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Efna3
Gene Detail
Symbol

Name
ID
Efna3
ephrin A3
MGI:106644
Synonyms
EFL-2, Ehk1-L, Epl3, LERK-3
Feature Type
protein coding gene
Genetic Map
Chromosome 3
39.06 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr3:89313899-89322965 bp, - strand
From VEGA annotation of GRCm38

  9067 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3635  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: EFNA3
Protein SuperFamily: Ephrin-A
Gene Tree: Efna3

Human
homologs
EFNA3, ephrin-A3
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 1944
neXtProt AC: NX_P52797

Human Synonyms: EFL2, Ehk1-L, EPLG3, LERK3

Human Chr (Location): 1q21-q22; chr1:155078872-155087538 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit disorganised and elongated dendritic spine of CA1 pyramidal neuron and reduced hippocampal-dependent learning.
 
Interactions
Efna3 interacts with 213 markers (Mir1a-1, Mir1a-2, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process axon guidance, ephrin receptor signaling pathway, ...
Component anchored component of membrane, membrane, ...
Function ephrin receptor binding
External Resources: FuncBase
Expression
Literature Summary: (32 records)
Data Summary: Results (235)    Tissues (187)    Images (55)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 15
RNA in situ 206
RT-PCR 14
cDNA source data(11)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase efna3 ; ZFIN efna3b    NEW 
Molecular
reagents
All nucleic(17) cDNA(13) Primer pair(4)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000028865 (Evidence)
Ensembl Gene Model ENSMUSG00000028039 (Evidence)
Entrez Gene 13638 (Evidence)
DFCI TC1642436, TC1641740, TC1645553
DoTS DT.40143729
Consensus CDS Project CCDS38488.1
International Mouse Phenotyping Consortium Status Efna3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028865 VEGA Gene Model | MGI Sequence Detail 9067 C57BL/6J ±  kb
transcript OTTMUST00000071486 VEGA | MGI Sequence Detail 2363 Not Applicable 
polypeptide OTTMUSP00000036634 VEGA | MGI Sequence Detail 230 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(5) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(7 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008972 Cupredoxin
InterPro IPR001799 Ephrin
InterPro IPR019765 Ephrin, conserved site
Protein Ontology PR:000006918 ephrin-A3
References
(Earliest) J:32841 Cerretti DP, et al., The genes encoding the eph-related receptor tyrosine kinase ligands LERK-1 (EPLG1, Epl1), LERK-3 (EPLG3, Epl3), and LERK-4 (EPLG4, Epl4) are clustered on human chromosome 1 and mouse chromosome 3. Genomics. 1996 Apr 15;33(2):277-82
(Latest) J:214811 Weiss AC, et al., Nephric duct insertion requires EphA4/EphA7 signaling from the pericloacal mesenchyme. Development. 2014 Sep;141(17):3420-30
All references(78)
Other
accession IDs
MGD-MRK-35101, MGI:2139989

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory