Trim21
Gene Detail

Symbol Name ID

Trim21 tripartite motif-containing 21 MGI:106657

Synonyms

Ro52, Ssa1

Feature Type

protein coding gene

Genetic Map

Chromosome 7

54.76 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr7:102557922-102565469 bp, - strand From NCBI annotation of GRCm38   7548 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2365  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: tripartite motif-containing protein
Gene Tree: Trim21

Human homologs

Human Homolog		TRIM21, tripartite motif containing 21
NCBI Gene ID		6737
neXtProt AC		NX_P19474
Human Synonyms		RNF81, RO52, SSA, SSA1
Human Chr (Location)		11p15.5; chr11:4406127-4414926 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Unmanipulated homozygous mice are normal, but leads to tissue inflammation and systemic autoimmunity in vivo and reduced number of CD11c+ dendritic cells from mutant bone marrow in vitro.

 

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	cell cycle, negative regulation of NF-kappaB transcription factor activity, ...
Component	cytoplasm, intracellular, ...
Function	DNA binding, ligase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (117)    Tissues (70)    Images (24)
Theiler Stages: 16, 17, 19, 21, 23, 28

Assay Type	Results
RNA in situ	117

cDNA source data(41)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(41) cDNA(41)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000030966 (Evidence)
Entrez Gene	20821 (Evidence)
UniGene	321227
DFCI	TC1580325
DoTS	DT.101342135, DT.110987661, DT.529304
NIA Mouse Gene Index	U028946
EC	6.3.2.-
PDB	2VOK, 2VOL
Consensus CDS Project	CCDS40051.1
International Mouse Knockout Project Status	Trim21

Sequences

Length	Strain/Species
genomic	20821	NCBI Gene Model | MGI Sequence Detail	7548	C57BL/6J
transcript	NM_009277	RefSeq | MGI Sequence Detail	2775	C57BL/6
polypeptide	Q62191	UniProt | EBI | MGI Sequence Detail	470	Not Applicable

All sequences(29) RefSeq(4) UniProt(4)

Polymorphisms

SNPs(103 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001870	B30.2/SPRY domain
InterPro	IPR003879	Butyrophylin-like
InterPro	IPR008985	Concanavalin A-like lectin/glucanases superfamily
InterPro	IPR003877	SPla/RYanodine receptor SPRY
InterPro	IPR018355	SPla/RYanodine receptor subgroup
InterPro	IPR006574	SPRY-associated
InterPro	IPR000315	Zinc finger, B-box
InterPro	IPR020457	Zinc finger, B-box, chordata
InterPro	IPR013083	Zinc finger, RING/FYVE/PHD-type
InterPro	IPR001841	Zinc finger, RING-type
InterPro	IPR017907	Zinc finger, RING-type, conserved site
Protein Ontology	PR:000016647	E3 ubiquitin-protein ligase TRIM21

Graphical View of Protein Domain Structure

References

(Earliest) J:32812 Keech CL, et al., Structural differences between the human and mouse 52-kD Ro autoantigens associated with poorly conserved autoantibody activity across species. Clin Exp Immunol. 1996 May;104(2):255-63
(Latest) J:192552 Zhang Z, et al., The E3 ubiquitin ligase TRIM21 negatively regulates the innate immune response to intracellular double-stranded DNA. Nat Immunol. 2012 Dec 9;14(2):172-8
All references(36)

Other accession IDs

MGD-MRK-35115