Trove2
Gene Detail

Symbol Name ID

Trove2 TROVE domain family, member 2 MGI:106652

Synonyms

1810007I17Rik, A530054J02Rik, Ssa, Ssa2, SS-A/Ro

Feature Type

protein coding gene

Genetic Map

Chromosome 1

62.54 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr1:143750790-143777068 bp, - strand From VEGA annotation of GRCm38   26279 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3383  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Trove2

Human homologs

Human Homolog		TROVE2, TROVE domain family, member 2
NCBI Gene ID		6738
neXtProt AC		NX_P10155
Human Synonyms		RO60, RORNP, SSA2
Human Chr (Location)		1q31; chr1:193028552-193060907 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(10) : Targeted(4) Gene trapped(6)
 

Homozygous mutant mice develop symptoms similar to those observed in patients with lupus, including increased photosensitivity and membranoproliferative glomerulonephritis. The production of autoantibodies is detected in both homozygous and heterozygous mutant mice.

 
Human Diseases Modeled Using Mouse Trove2 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (7 annotations)

Process	cell projection organization, cilium morphogenesis
Component	cytoplasm, nucleus, ...
Function	nucleic acid binding, RNA binding

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (2)    Tissues (2)    Images (2)
Theiler Stages: 11, 13

Assay Type	Results
RNA in situ	2

cDNA source data(76)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(76) cDNA(76)
Microarray probesets(9)

Other database links

VEGA Gene Model	OTTMUSG00000021864 (Evidence)
Ensembl Gene Model	ENSMUSG00000018199 (Evidence)
Entrez Gene	20822 (Evidence)
UniGene	40370
DFCI	TC1577583, TC1647405, TC1656444, TC1704103, TC1711792
DoTS	DT.101127827, DT.110939245, DT.40155154, DT.60101572
NIA Mouse Gene Index	U021853
Consensus CDS Project	CCDS15345.1
International Mouse Knockout Project Status	Trove2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021864	VEGA Gene Model | MGI Sequence Detail	26279	C57BL/6J
transcript	OTTMUST00000051883	VEGA | MGI Sequence Detail	8738	Not Applicable
polypeptide	OTTMUSP00000024494	VEGA | MGI Sequence Detail	538	Not Applicable

All sequences(52) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(168 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008858	TROVE
Protein Ontology	PR:000016692	60 kDa SS-A/Ro ribonucleoprotein

References

(Earliest) J:32812 Keech CL, et al., Structural differences between the human and mouse 52-kD Ro autoantigens associated with poorly conserved autoantibody activity across species. Clin Exp Immunol. 1996 May;104(2):255-63
(Latest) J:182871 Lai CK, et al., Functional characterization of putative cilia genes by high-content analysis. Mol Biol Cell. 2011 Apr;22(7):1104-19
All references(44)

Other accession IDs

MGD-MRK-14606, MGD-MRK-35110, MGI:1916306, MGI:2138306, MGI:2443501