Slc30a2 MGI Mouse Gene Detail - MGI:106637 - solute carrier family 30 (zinc transporter), member 2

Symbol

Slc30a2
Name

solute carrier family 30 (zinc transporter), member 2
Synonyms

Znt2

Feature Type

protein coding gene
IDs

MGI:106637
NCBI Gene: 230810
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr4:134343181-134354484 bp, + strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 66.61 cM
Mapping Data

3 experiments

SNPs within 2kb

177 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_106637	protein coding gene	Chr4:134343046-134354484 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028924	protein coding gene	Chr4:136691026-136708680 (+)
A/J	MGP_AJ_G0028883	protein coding gene	Chr4:130943621-130953231 (+)
AKR/J	MGP_AKRJ_G0028835	protein coding gene	Chr4:134694928-134706507 (+)
BALB/cJ	MGP_BALBcJ_G0028907	protein coding gene	Chr4:131586272-131596029 (+)
C3H/HeJ	MGP_C3HHeJ_G0028621	protein coding gene	Chr4:134933421-134943535 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029348	protein coding gene	Chr4:141628710-141640007 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026619	protein coding gene	Chr4:124001195-124012979 (+)
CAST/EiJ	MGP_CASTEiJ_G0028053	protein coding gene	Chr4:133058498-133069768 (+)
CBA/J	MGP_CBAJ_G0028586	protein coding gene	Chr4:145349494-145359016 (+)
DBA/2J	MGP_DBA2J_G0028735	protein coding gene	Chr4:131367045-131376570 (+)
FVB/NJ	MGP_FVBNJ_G0028702	protein coding gene	Chr4:130257974-130269467 (+)
LP/J	MGP_LPJ_G0028834	protein coding gene	Chr4:136784106-136794696 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028728	protein coding gene	Chr4:149840401-149850334 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029386	protein coding gene	Chr4:135135360-135146644 (+)
PWK/PhJ	MGP_PWKPhJ_G0027773	protein coding gene	Chr4:128094073-128103734 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027599	protein coding gene	Chr4:130949628-130959914 (+)
WSB/EiJ	MGP_WSBEiJ_G0028131	protein coding gene	Chr4:135296736-135308830 (+)

Human Ortholog

SLC30A2, solute carrier family 30 member 2

Vertebrate Orthologs

10

Human Ortholog

SLC30A2, solute carrier family 30 member 2
Orthology source: HomoloGene, HGNC
Synonyms

PP12488, TNZD, ZnT-2, ZNT2
Links

HGNC:11013

NCBI Gene ID: 7780

neXtProt AC: NX_Q9BRI3

UniProt: Q9BRI3
Chr Location

1p36.11; chr1:26038022-26046138 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 40855
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: SLC30A2
Protein SuperFamily

cation efflux protein
Gene Tree

Slc30a2

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Phenotype Summary

13 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Chemically induced (other)

2
Endonuclease-mediated

2
Gene trapped

10
Radiation induced

1
Targeted

2
Genomic Mutations

4 involving Slc30a2
Incidental Mutations

APF
Find Mice (IMSR)

10 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit abnormal mammary gland development during lactation, abnormal zinc levels in the mammary gland and milk, impaired lactation and decreased litter survival.

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All GO Annotations

22
GO References

6

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

652
Tissues

3
cDNA Data

27
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slc30a2

ZFIN slc30a2

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Slc30a2 interacts with 193 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

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All Sequences

43
RefSeq

6
UniProt

4
CCDS

CCDS38915.1, CCDS89842.1
UniGene

358876

Ensembl

ENSMUSG00000028836 (Evidence)
NCBI Gene

230810

			Length	Strain/Species	Flank
genomic	ENSMUSG00000028836	Ensembl Gene Model \| MGI Sequence Detail	11304	C57BL/6J	± kb
transcript	ENSMUST00000105874	Ensembl \| MGI Sequence Detail	3153	Not Applicable
polypeptide	ENSMUSP00000101500	Ensembl \| MGI Sequence Detail	371	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000015075 zinc transporter 2

(term hierarchy)
InterPro Domains

IPR002524 Cation efflux protein

IPR036837 Cation efflux protein, cytoplasmic domain superfamily

IPR027469 Cation efflux transmembrane domain superfamily

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All nucleic 31

Genomic 1

cDNA 28

Primer pair 1

Other 1

Microarray probesets 1

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MGD-MRK-35094

Summaries

All 40

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 12
Earliest

J:32792 Palmiter RD, et al., ZnT-2, a mammalian protein that confers resistance to zinc by facilitating vesicular sequestration. EMBO J. 1996 Apr 15;15(8):1784-91
Latest

J:264255 Rivera OC, et al., ZnT2 is critical for lysosome acidification and biogenesis during mammary gland involution. Am J Physiol Regul Integr Comp Physiol. 2018 Aug 1;315(2):R323-R335

TSS for Slc30a2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr39548	Chr4:134343143-134343154 (+)	-32 bp
Tssr39549	Chr4:134343198-134343211 (+)	24 bp
Tssr39550	Chr4:134343493-134343506 (+)	319 bp
Tssr39551	Chr4:134343523-134343535 (+)	348 bp
Tssr39552	Chr4:134343598-134343608 (+)	422 bp
Tssr39553	Chr4:134343632-134343680 (+)	475 bp
Tssr39554	Chr4:134343683-134343704 (+)	513 bp
Tssr39555	Chr4:134343882-134343909 (+)	715 bp
Tssr39556	Chr4:134344002-134344024 (+)	832 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 03/24/2020 MGI 6.15