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Myo9b Gene Detail
Summary
  • Symbol
    Myo9b
  • Name
    myosin IXb
  • Feature Type
    protein coding gene
  • IDs
    MGI:106624
    NCBI Gene: 17925
  • Gene Overview
    MyGene.info: MYO9B
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:71272714-71360713 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 34.43 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    425 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106624
protein coding gene Chr8:71272619-71360713 (.)
129S1/SvImJ MGP_129S1SvImJ_G0033738
protein coding gene Chr8:71633716-71748340 (+)
A/J MGP_AJ_G0033721
protein coding gene Chr8:68734671-68827988 (+)
AKR/J MGP_AKRJ_G0033646
protein coding gene Chr8:70740172-70847901 (+)
BALB/cJ MGP_BALBcJ_G0033717
protein coding gene Chr8:68900424-68996808 (+)
C3H/HeJ MGP_C3HHeJ_G0033427
protein coding gene Chr8:71325735-71434449 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034235
protein coding gene Chr8:74399442-74491871 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031177
protein coding gene Chr8:63381774-63468479 (+)
CAST/EiJ MGP_CASTEiJ_G0032752
protein coding gene Chr8:70784233-70885489 (+)
CBA/J MGP_CBAJ_G0033405
protein coding gene Chr8:77014135-77107595 (+)
DBA/2J MGP_DBA2J_G0033559
protein coding gene Chr8:68440394-68556438 (+)
FVB/NJ MGP_FVBNJ_G0033501
protein coding gene Chr8:67535015-67636385 (+)
LP/J MGP_LPJ_G0033646
protein coding gene Chr8:71615385-71727951 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033548
protein coding gene Chr8:79587284-79692258 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034252
protein coding gene Chr8:70817239-70919883 (+)
PWK/PhJ MGP_PWKPhJ_G0032459
protein coding gene Chr8:67736280-67831276 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032296
protein coding gene Chr8:69775624-69880405 (+)
WSB/EiJ MGP_WSBEiJ_G0032867
protein coding gene Chr8:71159658-71268725 (+)



Homology
more
  • Human Ortholog
    MYO9B, myosin IXB
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MYO9B, myosin IXB
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CELIAC4, MYR5
  • Links
    NCBI Gene ID: 4650
    neXtProt AC: NX_Q13459
    UniProt: Q13459

  • Chr Location
    19p13.11; chr19:17075781-17213295 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 3058
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MYO9B
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human MYO9B associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mutants breed normal, but shows defect in macrophage motility and chemotaxis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000004677 Ensembl Gene Model | MGI Sequence Detail 88000 C57BL/6J ±  kb
transcript ENSMUST00000170242 Ensembl | MGI Sequence Detail 7297 Not Applicable  
polypeptide ENSMUSP00000129220 Ensembl | MGI Sequence Detail 2128 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 128
    cDNA 122
    Primer pair 5
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-35081
References
more
  • Summaries
    All 39
    Developmental Gene Expression 1
    Gene Ontology 7
    Phenotypes 9
  • Earliest
    J:35477 Hasson T, et al., Mapping of unconventional myosins in mouse and human. Genomics. 1996 Sep 15;36(3):431-9
  • Latest
    J:264049 Moalli F, et al., The Rho regulator Myosin IXb enables nonlymphoid tissue seeding of protective CD8(+) T cells. J Exp Med. 2018 Jul 2;215(7):1869-1890

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory