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Phox2a
Gene Detail
Symbol

Name
ID
Phox2a
paired-like homeobox 2a
MGI:106633
Synonyms
Arix, Pmx2, Pmx2a
Feature Type
protein coding gene
Genetic Map
Chromosome 7
54.66 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr7:101818313-101822726 bp, + strand
From VEGA annotation of GRCm38

  4414 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31296  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PHOX2A
Gene Tree: Phox2a

Human
homologs
PHOX2A, paired-like homeobox 2a
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 401
neXtProt AC: NX_O14813

Human Synonyms: ARIX, CFEOM2, FEOM2, NCAM2, PMX2A

Human Chr (Location): 11q13.2; chr11:72239077-72244176 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PHOX2A

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(1) Targeted(7)
Incidental mutations (data from APF , CvDC )
 
Homozygotes for targeted null mutations exhibit deficits in sensory and autonomic ganglia, lack of the locus coeruleus, and impaired migration of facial visceral motor axon. Mutants appear normal at birth but fail to nurse and die within 24 hours.
 
Human Diseases Modeled in Mice Using Phox2a (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Phox2a interacts with 99 markers (Mir17, Mir19a, Mir19b-1, ...)
Expression
Literature Summary: (82 records)
Data Summary: Results (296)    Tissues (238)    Images (88)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 63
RNA in situ 226
Northern blot 7
cDNA source data(10)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: ZFIN phox2a    NEW 
Molecular
reagents
All nucleic(19) Genomic(3) cDNA(11) Other(5)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000037719 (Evidence)
Ensembl Gene Model ENSMUSG00000007946 (Evidence)
Entrez Gene 11859 (Evidence)
UniGene 5028
DFCI TC1663562, TC1587102
Consensus CDS Project CCDS21514.1
International Mouse Phenotyping Consortium Status Phox2a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037719 VEGA Gene Model | MGI Sequence Detail 4414 C57BL/6J ±  kb
transcript OTTMUST00000097413 VEGA | MGI Sequence Detail 1609 Not Applicable 
polypeptide OTTMUSP00000054636 VEGA | MGI Sequence Detail 280 Not Applicable 

For the selected sequences
All sequences(17) RefSeq(2) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(14 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
Protein Ontology PR:000012671 paired mesoderm homeobox protein 2A
References
(Earliest) J:15712 Valarche I, et al., The mouse homeodomain protein Phox2 regulates Ncam promoter activity in concert with Cux/CDP and is a putative determinant of neurotransmitter phenotype. Development. 1993 Nov;119(3):881-96
(Latest) J:208841 Millen KJ, et al., Transformation of the cerebellum into more ventral brainstem fates causes cerebellar agenesis in the absence of Ptf1a function. Proc Natl Acad Sci U S A. 2014 Apr 29;111(17):E1777-86
All references(111)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-13533, MGD-MRK-35090, MGI:97713

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory