Ly6e
Gene Detail

Symbol

Name
ID
Member of

Ly6e
lymphocyte antigen 6 complex, locus E
MGI:106651
Ly6 cluster

Synonyms

9804, Ly67, RIG-E, Sca-2, Tsa1, TSA-1

Feature Type

protein coding gene

Genetic Map

Chromosome 15
34.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr15:74955051-74959903 bp, + strand From VEGA annotation of GRCm38   4853 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:56411  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 3 chicken

Protein SuperFamily: Ly-6-like protein
Gene Tree: Ly6e

Human
homologs

Human Homolog		LY6E, lymphocyte antigen 6 complex, locus E
NCBI Gene ID		4061
neXtProt AC		NX_Q16553
Human Synonyms		RIGE, RIG-E, SCA2, SCA-2, TSA-1
Human Chr (Location)		8q24.3; chr8:143018485-143022410 (+)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(9) : Gene trapped(4) Radiation induced(1) Targeted(4)
Genomic Mutations involving Ly6e (1)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for disruptions in this gene die as embryos as a result of heart defects.

 
Phenotype Images(2)

Interactions

Ly6e interacts with 172 markers (Mir1a-1, Mir1a-2, Mir1b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (10 annotations)

Process	adrenal gland development, epinephrine secretion, ...
Component	anchored component of membrane, cell, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)

Data Summary: Results (85)    Tissues (8)    Images (23)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	85

cDNA source data(889)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(893) Genomic(1) cDNA(891) Primer pair(1)
Microarray probesets(3)

Other database
links

VEGA Gene Model	OTTMUSG00000045205 (Evidence)
Ensembl Gene Model	ENSMUSG00000022587 (Evidence)
Entrez Gene	17069 (Evidence)
UniGene	788
DFCI	TC1716985, TC1600794, TC1573829
DoTS	DT.97362492, DT.50316237, DT.94309309, DT.94283009, DT.94282970
NIA Mouse Gene Index	U016341
Consensus CDS Project	CCDS27538.1
International Mouse Knockout Project Status	Ly6e

Sequences

Length	Strain/Species
genomic	OTTMUSG00000045205	VEGA Gene Model | MGI Sequence Detail	4853	C57BL/6J
transcript	OTTMUST00000118765	VEGA | MGI Sequence Detail	1122	Not Applicable
polypeptide	OTTMUSP00000066259	VEGA | MGI Sequence Detail	136	Not Applicable

All sequences(105) RefSeq(12) UniProt(9)

Polymorphisms

All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(52 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR001526	CD59 antigen
InterPro	IPR016054	Ly-6 antigen / uPA receptor -like
Protein Ontology	PR:000009989	lymphocyte antigen 6E

References

(Earliest) J:16061 MacNeil I, et al., Isolation of a cDNA encoding thymic shared antigen-1. A new member of the Ly6 family with a possible role in T cell development. J Immunol. 1993 Dec 15;151(12):6913-23
(Latest) J:200767 Hughes M, et al., Ly6e expression is restricted to syncytiotrophoblast cells of the mouse placenta. Placenta. 2013 Sep;34(9):831-5
All references(42)

Other
accession IDs

MGD-MRK-15264, MGD-MRK-35109