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Efna3
Gene Detail
 Symbol
Name
ID
Efna3
ephrin A3
MGI:106644
Synonyms EFL-2, Ehk1-L, Epl3, LERK-3
Feature Type protein coding gene
Genetic Map
Chromosome 3
39.06 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr3:89313899-89322965 bp, - strand
From VEGA annotation of GRCm38

  9067 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3635  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: Ephrin-A
Gene Tree: Efna3

Human
homologs
Human Homolog EFNA3, ephrin-A3
NCBI Gene ID 1944
neXtProt AC  NX_P52797
Human Synonyms  EFL2, Ehk1-L, EPLG3, LERK3
Human Chr (Location)  1q21-q22; chr1:155078872-155087538 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit disorganised and elongated dendritic spine of CA1 pyramidal neuron and reduced hippocampal-dependent learning.
 
Interactions
Efna3 interacts with 214 markers (Mir1a-1, Mir1a-2, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process axon guidance, ephrin receptor signaling pathway, ...
Component anchored component of membrane, membrane, ...
Function ephrin receptor binding
External Resources: FuncBase
Expression
Literature Summary: (31 records)
Data Summary: Results (235)    Tissues (187)    Images (55)
Theiler Stages: 4, 5, 6, 7, 8, 10, 11, 12, 13, 15, 17, 19, 20, 22, 23, 24, 28
Assay TypeResults
Immunohistochemistry 15
RNA in situ 206
RT-PCR 14
cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(17) cDNA(13) Primer pair(4)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000028865 (Evidence)
Ensembl Gene ModelENSMUSG00000028039 (Evidence)
Entrez Gene13638 (Evidence)
DFCITC1641740, TC1642436, TC1645553
DoTSDT.40143729
Consensus CDS ProjectCCDS38488.1
International Mouse Knockout Project StatusEfna3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028865 VEGA Gene Model | MGI Sequence Detail 9067 C57BL/6J ±  kb
transcript OTTMUST00000071486 VEGA | MGI Sequence Detail 2363 Not Applicable 
polypeptide OTTMUSP00000036634 VEGA | MGI Sequence Detail 230 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(7) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(7 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008972 Cupredoxin
InterPro IPR001799 Ephrin
InterPro IPR019765 Ephrin, conserved site
Protein Ontology PR:000006918 ephrin-A3
References (Earliest) J:32841 Cerretti DP, et al., The genes encoding the eph-related receptor tyrosine kinase ligands LERK-1 (EPLG1, Epl1), LERK-3 (EPLG3, Epl3), and LERK-4 (EPLG4, Epl4) are clustered on human chromosome 1 and mouse chromosome 3. Genomics. 1996 Apr 15;33(2):277-82
(Latest) J:204427 Brennaman LH, et al., Polysialylated NCAM and ephrinA/EphA regulate synaptic development of GABAergic interneurons in prefrontal cortex. Cereb Cortex. 2013 Jan;23(1):162-77
All references(78)
Other
accession IDs
MGD-MRK-35101, MGI:2139989

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory