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Trove2
Gene Detail
Symbol

Name
ID
Trove2
TROVE domain family, member 2
MGI:106652
Synonyms
1810007I17Rik, A530054J02Rik, Ssa, Ssa2, SS-A/Ro
Feature Type
protein coding gene
Genetic Map
Chromosome 1
62.54 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr1:143750790-143777068 bp, - strand
From VEGA annotation of GRCm38

  26279 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3383  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Trove2

Human
homologs
Human Homolog TROVE2, TROVE domain family, member 2
NCBI Gene ID 6738
neXtProt AC  NX_P10155
Human Synonyms  RO60, RORNP, SSA2
Human Chr (Location)  1q31; chr1:193059422-193091777 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(6) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice develop symptoms similar to those observed in patients with lupus, including increased photosensitivity and membranoproliferative glomerulonephritis. The production of autoantibodies is detected in both homozygous and heterozygous mutant mice.
 
Human Diseases Modeled Using Mouse Trove2 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)
Interactions
Trove2 interacts with 520 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process cell projection organization, cilium morphogenesis, ...
Component cytoplasm, nucleoplasm, ...
Function metal ion binding, misfolded RNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (2)    Tissues (2)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 2
cDNA source data(76)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(76) cDNA(76)
Microarray probesets(9)
Other database
links
VEGA Gene ModelOTTMUSG00000021864 (Evidence)
Ensembl Gene ModelENSMUSG00000018199 (Evidence)
Entrez Gene20822 (Evidence)
UniGene40370
DFCITC1656444, TC1704103, TC1647405, TC1577583, TC1711792
DoTSDT.40155154, DT.110939245, DT.101127827, DT.60101572
NIA Mouse Gene IndexU021853
Consensus CDS ProjectCCDS15345.1
International Mouse Knockout Project StatusTrove2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021864 VEGA Gene Model | MGI Sequence Detail 26279 C57BL/6J ±  kb
transcript OTTMUST00000051883 VEGA | MGI Sequence Detail 8738 Not Applicable 
polypeptide OTTMUSP00000024494 VEGA | MGI Sequence Detail 538 Not Applicable 

For the selected sequences
All sequences(57) RefSeq(4) UniProt(7)
Polymorphisms
SNPs within 2kb(204 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008858 TROVE
InterPro IPR002035 von Willebrand factor, type A
Protein Ontology PR:000016692 60 kDa SS-A/Ro ribonucleoprotein
References
(Earliest) J:32812 Keech CL, et al., Structural differences between the human and mouse 52-kD Ro autoantigens associated with poorly conserved autoantibody activity across species. Clin Exp Immunol. 1996 May;104(2):255-63
(Latest) J:182871 Lai CK, et al., Functional characterization of putative cilia genes by high-content analysis. Mol Biol Cell. 2011 Apr;22(7):1104-19
All references(45)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-14606, MGD-MRK-35110, MGI:1916306, MGI:2138306, MGI:2443501

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory