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Ly6e
Gene Detail
Symbol

Name
ID
Member of
Ly6e
lymphocyte antigen 6 complex, locus E
MGI:106651
Ly6 cluster
Synonyms
9804, Ly67, RIG-E, Sca-2, Tsa1, TSA-1
Feature Type
protein coding gene
Genetic Map
Chromosome 15
34.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr15:74955051-74959903 bp, + strand
From VEGA annotation of GRCm38

  4853 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56411  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 3 chicken

Protein SuperFamily: Ly-6-like protein
Gene Tree: Ly6e

Human
homologs
Human Homolog LY6E, lymphocyte antigen 6 complex, locus E
NCBI Gene ID 4061
neXtProt AC  NX_Q16553
Human Synonyms  RIGE, RIG-E, SCA2, SCA-2, TSA-1
Human Chr (Location)  8q24.3; chr8:143018485-143022410 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(4) Radiation induced(1) Targeted(4)
Genomic Mutations involving Ly6e (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene die as embryos as a result of heart defects.
 
Interactions
Ly6e interacts with 172 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process adrenal gland development, epinephrine secretion, ...
Component anchored component of membrane, cell, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (85)    Tissues (8)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 85
cDNA source data(889)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(893) Genomic(1) cDNA(891) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000045205 (Evidence)
Ensembl Gene ModelENSMUSG00000022587 (Evidence)
Entrez Gene17069 (Evidence)
UniGene788
DFCITC1716985, TC1600794, TC1573829
DoTSDT.94309309, DT.94283009, DT.50316237, DT.94282970, DT.97362492
NIA Mouse Gene IndexU016341
Consensus CDS ProjectCCDS27538.1
International Mouse Knockout Project StatusLy6e
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000045205 VEGA Gene Model | MGI Sequence Detail 4853 C57BL/6J ±  kb
transcript OTTMUST00000118782 VEGA | MGI Sequence Detail 735 Not Applicable 
polypeptide OTTMUSP00000066264 VEGA | MGI Sequence Detail 136 Not Applicable 

For the selected sequences
All sequences(83) RefSeq(12) UniProt(12)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(52 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001526 CD59 antigen
InterPro IPR016054 Ly-6 antigen / uPA receptor -like
Protein Ontology PR:000009989 lymphocyte antigen 6E
References
(Earliest) J:16061 MacNeil I, et al., Isolation of a cDNA encoding thymic shared antigen-1. A new member of the Ly6 family with a possible role in T cell development. J Immunol. 1993 Dec 15;151(12):6913-23
(Latest) J:200767 Hughes M, et al., Ly6e expression is restricted to syncytiotrophoblast cells of the mouse placenta. Placenta. 2013 Sep;34(9):831-5
All references(42)
Other
accession IDs
MGD-MRK-15264, MGD-MRK-35109

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory