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Trim21
Gene Detail
 Symbol
Name
ID
Trim21
tripartite motif-containing 21
MGI:106657
Synonyms Ro52, Ssa1
Feature Type protein coding gene
Genetic Map
Chromosome 7
54.76 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr7:102557922-102565469 bp, - strand
From NCBI annotation of GRCm38

  7548 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2365  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: tripartite motif-containing protein
Gene Tree: Trim21

Human
homologs
Human Homolog TRIM21, tripartite motif containing 21
NCBI Gene ID 6737
neXtProt AC  NX_P19474
Human Synonyms  RNF81, RO52, Ro/SSA, SSA, SSA1
Human Chr (Location)  11p15.5; chr11:4384897-4393697 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from APF )
 
Unmanipulated homozygous mice are normal, but leads to tissue inflammation and systemic autoimmunity in vivo and reduced number of CD11c+ dendritic cells from mutant bone marrow in vitro.
 
Interactions
Trim21 interacts with 169 markers (Mir7-1, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (39 annotations)
Process cell cycle, innate immune response, ...
Component cytoplasm, intracellular, ...
Function coenzyme F420-0 gamma-glutamyl ligase activity, coenzyme F420-2 alpha-glutamyl ligase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (117)    Tissues (78)    Images (24)
Theiler Stages: 16, 17, 19, 21, 23, 27, 28
Assay TypeResults
RNA in situ 117
cDNA source data(41)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(41) cDNA(41)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000030966 (Evidence)
Entrez Gene20821 (Evidence)
UniGene321227
DFCITC1580325
DoTSDT.101342135, DT.110987661, DT.529304
NIA Mouse Gene IndexU028946
EC6.3.2.-
PDB2VOK, 3ZO0
Consensus CDS ProjectCCDS40051.1
International Mouse Knockout Project StatusTrim21
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 20821 NCBI Gene Model | MGI Sequence Detail 7548 C57BL/6J ±  kb
transcript NM_009277 RefSeq | MGI Sequence Detail 2790 C57BL/6 
polypeptide Q62191 UniProt | EBI | MGI Sequence Detail 470 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(4) UniProt(4)
Polymorphisms SNPs within 2kb(174 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001870 B30.2/SPRY domain
InterPro IPR003879 Butyrophylin-like
InterPro IPR008985 Concanavalin A-like lectin/glucanases superfamily
InterPro IPR003877 SPla/RYanodine receptor SPRY
InterPro IPR018355 SPla/RYanodine receptor subgroup
InterPro IPR006574 SPRY-associated
InterPro IPR000315 Zinc finger, B-box
InterPro IPR020457 Zinc finger, B-box, chordata
InterPro IPR018957 Zinc finger, C3HC4 RING-type
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR001841 Zinc finger, RING-type
InterPro IPR017907 Zinc finger, RING-type, conserved site
Protein Ontology PR:000016647 E3 ubiquitin-protein ligase TRIM21
Graphical View of Protein Domain Structure
References (Earliest) J:32812 Keech CL, et al., Structural differences between the human and mouse 52-kD Ro autoantigens associated with poorly conserved autoantibody activity across species. Clin Exp Immunol. 1996 May;104(2):255-63
(Latest) J:194820 McEwan WA, et al., Intracellular antibody-bound pathogens stimulate immune signaling via the Fc receptor TRIM21. Nat Immunol. 2013 Apr;14(4):327-36
All references(39)
Other
accession IDs
MGD-MRK-35115

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory