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Zan Gene Detail
Summary
  • Symbol
    Zan
  • Name
    zonadhesin
  • Synonyms
    Zan
  • Feature Type
    protein coding gene
  • IDs
    MGI:106656
    NCBI Gene: 22635
Location & Maps
more
  • Sequence Map
    Chr5:137378637-137477064 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      98428 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 76.40 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    ZAN, zonadhesin (gene/pseudogene)
  • Vertebrate Orthologs
    6
  • Human Ortholog
    ZAN, zonadhesin (gene/pseudogene)
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 7455
    neXtProt AC: NX_Q9Y493

  • Chr Location
    7q22; chr7:100733583-100797797 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 2 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Sperm from mice homozygous for a knock-out allele exhibit decreased species-specific zona pellucida adhesion without alteration in fertility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030088 VEGA Gene Model | MGI Sequence Detail 98428 C57BL/6J ±  kb
transcript OTTMUST00000074539 VEGA | MGI Sequence Detail 16481 Not Applicable  
polypeptide OTTMUSP00000038870 VEGA | MGI Sequence Detail 5420 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    593 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 5
    Genomic 1
    cDNA 4

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-35114
References
more
  • Summaries
    All 29
    Gene Ontology 4
    Phenotypes 6
  • Earliest
    J:33454 Hardy DM, et al., A sperm membrane protein that binds in a species-specific manner to the egg extracellular matrix is homologous to von Willebrand factor. J Biol Chem. 1995 Nov 3;270(44):26025-8
  • Latest
    J:172046 Wheeler K, et al., Regulatory T cells control tolerogenic versus autoimmune response to sperm in vasectomy. Proc Natl Acad Sci U S A. 2011 May 3;108(18):7511-6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory