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Trim21 Gene Detail
Summary
  • Symbol
    Trim21
  • Name
    tripartite motif-containing 21
  • Synonyms
    Ro52, Ssa1
  • Feature Type
    protein coding gene
  • IDs
    MGI:106657
    NCBI Gene: 20821
  • Gene Overview
    MyGene.info: TRIM21
Location & Maps
more
  • Sequence Map
    Chr7:102557922-102565469 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7548 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    TRIM21, tripartite motif containing 21
  • Vertebrate Orthologs
    7
  • Human Ortholog
    TRIM21, tripartite motif containing 21
    Orthology source: HGNC, HomoloGene
  • Synonyms
    RNF81, RO52, Ro/SSA, SSA, SSA1
  • Links
    NCBI Gene ID: 6737
    neXtProt AC: NX_P19474

  • Chr Location
    11p15.5; chr11:4384897-4393712 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    4 images
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Trim21
  • Incidental Mutations
    APF
Unmanipulated homozygous mice are normal, but leads to tissue inflammation and systemic autoimmunity in vivo and reduced number of CD11c+ dendritic cells from mutant bone marrow in vitro.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030966 Ensembl Gene Model | MGI Sequence Detail 7548 C57BL/6J ±  kb
transcript ENSMUST00000033264 Ensembl | MGI Sequence Detail 2775 Not Applicable  
polypeptide ENSMUSP00000033264 Ensembl | MGI Sequence Detail 462 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    175 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 41
    cDNA 41

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-35115
References
more
  • Summaries
    All 36
    Developmental Gene Expression 4
    Gene Ontology 7
    Phenotypes 18
  • Earliest
    J:32812 Keech CL, et al., Structural differences between the human and mouse 52-kD Ro autoantigens associated with poorly conserved autoantibody activity across species. Clin Exp Immunol. 1996 May;104(2):255-63
  • Latest
    J:216388 Bidgood SR, et al., Translocalized IgA mediates neutralization and stimulates innate immunity inside infected cells. Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13463-8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory