About   Help   FAQ
Myo9b Gene Detail
Summary
  • Symbol
    Myo9b
  • Name
    myosin IXb
  • Feature Type
    protein coding gene
  • IDs
    MGI:106624
    NCBI Gene: 17925
  • Gene Overview
    MyGene.info: MYO9B
Location & Maps
more
  • Sequence Map
    Chr8:71272714-71360712 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      87999 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    MYO9B, myosin IXB
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MYO9B, myosin IXB
    Orthology source: HomoloGene
  • Synonyms
    CELIAC4, MYR5
  • Links
    NCBI Gene ID: 4650
    neXtProt AC: NX_Q13459

  • Chr Location
    19p13.1; chr19:17075779-17215277 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 3058
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: MYO9B
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human MYO9B associations

Human Disease Mouse Models
       Celiac Disease, Susceptibility to, 4; CELIAC4   OMIM: 609753
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    15
  • Chemically induced (other)
    1
  • Gene trapped
    10
  • Targeted
    4
  • Genomic Mutations
    1 involving Myo9b
  • Incidental Mutations
Homozygous null mutants breed normal, but shows defect in macrophage motility and chemotaxis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000004677 Ensembl Gene Model | MGI Sequence Detail 87999 C57BL/6J ±  kb
transcript ENSMUST00000170242 Ensembl | MGI Sequence Detail 7297 Not Applicable  
polypeptide ENSMUSP00000129220 Ensembl | MGI Sequence Detail 2128 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    425 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000010872 myosin-IXb
  • InterPro Domains
    IPR000048 IQ motif, EF-hand binding site
    IPR001609 Myosin head, motor domain
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
    IPR000159 Ras-associating (RA) domain
    IPR000198 Rho GTPase-activating protein domain
    IPR008936 Rho GTPase activation protein
    IPR029071 Ubiquitin-related domain
    IPR028557 Unconventional myosin-IXb
Molecular
Reagents
less
  • All nucleic 128
    cDNA 122
    Primer pair 5
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-35081
References
more
  • Summaries
    All 35
    Developmental Gene Expression 1
    Gene Ontology 7
    Phenotypes 8
  • Earliest
    J:35477 Hasson T, et al., Mapping of unconventional myosins in mouse and human. Genomics. 1996 Sep 15;36(3):431-9
  • Latest
    J:209997 Xu Y, et al., Dendritic cell motility and T cell activation requires regulation of Rho-cofilin signaling by the Rho-GTPase activating protein myosin IXb. J Immunol. 2014 Apr 15;192(8):3559-68

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/17/2016
MGI 6.03
The Jackson Laboratory