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Enpep Gene Detail
Summary
  • Symbol
    Enpep
  • Name
    glutamyl aminopeptidase
  • Synonyms
    6030431M22Rik, aminopeptidase-A, APA, Bp-1/6C3, Ly51, Ly-51
  • Feature Type
    protein coding gene
  • IDs
    MGI:106645
    NCBI Gene: 13809
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:129062824-129126369 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 3, 57.92 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    526 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106645
protein coding gene Chr3:129062824-129126398 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027869
protein coding gene Chr3:131908131-131977627 (-)
A/J MGP_AJ_G0027827
protein coding gene Chr3:127334075-127397923 (-)
AKR/J MGP_AKRJ_G0027792
protein coding gene Chr3:130626937-130692196 (-)
BALB/cJ MGP_BALBcJ_G0027840
protein coding gene Chr3:127175852-127239217 (-)
C3H/HeJ MGP_C3HHeJ_G0027569
protein coding gene Chr3:131019195-131087850 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028284
protein coding gene Chr3:136635538-136713134 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025622
protein coding gene Chr3:122867470-122933013 (-)
CAST/EiJ MGP_CASTEiJ_G0027026
protein coding gene Chr3:130662267-130734533 (-)
CBA/J MGP_CBAJ_G0027545
protein coding gene Chr3:141229711-141299736 (-)
DBA/2J MGP_DBA2J_G0027686
protein coding gene Chr3:126527925-126592435 (-)
FVB/NJ MGP_FVBNJ_G0027653
protein coding gene Chr3:124104450-124169685 (-)
LP/J MGP_LPJ_G0027795
protein coding gene Chr3:133422392-133491209 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027684
protein coding gene Chr3:149199561-149268700 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028341
protein coding gene Chr3:130289866-130359102 (-)
PWK/PhJ MGP_PWKPhJ_G0026750
protein coding gene Chr3:126256252-126320267 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026575
protein coding gene Chr3:128351237-128419467 (-)
WSB/EiJ MGP_WSBEiJ_G0027105
protein coding gene Chr3:130999408-131066706 (-)



Homology
more
  • Human Ortholog
    ENPEP, glutamyl aminopeptidase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ENPEP, glutamyl aminopeptidase
  • Synonyms
    APA, CD249, gp160
  • Links
    NCBI Gene ID: 2028
    neXtProt AC: NX_Q07075
    UniProt: Q07075

  • Chr Location
    4q25; chr4:110365733-110565285 (+)  GRCh38

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation are viable, fertile and morphologically unaffected with normal B and T cell development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000028024 Ensembl Gene Model | MGI Sequence Detail 63546 C57BL/6J ±  kb
transcript ENSMUST00000029658 Ensembl | MGI Sequence Detail 4181 Not Applicable  
polypeptide ENSMUSP00000029658 Ensembl | MGI Sequence Detail 945 Not Applicable  
For the selected sequence
Protein
Information
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Molecular
Reagents
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  • All nucleic 98
    Genomic 11
    cDNA 85
    Primer pair 1
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-11994, MGD-MRK-12038, MGD-MRK-1610, MGD-MRK-35102, MGI:2443313
References
more
  • Summaries
    All 74
    Developmental Gene Expression 23
    Diseases 1
    Gene Ontology 8
    Phenotypes 18
  • Earliest
    J:10285 Wu Q, et al., Molecular cloning of the murine BP-1/6C3 antigen: a member of the zinc-dependent metallopeptidase family. Proc Natl Acad Sci U S A. 1990 Feb;87(3):993-7
  • Latest
    J:295193 Mace C, et al., The zinc fingers and homeoboxes 2 protein ZHX2 and its interacting proteins regulate upstream pathways in podocyte diseases. Kidney Int. 2020 Apr;97(4):753-764

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory