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Pon3 Gene Detail
Summary
  • Symbol
    Pon3
  • Name
    paraoxonase 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:106686
    NCBI Gene: 269823
  • Gene Overview
    MyGene.info: PON3
Location & Maps
more
  • Genetic Map
    Chromosome 6, 1.99 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    PON3, paraoxonase 3
  • Vertebrate Orthologs
    7
  • Human Ortholog
    PON3, paraoxonase 3
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 5446
    neXtProt AC: NX_Q15166

  • Chr Location
    7q21.3; chr7:95359872-95396375 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit prenatal and postnatal lethality. Mice heterozygous for the same allele exhibit decreased fetal and placental weight.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024087 VEGA Gene Model | MGI Sequence Detail 35435 C57BL/6J ±  kb
transcript OTTMUST00000058914 VEGA | MGI Sequence Detail 1837 Not Applicable  
polypeptide OTTMUSP00000028610 VEGA | MGI Sequence Detail 354 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    41 from dbSNP Build 142
Protein
Information
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Molecular
Reagents
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  • All nucleic 46
    cDNA 42
    Primer pair 4

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-35145, MGI:2141470
References
more
  • Summaries
    All 37
    Developmental Gene Expression 6
    Gene Ontology 7
    Phenotypes 4
  • Earliest
    J:32894 Primo-Parmo SL, et al., The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family. Genomics. 1996 May 1;33(3):498-507
  • Latest
    J:204799 Schweikert EM, et al., PON3 is upregulated in cancer tissues and protects against mitochondrial superoxide-mediated cell death. Cell Death Differ. 2012 Sep;19(9):1549-60

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory