Cd93 MGI Mouse Gene Detail - MGI:106664

Symbol

Cd93
Name

CD93 antigen
Synonyms

6030404G09Rik, AA4.1, C1qr1, C1qrp, Ly68

Feature Type

protein coding gene
IDs

MGI:106664
NCBI Gene: 17064
Gene Overview

MyGene.info: CD93
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr2:148436651-148443535 bp, - strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 73.48 cM
Mapping Data

5 experiments

SNPs within 2kb

54 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_106664	protein coding gene	Chr2:148436640-148443563 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0026608	protein coding gene	Chr2:152779207-152786153 (-)
A/J	MGP_AJ_G0026572	protein coding gene	Chr2:146567600-146574635 (-)
AKR/J	MGP_AKRJ_G0026546	protein coding gene	Chr2:150798537-150806548 (-)
BALB/cJ	MGP_BALBcJ_G0026584	protein coding gene	Chr2:146986217-146993096 (-)
C3H/HeJ	MGP_C3HHeJ_G0026327	protein coding gene	Chr2:151294705-151302121 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0027029	protein coding gene	Chr2:157220370-157228633 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024407	protein coding gene	Chr2:140570977-140577927 (-)
CAST/EiJ	MGP_CASTEiJ_G0025788	protein coding gene	Chr2:151685914-151692391 (-)
CBA/J	MGP_CBAJ_G0026307	protein coding gene	Chr2:162991093-162998003 (-)
DBA/2J	MGP_DBA2J_G0026441	protein coding gene	Chr2:145839065-145845957 (-)
FVB/NJ	MGP_FVBNJ_G0026405	protein coding gene	Chr2:144332354-144339257 (-)
LP/J	MGP_LPJ_G0026545	protein coding gene	Chr2:152895111-152902026 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026425	protein coding gene	Chr2:167062921-167069830 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027084	protein coding gene	Chr2:150801385-150808303 (-)
PWK/PhJ	MGP_PWKPhJ_G0025524	protein coding gene	Chr2:145515900-145522921 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0025325	protein coding gene	Chr2:149774605-149782873 (-)
WSB/EiJ	MGP_WSBEiJ_G0025862	protein coding gene	Chr2:151755800-151763221 (-)

Human Ortholog

CD93, CD93 molecule

Vertebrate Orthologs

10

Human Ortholog

CD93, CD93 molecule
Orthology source: HomoloGene, HGNC
Synonyms

C1QR1, C1qRP, C1qR(P), CDw93, dJ737E23.1, ECSM3, MXRA4
Links

HGNC:15855

NCBI Gene ID: 22918

neXtProt AC: NX_Q9NPY3

UniProt: Q9NPY3
Chr Location

20p11.21; chr20:23076554-23086340 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 7823
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: CD93
Protein SuperFamily

thrombomodulin
Gene Tree

Cd93

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Chemically induced (other)

1
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Cd93
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

1 strains or lines available

Homozygous null mutants have a defect in clearance of apoptotic cells.

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All GO Annotations

12
GO References

6

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

632
Tissues

1
cDNA Data

12
Literature Summary

3

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cd93

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Cd93 interacts with 356 markers (Mir1b, Mir7-1, Mir7-2, ...) View All

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All Sequences

41
RefSeq

2
UniProt

1
CCDS

CCDS16839.1

Ensembl

ENSMUSG00000027435 (Evidence)
NCBI Gene

17064

			Length	Strain/Species	Flank
genomic	17064	NCBI Gene Model \| MGI Sequence Detail	6885	C57BL/6J	± kb
transcript	NM_010740	RefSeq \| MGI Sequence Detail	6638	C57BL/6
polypeptide	O89103	UniProt \| EBI \| MGI Sequence Detail	644	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000002037 complement component C1q receptor

(term hierarchy)
InterPro Domains

IPR026823 Complement Clr-like EGF domain

IPR016187 C-type lectin fold

IPR001304 C-type lectin-like

IPR016186 C-type lectin-like/link domain superfamily

IPR018097 EGF-like calcium-binding, conserved site

IPR001881 EGF-like calcium-binding domain

IPR000742 EGF-like domain

IPR000152 EGF-type aspartate/asparagine hydroxylation site

IPR009030 Growth factor receptor cysteine-rich domain superfamily

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All nucleic 13

cDNA 12

Primer pair 1

Microarray probesets 6

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MGD-MRK-35123, MGI:1924392, MGI:2139398, MGI:2668130

Summaries

All 52

Developmental Gene Expression 3

Gene Ontology 6

Phenotypes 16
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:287626 Liang Q, et al., CD93 negatively regulates astrogenesis in response to MMRN2 through the transcriptional repressor ZFP503 in the developing brain. Proc Natl Acad Sci U S A. 2020 Apr 28;117(17):9413-9422

TSS for Cd93:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr26666	Chr2:148443624-148443626 (-)	-90 bp
Tssr26665	Chr2:148443543-148443582 (-)	-28 bp
Tssr26664	Chr2:148443530-148443542 (-)	-1 bp
Tssr26663	Chr2:148443509-148443520 (-)	20 bp
Tssr26662	Chr2:148443429-148443444 (-)	98 bp
Tssr26660	Chr2:148440893-148440914 (-)	2,631 bp
Tssr26658	Chr2:148439800-148439814 (-)	3,728 bp
Tssr26657	Chr2:148438440-148438453 (-)	5,088 bp
Tssr26656	Chr2:148438396-148438414 (-)	5,130 bp
Tssr26655	Chr2:148438256-148438275 (-)	5,269 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 02/23/2021 MGI 6.16