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Ly6e
Gene Detail
 Symbol
Name
ID
Ly6e
lymphocyte antigen 6 complex, locus E
MGI:106651
Synonyms 9804, Ly67, RIG-E, Sca-2, Tsa1, TSA-1
Feature Type protein coding gene
Genetic Map
Chromosome 15
34.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr15:74955051-74959905 bp, + strand
From NCBI annotation of GRCm38

  4855 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56411  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 3 chicken

Protein SuperFamily: Ly-6-like protein
Gene Tree: Ly6e

Human
homologs
Human Homolog LY6E, lymphocyte antigen 6 complex, locus E
NCBI Gene ID 4061
neXtProt AC  NX_Q16553
Human Synonyms  RIGE, RIG-E, SCA2, SCA-2, TSA-1
Human Chr (Location)  8q24.3; chr8:143018485-143022410 (+)  GRCh38
Alleles
and
phenotypes
All alleles(8) : Gene trapped(4) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene die as embryos as a result of heart defects.
 
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process adrenal gland development, epinephrine secretion, ...
Component anchored component of membrane, cell, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (85)    Tissues (8)    Images (23)
Theiler Stages: 17, 22, 23
Assay TypeResults
RNA in situ 85
cDNA source data(889)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(893) Genomic(1) cDNA(891) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000022587 (Evidence)
Entrez Gene17069 (Evidence)
UniGene788
DFCITC1573829, TC1600794, TC1716985
DoTSDT.50316237, DT.94282970, DT.94283009, DT.94309309, DT.97362492
NIA Mouse Gene IndexU016341
Consensus CDS ProjectCCDS27538.1
International Mouse Knockout Project StatusLy6e
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 17069 NCBI Gene Model | MGI Sequence Detail 4855 C57BL/6J ±  kb
transcript NM_001164036 RefSeq | MGI Sequence Detail 2281 C57BL/6 
polypeptide Q64253 UniProt | EBI | MGI Sequence Detail 130 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(12) UniProt(4)
Polymorphisms All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(52 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001526 CD59 antigen
InterPro IPR016054 Ly-6 antigen / uPA receptor -like
Protein Ontology PR:000009989 lymphocyte antigen 6E
Graphical View of Protein Domain Structure
References (Earliest) J:16061 MacNeil I, et al., Isolation of a cDNA encoding thymic shared antigen-1. A new member of the Ly6 family with a possible role in T cell development. J Immunol. 1993 Dec 15;151(12):6913-23
(Latest) J:178605 Stier MT, et al., Polymorphisms in Ly6 genes in Msq1 encoding susceptibility to mouse adenovirus type 1. Mamm Genome. 2011 Nov 20;
All references(40)
Other
accession IDs
MGD-MRK-15264, MGD-MRK-35109

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory