Cd93 MGI Mouse Gene Detail - MGI:106664

Cd93 Gene Detail

Symbol

Cd93
Name

CD93 antigen
Synonyms

6030404G09Rik, AA4.1, C1qr1, C1qrp, Ly68

Feature Type

protein coding gene
IDs

MGI:106664
NCBI Gene: 17064
Gene Overview

MyGene.info: CD93

Sequence Map

Chr2:148436640-148443563 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

6924 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 73.48 cM
Mapping Data

5 experiments

Human Ortholog

CD93, CD93 molecule

Vertebrate Orthologs

10

Human Ortholog

CD93, CD93 molecule
Orthology source: HomoloGene, HGNC
Synonyms

C1QR1, C1qRP, C1qR(P), CDw93, dJ737E23.1, ECSM3, MXRA4
Links

HGNC:15855

NCBI Gene ID: 22918

neXtProt AC: NX_Q9NPY3

UniProt: Q9NPY3
Chr Location

20p11.21; chr20:23076554-23086340 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 7823
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: CD93
Protein SuperFamily

thrombomodulin
Gene Tree

Cd93

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Chemically induced (other)

1
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Cd93
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

6 strains or lines available

Homozygous null mutants have a defect in clearance of apoptotic cells.

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All GO Annotations

13
GO References

6

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1
Tissues

1
cDNA Data

11
Literature Summary

2

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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Cd93 interacts with 356 markers (Mir1b, Mir7-1, Mir7-2, ...) View All

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All Sequences

28
RefSeq

2
UniProt

1
CCDS

CCDS16839.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000015713	VEGA Gene Model \| MGI Sequence Detail	6924	C57BL/6J	± kb
transcript	OTTMUST00000037332	VEGA \| MGI Sequence Detail	6677	Not Applicable
polypeptide	OTTMUSP00000016723	VEGA \| MGI Sequence Detail	644	Not Applicable

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SNPs within 2kb

54 from dbSNP Build 142

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UniProt

1 Sequence
Protein Ontology

PR:000002037 complement component C1q receptor

(term hierarchy)
InterPro Domains

IPR026823 Complement Clr-like EGF domain

IPR016187 C-type lectin fold

IPR001304 C-type lectin-like

IPR016186 C-type lectin-like/link domain

IPR018097 EGF-like calcium-binding, conserved site

IPR001881 EGF-like calcium-binding domain

IPR013032 EGF-like, conserved site

IPR000742 EGF-like domain

IPR000152 EGF-type aspartate/asparagine hydroxylation site

IPR009030 Growth factor receptor cysteine-rich domain

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All nucleic 12

cDNA 11

Primer pair 1

Microarray probesets 6

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MGD-MRK-35123, MGI:1924392, MGI:2139398, MGI:2668130

Summaries

All 49

Developmental Gene Expression 2

Gene Ontology 6

Phenotypes 14
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:240507 Strawbridge RJ, et al., Soluble CD93 Is Involved in Metabolic Dysregulation but Does Not Influence Carotid Intima-Media Thickness. Diabetes. 2016 Oct;65(10):2888-99

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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