Ly6e MGI Mouse Gene Detail - MGI:106651 - lymphocyte antigen 6 complex, locus E

Ly6e Gene Detail

Symbol

Ly6e
Name

lymphocyte antigen 6 complex, locus E
Synonyms

9804, Ly67, RIG-E, Sca-2, Tsa1, TSA-1

Feature Type

protein coding gene
IDs

MGI:106651
NCBI Gene: 17069
Member of

Ly6 cluster
Gene Overview

MyGene.info: LY6E
Alliance

gene page

Sequence Map

Chr15:74955051-74959903 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

4853 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 34.29 cM
Mapping Data

7 experiments

Human Ortholog

LY6E, lymphocyte antigen 6 family member E

Vertebrate Orthologs

10

Human Ortholog

LY6E, lymphocyte antigen 6 family member E
Orthology source: HomoloGene, HGNC
Synonyms

RIGE, RIG-E, SCA2, SCA-2, TSA-1
Links

HGNC:6727

NCBI Gene ID: 4061

neXtProt AC: NX_Q16553

UniProt: Q16553
Chr Location

8q24.3; chr8:143018485-143022410 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 56411
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;3 chicken;1 macaque, rhesus
HCOP

human homology predictions: LY6E
Protein SuperFamily

Ly-6-like protein
Gene Tree

Ly6e

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References

1 with disease annotations

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Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
27 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

3
Gene trapped

4
Radiation induced

2
Targeted

4
Genomic Mutations

5 involving Ly6e
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

12 strains or lines available

Mice homozygous for disruptions in this gene die as embryos as a result of heart defects.

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All GO Annotations

12
GO References

3

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

85
Tissues

8
cDNA Data

889
Literature Summary

8

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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Ly6e interacts with 171 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

96
RefSeq

12
UniProt

9
CCDS

CCDS27538.1
UniGene

788

			Length	Strain/Species	Flank
genomic	OTTMUSG00000045205	VEGA Gene Model \| MGI Sequence Detail	4853	C57BL/6J	± kb
transcript	OTTMUST00000118764	VEGA \| MGI Sequence Detail	2068	Not Applicable
polypeptide	OTTMUSP00000066258	VEGA \| MGI Sequence Detail	136	Not Applicable

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SNPs within 2kb

52 from dbSNP Build 142

PCR

1
RFLP

1

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UniProt

9 Sequences
InterPro Domains

IPR016054 Ly-6 antigen/uPA receptor-like

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All nucleic 893

Genomic 1

cDNA 891

Primer pair 1

Microarray probesets 3

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MGD-MRK-15264, MGD-MRK-35109

Summaries

All 65

Developmental Gene Expression 8

Diseases 1

Gene Ontology 3

Phenotypes 27
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:253345 Bacquin A, et al., A Cell Fusion-Based Screening Method Identifies Glycosylphosphatidylinositol-Anchored Protein Ly6e as the Receptor for Mouse Endogenous Retroviral Envelope Syncytin-A. J Virol. 2017 Sep 15;91(18):None

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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