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Trove2 Gene Detail
Summary
  • Symbol
    Trove2
  • Name
    TROVE domain family, member 2
  • Synonyms
    1810007I17Rik, A530054J02Rik, Ssa, Ssa2, SS-A/Ro
  • Feature Type
    protein coding gene
  • IDs
    MGI:106652
    NCBI Gene: 20822
  • Gene Overview
    MyGene.info: RO60
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:143750790-143777058 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 62.54 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    204 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106652
protein coding gene Chr1:143750790-143777068 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016563
protein coding gene Chr1:148106617-148134529 (-)
A/J MGP_AJ_G0016546
protein coding gene Chr1:142198744-142226678 (-)
AKR/J MGP_AKRJ_G0016511
protein coding gene Chr1:146563932-146593216 (-)
BALB/cJ MGP_BALBcJ_G0016506
protein coding gene Chr1:142623292-142650263 (-)
C3H/HeJ MGP_C3HHeJ_G0016331
protein coding gene Chr1:146682018-146708456 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016967
protein coding gene Chr1:153099507-153125733 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014676
protein coding gene Chr1:135011598-135038074 (-)
CAST/EiJ MGP_CASTEiJ_G0015910
protein coding gene Chr1:146103180-146130359 (-)
CBA/J MGP_CBAJ_G0016305
protein coding gene Chr1:158539370-158570501 (-)
DBA/2J MGP_DBA2J_G0016411
protein coding gene Chr1:141296616-141323501 (-)
FVB/NJ MGP_FVBNJ_G0016409
protein coding gene Chr1:139788291-139814019 (-)
LP/J MGP_LPJ_G0016482
protein coding gene Chr1:149121236-149148610 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016435
protein coding gene Chr1:164970806-164997621 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017003
protein coding gene Chr1:146293050-146319507 (-)
PWK/PhJ MGP_PWKPhJ_G0015696
protein coding gene Chr1:140208540-140235173 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015483
protein coding gene Chr1:145089641-145119853 (-)
WSB/EiJ MGP_WSBEiJ_G0015973
protein coding gene Chr1:146330224-146356394 (-)



Homology
more
  • Human Ortholog
    RO60, Ro60, Y RNA binding protein
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RO60, Ro60, Y RNA binding protein
    Orthology source: HGNC, HomoloGene
  • Synonyms
    RORNP, SSA2, TROVE2
  • Links
    NCBI Gene ID: 6738
    neXtProt AC: NX_P10155
    UniProt: P10155

  • Chr Location
    1q31.2; chr1:193059422-193091777 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Trove2 mouse models

Human Disease Mouse Models
      
IDs
View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 1 allele in 2 genetic backgrounds
    1 images
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutant mice develop symptoms similar to those observed in patients with lupus, including increased photosensitivity and membranoproliferative glomerulonephritis. The production of autoantibodies is detected in both homozygous and heterozygous mutant mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20822 NCBI Gene Model | MGI Sequence Detail 26269 C57BL/6J ±  kb
    transcript NM_013835 RefSeq | MGI Sequence Detail 8736 C57BL/6  
    polypeptide O08848 UniProt | EBI | MGI Sequence Detail 538 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 77
      cDNA 77

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGD-MRK-14606, MGD-MRK-35110, MGI:1916306, MGI:2138306, MGI:2443501
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 8
      Phenotypes 9
    • Earliest
      J:32812 Keech CL, et al., Structural differences between the human and mouse 52-kD Ro autoantigens associated with poorly conserved autoantibody activity across species. Clin Exp Immunol. 1996 May;104(2):255-63
    • Latest
      J:233532 Scekic-Zahirovic J, et al., Toxic gain of function from mutant FUS protein is crucial to trigger cell autonomous motor neuron loss. EMBO J. 2016 May 17;35(10):1077-97

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory