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Enpep
Gene Detail
 Symbol
Name
ID
Enpep
glutamyl aminopeptidase
MGI:106645
Synonyms 6030431M22Rik, aminopeptidase-A, APA, Bp-1/6C3, Ly51, Ly-51
Feature Type protein coding gene
Genetic Map
Chromosome 3
57.92 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr3:129269175-129332720 bp, - strand
From VEGA annotation of GRCm38

  63546 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68216  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Enpep

Human
homologs
Human Homolog ENPEP, glutamyl aminopeptidase (aminopeptidase A)
NCBI Gene ID 2028
neXtProt AC  NX_Q07075
Human Synonyms  APA, CD249, gp160
Human Chr (Location)  4q25; chr4:110476073-110563337 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted null mutation are viable, fertile and morphologically unaffected with normal B and T cell development.
 
Interactions
Enpep interacts with 221 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process angiogenesis, cell migration, ...
Component apical part of cell, apical plasma membrane, ...
Function aminopeptidase activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (15 records)
Data Summary: Results (107)    Tissues (64)    Images (28)
Theiler Stages: 17, 21, 23, 28
Assay TypeResults
Immunohistochemistry 2
RNA in situ 105
cDNA source data(84)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(95) Genomic(11) cDNA(84)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000036814 (Evidence)
Ensembl Gene ModelENSMUSG00000028024 (Evidence)
Entrez Gene13809 (Evidence)
UniGene1193
DFCITC1577277, TC1592578, TC1629715
DoTSDT.101215641, DT.491993, DT.91331828
NIA Mouse Gene IndexU024638
EC3.4.11.7
Consensus CDS ProjectCCDS17831.1
International Mouse Knockout Project StatusEnpep
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036814 VEGA Gene Model | MGI Sequence Detail 63546 C57BL/6J ±  kb
transcript OTTMUST00000094495 VEGA | MGI Sequence Detail 4181 Not Applicable 
polypeptide OTTMUSP00000052573 VEGA | MGI Sequence Detail 945 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(2) UniProt(6)
Polymorphisms RFLP(1) : SNPs within 2kb(536 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024571 Domain of unknown function DUF3358
InterPro IPR001930 Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase
InterPro IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal
Protein Ontology PR:000002039 glutamyl aminopeptidase
References (Earliest) J:10285 Wu Q, et al., Molecular cloning of the murine BP-1/6C3 antigen: a member of the zinc-dependent metallopeptidase family. Proc Natl Acad Sci U S A. 1990 Feb;87(3):993-7
(Latest) J:198125 Rajakumari S, et al., EBF2 determines and maintains brown adipocyte identity. Cell Metab. 2013 Apr 2;17(4):562-74
All references(56)
Other
accession IDs
MGD-MRK-11994, MGD-MRK-12038, MGD-MRK-1610, MGD-MRK-35102, MGI:2443313

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory