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Myo9b
Gene Detail
 Symbol
Name
ID
Myo9b
myosin IXb
MGI:106624
Feature Type protein coding gene
Genetic Map
Chromosome 8
34.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr8:71272714-71360712 bp, + strand
From NCBI annotation of GRCm38

  87999 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3058  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Myo9b

Human
homologs
Human Homolog MYO9B, myosin IXB
NCBI Gene ID 4650
neXtProt AC  NX_Q13459
Human Synonyms  CELIAC4, MYR5
Human Chr (Location)  19p13.1; chr19:17075781-17213295 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human MYO9B
Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(10) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants breed normal, but shows defect in macrophage motility and chemotaxis.
 
Interactions
Myo9b interacts with 223 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (60 annotations)
Process actin-myosin filament sliding, ATP catabolic process, ...
Component actin filament, cell cortex, ...
Function actin binding, actin-dependent ATPase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (14)    Tissues (7)   
Theiler Stages: 17, 21, 28
Assay TypeResults
RT-PCR 14
cDNA source data(121)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(128) cDNA(122) Primer pair(5) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000004677 (Evidence)
Entrez Gene17925 (Evidence)
UniGene33779
DFCITC1576156, TC1602603, TC1603476, TC1715622
DoTSDT.101387629, DT.101710558, DT.110890442, DT.489345, DT.97349144
Consensus CDS ProjectCCDS40379.1, CCDS52580.1, CCDS52581.1
International Mouse Knockout Project StatusMyo9b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 17925 NCBI Gene Model | MGI Sequence Detail 87999 C57BL/6J ±  kb
transcript NM_001142322 RefSeq | MGI Sequence Detail 7296 C57BL/6 
polypeptide Q9QY06 UniProt | EBI | MGI Sequence Detail 2114 Not Applicable 

For the selected sequences
All sequences(95) RefSeq(55) UniProt(8)
Polymorphisms RFLP(2) : SNPs within 2kb(459 from dbSNP Build 137)    SNPs within 2kb including multiple locations(519)
Protein-related
information
ResourceIDDescription
InterPro IPR000048 IQ motif, EF-hand binding site
InterPro IPR001609 Myosin head, motor domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
InterPro IPR000159 Ras-association
InterPro IPR000198 Rho GTPase-activating protein domain
InterPro IPR008936 Rho GTPase activation protein
Protein Ontology PR:000010872 myosin-IXb
Graphical View of Protein Domain Structure
References (Earliest) J:35477 Hasson T, et al., Mapping of unconventional myosins in mouse and human. Genomics. 1996 Sep 15;36(3):431-9
(Latest) J:209997 Xu Y, et al., Dendritic cell motility and T cell activation requires regulation of Rho-cofilin signaling by the Rho-GTPase activating protein myosin IXb. J Immunol. 2014 Apr 15;192(8):3559-68
All references(39)
Other
accession IDs
MGD-MRK-35081

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory