.1.2
Consensus CDS ProjectCCDS19899.1
International Mouse Knockout Project StatusPon3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024087 VEGA Gene Model | MGI Sequence Detail 35435 C57BL/6J ±  kb
transcript OTTMUST00000058914 VEGA | MGI Sequence Detail 1837 Not Applicable 
polypeptide OTTMUSP00000028610 VEGA | MGI Sequence Detail 354 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(6) UniProt(9)
Polymorphisms
SNPs within 2kb(41 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002640 Arylesterase
InterPro IPR008364 Paraoxonase2
InterPro IPR011042 Six-bladed beta-propeller, TolB-like
Protein Ontology PR:000013023 serum paraoxonase/lactonase 3
References
(Earliest) J:32894 Primo-Parmo SL, et al., The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family. Genomics. 1996 May 1;33(3):498-507
(Latest) J:204799 Schweikert EM, et al., PON3 is upregulated in cancer tissues and protects against mitochondrial superoxide-mediated cell death. Cell Death Differ. 2012 Sep;19(9):1549-60
All references(40)
Other
accession IDs
MGD-MRK-35145, MGI:2141470

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory