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Trim21 Gene Detail
Summary
  • Symbol
    Trim21
  • Name
    tripartite motif-containing 21
  • Synonyms
    Ro52, Ssa1
  • Feature Type
    protein coding gene
  • IDs
    MGI:106657
    NCBI Gene: 20821
  • Gene Overview
    MyGene.info: TRIM21
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr7:102557921-102565486 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7566 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 54.76 cM, cytoband F1
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    TRIM21, tripartite motif containing 21
  • Vertebrate Orthologs
    7
  • Human Ortholog
    TRIM21, tripartite motif containing 21
    Orthology source: HomoloGene, HGNC
  • Synonyms
    RNF81, RO52, Ro/SSA, SSA, SSA1
  • Links
    NCBI Gene ID: 6737
    neXtProt AC: NX_P19474
    UniProt: P19474

  • Chr Location
    11p15.4; chr11:4384897-4393696 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    4 images
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Unmanipulated homozygous mice are normal, but leads to tissue inflammation and systemic autoimmunity in vivo and reduced number of CD11c+ dendritic cells from mutant bone marrow in vitro.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000060441 VEGA Gene Model | MGI Sequence Detail 7566 C57BL/6J ±  kb
    transcript OTTMUST00000147894 VEGA | MGI Sequence Detail 2793 Not Applicable  
    polypeptide OTTMUSP00000076936 VEGA | MGI Sequence Detail 462 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      175 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 41
      cDNA 41

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-35115
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 4
      Gene Ontology 7
      Phenotypes 24
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:260699 Encheva V, et al., Murine Gbp1 and Gbp2 are ubiquitinated independent of Toxoplasma gondii infection. BMC Res Notes. 2018 Mar 6;11(1):166

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory