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Trim21
Gene Detail
Symbol

Name
ID
Trim21
tripartite motif-containing 21
MGI:106657
Synonyms
Ro52, Ssa1
Feature Type
protein coding gene
Genetic Map
Chromosome 7
54.76 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr7:102557922-102565469 bp, - strand
From Ensembl annotation of GRCm38

  7548 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2365  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: TRIM21
Protein SuperFamily: tripartite motif-containing protein
Gene Tree: Trim21

Human
homologs
TRIM21, tripartite motif containing 21
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 6737
neXtProt AC: NX_P19474

Human Synonyms: RNF81, RO52, Ro/SSA, SSA, SSA1

Human Chr (Location): 11p15.5; chr11:4384897-4393712 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from APF )
 
Unmanipulated homozygous mice are normal, but leads to tissue inflammation and systemic autoimmunity in vivo and reduced number of CD11c+ dendritic cells from mutant bone marrow in vitro.
 
Interactions
Trim21 interacts with 169 markers (Mir7-1, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (41 annotations)
Process cell cycle, innate immune response, ...
Component cytoplasm, intracellular, ...
Function coenzyme F420-0 gamma-glutamyl ligase activity, coenzyme F420-2 alpha-glutamyl ligase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (117)    Tissues (78)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 117
cDNA source data(41)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(41) cDNA(41)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000030966 (Evidence)
Entrez Gene 20821 (Evidence)
UniGene 321227
DFCI TC1580325
DoTS DT.101342135, DT.110987661, DT.529304
NIA Mouse Gene Index U028946
EC 6.3.2.-
PDB 2VOK, 3ZO0
Consensus CDS Project CCDS40051.1
International Mouse Phenotyping Consortium Status Trim21
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030966 Ensembl Gene Model | MGI Sequence Detail 7548 C57BL/6J ±  kb
transcript ENSMUST00000033264 Ensembl | MGI Sequence Detail 2775 Not Applicable 
polypeptide ENSMUSP00000033264 Ensembl | MGI Sequence Detail 462 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(4) UniProt(4)
Polymorphisms
SNPs within 2kb(174 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001870 B30.2/SPRY domain
InterPro IPR003879 Butyrophylin-like
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
InterPro IPR003877 SPla/RYanodine receptor SPRY
InterPro IPR006574 SPRY-associated
InterPro IPR000315 Zinc finger, B-box
InterPro IPR020457 Zinc finger, B-box, chordata
InterPro IPR018957 Zinc finger, C3HC4 RING-type
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR001841 Zinc finger, RING-type
InterPro IPR017907 Zinc finger, RING-type, conserved site
Protein Ontology PR:000016647 E3 ubiquitin-protein ligase TRIM21
References
(Earliest) J:32812 Keech CL, et al., Structural differences between the human and mouse 52-kD Ro autoantigens associated with poorly conserved autoantibody activity across species. Clin Exp Immunol. 1996 May;104(2):255-63
(Latest) J:216388 Bidgood SR, et al., Translocalized IgA mediates neutralization and stimulates innate immunity inside infected cells. Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13463-8
All references(39)
Other
accession IDs
MGD-MRK-35115

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory