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Zan-test
Gene Detail
Symbol

Name
ID
Zan-test
zonadhesin
MGI:106656
Synonyms
Zan
Feature Type
protein coding gene
Genetic Map
Chromosome 5
76.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr5:137378637-137477064 bp, - strand
From VEGA annotation of GRCm38

  98428 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:124417  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle

HCOP human homology predictions: ZAN
Gene Tree: Zan-test

Human
homologs
ZAN, zonadhesin (gene/pseudogene)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 7455
neXtProt AC: NX_Q9Y493

Human Chr (Location): 7q22; chr7:100733583-100797797 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(3) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Sperm from mice homozygous for a knock-out allele exhibit decreased species-specific zona pellucida adhesion without alteration in fertility.
 
Interactions
Zan-test interacts with 45 markers (Mir1b, Mir34b, Mir34c, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process binding of sperm to zona pellucida, cell adhesion, ...
Component integral component of membrane, membrane, ...
Function extracellular matrix binding
External Resources: FuncBase
Expression
cDNA source data(4)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100497422    NEW 
Molecular
reagents
All nucleic(5) Genomic(1) cDNA(4)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000030088 (Evidence)
Ensembl Gene Model ENSMUSG00000079173 (Evidence)
Entrez Gene 22635 (Evidence)
UniGene 7984
DFCI TC1591559
DoTS DT.101352879, DT.87048450
NIA Mouse Gene Index U026845
Consensus CDS Project CCDS51672.1
International Mouse Phenotyping Consortium Status Zan-test
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030088 VEGA Gene Model | MGI Sequence Detail 98428 C57BL/6J ±  kb
transcript OTTMUST00000074539 VEGA | MGI Sequence Detail 16481 Not Applicable 
polypeptide OTTMUSP00000038870 VEGA | MGI Sequence Detail 5420 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(8) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(604 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013320 Concanavalin A-like lectin/glucanase domain
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000742 EGF-like domain
InterPro IPR003645 Follistatin-like, N-terminal
InterPro IPR000998 MAM domain
InterPro IPR025615 TILa domain
InterPro IPR002919 Trypsin Inhibitor-like, cysteine rich domain
InterPro IPR014853 Uncharacterised domain, cysteine-rich
InterPro IPR001846 von Willebrand factor, type D domain
InterPro IPR001007 VWFC domain
Protein Ontology PR:000017557 zonadhesin
References
(Earliest) J:33454 Hardy DM, et al., A sperm membrane protein that binds in a species-specific manner to the egg extracellular matrix is homologous to von Willebrand factor. J Biol Chem. 1995 Nov 3;270(44):26025-8
(Latest) J:172046 Wheeler K, et al., Regulatory T cells control tolerogenic versus autoimmune response to sperm in vasectomy. Proc Natl Acad Sci U S A. 2011 May 3;108(18):7511-6
All references(34)
Other
accession IDs
MGD-MRK-35114

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory