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Trove2 Gene Detail
Summary
  • Symbol
    Trove2
  • Name
    TROVE domain family, member 2
  • Synonyms
    1810007I17Rik, A530054J02Rik, Ssa, Ssa2, SS-A/Ro
  • Feature Type
    protein coding gene
  • IDs
    MGI:106652
    NCBI Gene: 20822
  • Gene Overview
    MyGene.info: TROVE2
Location & Maps
more
  • Sequence Map
    Chr1:143750790-143777068 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      26279 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 62.54 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    TROVE2, TROVE domain family member 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TROVE2, TROVE domain family member 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    RO60, RORNP, SSA2
  • Links
    NCBI Gene ID: 6738
    neXtProt AC: NX_P10155

  • Chr Location
    1q31.2; chr1:193059422-193091777 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Trove2 mouse models

Human Disease Mouse Models
       Systemic Lupus Erythematosus; SLE   OMIM: 152700 View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 1 allele in 2 genetic backgrounds
    1 images
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Chemically induced (other)
    2
  • Gene trapped
    6
  • Targeted
    4
  • Genomic Mutations
    2 involving Trove2
  • Incidental Mutations
Homozygous mutant mice develop symptoms similar to those observed in patients with lupus, including increased photosensitivity and membranoproliferative glomerulonephritis. The production of autoantibodies is detected in both homozygous and heterozygous mutant mice.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021864 VEGA Gene Model | MGI Sequence Detail 26279 C57BL/6J ±  kb
transcript OTTMUST00000051883 VEGA | MGI Sequence Detail 8738 Not Applicable  
polypeptide OTTMUSP00000024494 VEGA | MGI Sequence Detail 538 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    204 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 76
    cDNA 76

    Microarray probesets 9
Other
Accession IDs
less
MGD-MRK-14606, MGD-MRK-35110, MGI:1916306, MGI:2138306, MGI:2443501
References
more
  • Summaries
    All 43
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 6
    Phenotypes 9
  • Earliest
    J:32812 Keech CL, et al., Structural differences between the human and mouse 52-kD Ro autoantigens associated with poorly conserved autoantibody activity across species. Clin Exp Immunol. 1996 May;104(2):255-63
  • Latest
    J:233532 Scekic-Zahirovic J, et al., Toxic gain of function from mutant FUS protein is crucial to trigger cell autonomous motor neuron loss. EMBO J. 2016 May 17;35(10):1077-97

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory