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Efna3 Gene Detail
Summary
  • Symbol
    Efna3
  • Name
    ephrin A3
  • Synonyms
    EFL-2, Ehk1-L, Epl3, LERK-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:106644
    NCBI Gene: 13638
  • Gene Overview
    MyGene.info: EFNA3
Location & Maps
more
  • Sequence Map
    Chr3:89313899-89322965 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9067 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 39.06 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    EFNA3, ephrin A3
  • Vertebrate Orthologs
    7
  • Human Ortholog
    EFNA3, ephrin A3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    EFL2, Ehk1-L, EPLG3, LERK3
  • Links
    NCBI Gene ID: 1944
    neXtProt AC: NX_P52797

  • Chr Location
    1q21-q22; chr1:155078872-155087538 (+)  GRCh38.p2

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 3 alleles in 3 genetic backgrounds
    18 phenotypes from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    4
  • Transgenic
    1
  • Genomic Mutations
    2 involving Efna3
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit disorganised and elongated dendritic spine of CA1 pyramidal neuron and reduced hippocampal-dependent learning.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028865 VEGA Gene Model | MGI Sequence Detail 9067 C57BL/6J ±  kb
transcript OTTMUST00000071486 VEGA | MGI Sequence Detail 2363 Not Applicable  
polypeptide OTTMUSP00000036634 VEGA | MGI Sequence Detail 230 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    6 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 17
    cDNA 13
    Primer pair 4

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-35101, MGI:2139989
References
more
  • Summaries
    All 79
    Developmental Gene Expression 34
    Diseases 1
    Gene Ontology 6
    Phenotypes 23
  • Earliest
    J:32841 Cerretti DP, et al., The genes encoding the eph-related receptor tyrosine kinase ligands LERK-1 (EPLG1, Epl1), LERK-3 (EPLG3, Epl3), and LERK-4 (EPLG4, Epl4) are clustered on human chromosome 1 and mouse chromosome 3. Genomics. 1996 Apr 15;33(2):277-82
  • Latest
    J:231672 Xavier GM, et al., Ephrin Ligands and Eph Receptors Show Regionally Restricted Expression in the Developing Palate and Tongue. Front Physiol. 2016;7:60

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory