Slc30a2 Gene Detail

Summary

• Symbol
  Slc30a2
• Name
  solute carrier family 30 (zinc transporter), member 2
• Synonyms
  Znt2

• Feature Type
  protein coding gene
• IDs
  MGI:106637
  NCBI Gene: 230810
• Alliance
  gene page

Location & Maps

• Sequence Map
  Chr4:134343181-134354484 bp, + strand
• From VEGA annotation of GRCm38
  

  Mouse Genome Browser
  
  

• Download
  Sequence
    11304 bp   ±  kb flank
  
  
• Genome Browsers
  VEGA | Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 4, 66.61 cM
• Mapping Data
  3 experiments

Homology

• Human Ortholog
  SLC30A2, solute carrier family 30 member 2

• Vertebrate Orthologs
  10

• Human Ortholog
  SLC30A2, solute carrier family 30 member 2
  Orthology source: HomoloGene, HGNC
• Synonyms
  PP12488, TNZD, ZnT-2, ZNT2
• Links
  HGNC:11013

  NCBI Gene ID: 7780

  neXtProt AC: NX_Q9BRI3

  UniProt: Q9BRI3

  
  
• Chr Location
  1p36.11; chr1:26038022-26046138 (-)  GRCh38.p7

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• HomoloGene
  Vertebrate Homology Class 40855
  1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  
• HCOP
  human homology predictions: SLC30A2
• Protein SuperFamily
  cation efflux protein
• Gene Tree
  Slc30a2
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  7 phenotype references
  

• All Mutations and Alleles
  14
• Chemically induced (other)
  2
• Gene trapped
  10
• Radiation induced
  1
• Targeted
  1
• Genomic Mutations
  4 involving Slc30a2
• Incidental Mutations
  APF
• Find Mice (IMSR)
  10 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  21
• GO References
  6

• External Resources
  FuncBase

Expression

• Assay Results
  21
• Tissues
  3
• cDNA Data
  26
• Literature Summary
  1

Images

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase slc30a2
  ZFIN slc30a2

Interactions

• Slc30a2 interacts with 193 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

Sequences &
Gene Models

• All Sequences
  34
• RefSeq
  6
• UniProt
  4
• CCDS
  CCDS38915.1
• UniGene
  358876

• VEGA
  OTTMUSG00000010829 (Evidence)
• Ensembl
  ENSMUSG00000028836 (Evidence)
• NCBI Gene
  230810

Representative Sequences			Length	Strain/Species
genomic	OTTMUSG00000010829	VEGA Gene Model | MGI Sequence Detail	11304	C57BL/6J
transcript	OTTMUST00000025324	VEGA | MGI Sequence Detail	3153	Not Applicable
polypeptide	OTTMUSP00000011613	VEGA | MGI Sequence Detail	371	Not Applicable

Polymorphisms

• SNPs within 2kb
  177 from dbSNP Build 142

• RFLP
  1

Protein
Information

• UniProt
  4 Sequences
• Protein Ontology
  PR:000015075 zinc transporter 2
  (term hierarchy)
• InterPro Domains
  IPR002524 Cation efflux protein
  IPR036837 Cation efflux protein, cytoplasmic domain superfamily
  IPR027469 Cation efflux transmembrane domain superfamily

Molecular
Reagents

• All nucleic 30

  Genomic 1

  cDNA 27

  Primer pair 1

  Other 1

  
  

  Microarray probesets 1

Other
Accession IDs

MGD-MRK-35094

References

• Summaries
  All 34

  Developmental Gene Expression 1

  Gene Ontology 6

  Phenotypes 7
• Earliest
  J:32792 Palmiter RD, et al., ZnT-2, a mammalian protein that confers resistance to zinc by facilitating vesicular sequestration. EMBO J. 1996 Apr 15;15(8):1784-91
• Latest
  J:241041 Zhao Y, et al., Differential Targeting of SLC30A10/ZnT10 Heterodimers to Endolysosomal Compartments Modulates EGF-Induced MEK/ERK1/2 Activity. Traffic. 2016 Mar;17(3):267-88