About   Help   FAQ
Ly6e
Gene Detail
Symbol

Name
ID
Member of
Ly6e
lymphocyte antigen 6 complex, locus E
MGI:106651
Ly6 cluster
Synonyms
9804, Ly67, RIG-E, Sca-2, Tsa1, TSA-1
Feature Type
protein coding gene
Genetic Map
Chromosome 15
34.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr15:74955051-74959903 bp, + strand
From VEGA annotation of GRCm38

  4853 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56411  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 3 chicken

HCOP human homology predictions: LY6E
Protein SuperFamily: Ly-6-like protein
Gene Tree: Ly6e

Human
homologs
LY6E, lymphocyte antigen 6 complex, locus E
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 4061
neXtProt AC: NX_Q16553

Human Synonyms: RIGE, RIG-E, SCA2, SCA-2, TSA-1

Human Chr (Location): 8q24.3; chr8:143018485-143022410 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(4) Radiation induced(1) Targeted(4)
Genomic Mutations involving Ly6e (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene die as embryos as a result of heart defects.
 
Phenotype Images(2)
Interactions
Ly6e interacts with 171 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process adrenal gland development, epinephrine secretion, ...
Component anchored component of membrane, cell, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (85)    Tissues (8)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 85
cDNA source data(889)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(893) Genomic(1) cDNA(891) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000045205 (Evidence)
Ensembl Gene Model ENSMUSG00000022587 (Evidence)
Entrez Gene 17069 (Evidence)
UniGene 788
DFCI TC1716985, TC1600794, TC1573829
DoTS DT.50316237, DT.94282970, DT.97362492, DT.94309309, DT.94283009
NIA Mouse Gene Index U016341
Consensus CDS Project CCDS27538.1
International Mouse Phenotyping Consortium Status Ly6e
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000045205 VEGA Gene Model | MGI Sequence Detail 4853 C57BL/6J ±  kb
transcript OTTMUST00000118765 VEGA | MGI Sequence Detail 1122 Not Applicable 
polypeptide OTTMUSP00000066259 VEGA | MGI Sequence Detail 136 Not Applicable 

For the selected sequences
All sequences(105) RefSeq(12) UniProt(9)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(52 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001526 CD59 antigen
InterPro IPR016054 Ly-6 antigen / uPA receptor -like
Protein Ontology PR:000009989 lymphocyte antigen 6E
References
(Earliest) J:16061 MacNeil I, et al., Isolation of a cDNA encoding thymic shared antigen-1. A new member of the Ly6 family with a possible role in T cell development. J Immunol. 1993 Dec 15;151(12):6913-23
(Latest) J:200767 Hughes M, et al., Ly6e expression is restricted to syncytiotrophoblast cells of the mouse placenta. Placenta. 2013 Sep;34(9):831-5
All references(40)
Other
accession IDs
MGD-MRK-15264, MGD-MRK-35109

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/23/2015
MGI 5.22
The Jackson Laboratory