About   Help   FAQ
Take the Alliance for Genomic Resources User Survey
Ly6e Gene Detail
Summary
  • Symbol
    Ly6e
  • Name
    lymphocyte antigen 6 complex, locus E
  • Synonyms
    9804, Ly67, RIG-E, Sca-2, Tsa1, TSA-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:106651
    NCBI Gene: 17069
  • Member of
    Ly6 cluster
  • Gene Overview
    MyGene.info: LY6E
Location & Maps
more
  • Sequence Map
    Chr15:74955051-74959903 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      4853 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 34.29 cM
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    LY6E, lymphocyte antigen 6 complex, locus E
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LY6E, lymphocyte antigen 6 complex, locus E
    Orthology source: HomoloGene, HGNC
  • Synonyms
    RIGE, RIG-E, SCA2, SCA-2, TSA-1
  • Links
    NCBI Gene ID: 4061
    neXtProt AC: NX_Q16553

  • Chr Location
    8q24.3; chr8:143018485-143022410 (+)  GRCh38.p2
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    13
  • Chemically induced (other)
    3
  • Gene trapped
    4
  • Radiation induced
    2
  • Targeted
    4
  • Genomic Mutations
    5 involving Ly6e
  • Incidental Mutations
    Mutagenetix , APF
Mice homozygous for disruptions in this gene die as embryos as a result of heart defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    85
  • Tissues
    8
  • cDNA Data
    889
  • Literature Summary
    7
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000045205 VEGA Gene Model | MGI Sequence Detail 4853 C57BL/6J ±  kb
transcript OTTMUST00000118764 VEGA | MGI Sequence Detail 2068 Not Applicable  
polypeptide OTTMUSP00000066258 VEGA | MGI Sequence Detail 136 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    52 from dbSNP Build 142
  • PCR
    1
  • RFLP
    1
Protein
Information
less
  • UniProt
    9 Sequences
  • Protein Ontology
    PR:000009989 lymphocyte antigen 6E
  • InterPro Domains
    IPR016054 Ly-6 antigen/uPA receptor-like
Molecular
Reagents
less
  • All nucleic 893
    Genomic 1
    cDNA 891
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-15264, MGD-MRK-35109
References
more
  • Summaries
    All 40
    Developmental Gene Expression 7
    Diseases 1
    Gene Ontology 3
    Phenotypes 27
  • Earliest
    J:16061 MacNeil I, et al., Isolation of a cDNA encoding thymic shared antigen-1. A new member of the Ly6 family with a possible role in T cell development. J Immunol. 1993 Dec 15;151(12):6913-23
  • Latest
    J:228795 Tunster SJ, et al., The imprinted Phlda2 gene modulates a major endocrine compartment of the placenta to regulate placental demands for maternal resources. Dev Biol. 2016 Jan 1;409(1):251-60
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support. 		last database update
09/20/2016
MGI 6.05 		The Jackson Laboratory