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Phox2a
Gene Detail
 Symbol
Name
ID
Phox2a
paired-like homeobox 2a
MGI:106633
Synonyms Arix, Pmx2, Pmx2a
Feature Type protein coding gene
Genetic Map
Chromosome 7
54.66 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr7:101818313-101822726 bp, + strand
From VEGA annotation of GRCm38

  4414 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31296  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Phox2a

Human
homologs
Human Homolog PHOX2A, paired-like homeobox 2a
NCBI Gene ID 401
neXtProt AC  NX_O14813
Human Synonyms  ARIX, CFEOM2, FEOM2, NCAM2, PMX2A
Human Chr (Location)  11q13.2; chr11:72239077-72244176 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human PHOX2A
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(1) Targeted(7)
Incidental mutations (data from APF )
 
Homozygotes for targeted null mutations exhibit deficits in sensory and autonomic ganglia, lack of the locus coeruleus, and impaired migration of facial visceral motor axon. Mutants appear normal at birth but fail to nurse and die within 24 hours.
 
Human Diseases Modeled Using Mouse Phox2a (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Phox2a interacts with 99 markers (Mir17, Mir19a, Mir19b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process locus ceruleus development, midbrain development, ...
Component nuclear chromatin, nucleus
Function DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription, ...
External Resources: FuncBase
Expression
Literature Summary: (81 records)
Data Summary: Results (261)    Tissues (222)    Images (66)
Theiler Stages: 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 25, 28
Assay TypeResults
Immunohistochemistry 28
RNA in situ 226
Northern blot 7
cDNA source data(10)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(19) Genomic(3) cDNA(11) Other(5)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000037719 (Evidence)
Ensembl Gene ModelENSMUSG00000007946 (Evidence)
Entrez Gene11859 (Evidence)
UniGene5028
DFCITC1587102, TC1663562
Consensus CDS ProjectCCDS21514.1
International Mouse Knockout Project StatusPhox2a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037719 VEGA Gene Model | MGI Sequence Detail 4414 C57BL/6J ±  kb
transcript OTTMUST00000097413 VEGA | MGI Sequence Detail 1609 Not Applicable 
polypeptide OTTMUSP00000054636 VEGA | MGI Sequence Detail 280 Not Applicable 

For the selected sequences
All sequences(17) RefSeq(2) UniProt(1)
Polymorphisms RFLP(1) : SNPs within 2kb(14 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
Protein Ontology PR:000012671 paired mesoderm homeobox protein 2A
References (Earliest) J:15712 Valarche I, et al., The mouse homeodomain protein Phox2 regulates Ncam promoter activity in concert with Cux/CDP and is a putative determinant of neurotransmitter phenotype. Development. 1993 Nov;119(3):881-96
(Latest) J:201733 Xu Y, et al., Ontogeny of excitatory spinal neurons processing distinct somatic sensory modalities. J Neurosci. 2013 Sep 11;33(37):14738-48
All references(111)
Other
accession IDs
MGD-MRK-13533, MGD-MRK-35090, MGI:97713

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory