Ly6e
Gene Detail

Symbol Name ID

Ly6e lymphocyte antigen 6 complex, locus E MGI:106651

Synonyms

9804, Ly67, RIG-E, Sca-2, Tsa1, TSA-1

Feature Type

protein coding gene

Genetic Map

Chromosome 15

34.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr15:74955051-74959905 bp, + strand From NCBI annotation of GRCm38   4855 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:56411  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 3 chicken

Protein SuperFamily: Ly-6-like protein
Gene Tree: Ly6e

Human homologs

Human Homolog		LY6E, lymphocyte antigen 6 complex, locus E
NCBI Gene ID		4061
neXtProt AC		NX_Q16553
Human Synonyms		RIGE, RIG-E, SCA2, SCA-2, TSA-1
Human Chr (Location)		8q24.3; chr8:143018485-143022410 (+)  GRCh38

Alleles and phenotypes

All alleles(8) : Gene trapped(4) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for disruptions in this gene die as embryos as a result of heart defects.

 

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	adrenal gland development, epinephrine secretion, ...
Component	anchored component of membrane, cell, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)

Data Summary: Results (85)    Tissues (8)    Images (23)
Theiler Stages: 17, 22, 23

Assay Type	Results
RNA in situ	85

cDNA source data(889)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(893) Genomic(1) cDNA(891) Primer pair(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000022587 (Evidence)
Entrez Gene	17069 (Evidence)
UniGene	788
DFCI	TC1573829, TC1600794, TC1716985
DoTS	DT.50316237, DT.94282970, DT.94283009, DT.94309309, DT.97362492
NIA Mouse Gene Index	U016341
Consensus CDS Project	CCDS27538.1
International Mouse Knockout Project Status	Ly6e

Sequences

Length	Strain/Species
genomic	17069	NCBI Gene Model | MGI Sequence Detail	4855	C57BL/6J
transcript	NM_001164036	RefSeq | MGI Sequence Detail	2281	C57BL/6
polypeptide	Q64253	UniProt | EBI | MGI Sequence Detail	130	Not Applicable

All sequences(49) RefSeq(12) UniProt(4)

Polymorphisms

All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(52 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR001526	CD59 antigen
InterPro	IPR016054	Ly-6 antigen / uPA receptor -like
Protein Ontology	PR:000009989	lymphocyte antigen 6E

Graphical View of Protein Domain Structure

References

(Earliest) J:16061 MacNeil I, et al., Isolation of a cDNA encoding thymic shared antigen-1. A new member of the Ly6 family with a possible role in T cell development. J Immunol. 1993 Dec 15;151(12):6913-23
(Latest) J:178605 Stier MT, et al., Polymorphisms in Ly6 genes in Msq1 encoding susceptibility to mouse adenovirus type 1. Mamm Genome. 2011 Nov 20;
All references(40)

Other accession IDs

MGD-MRK-15264, MGD-MRK-35109