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Gpx2 Gene Detail
Summary
  • Symbol
    Gpx2
  • Name
    glutathione peroxidase 2
  • Synonyms
    GI-GPx, GPx-GI, intestinal GPx
  • Feature Type
    protein coding gene
  • IDs
    MGI:106609
    NCBI Gene: 14776
Location & Maps
more
  • Sequence Map
    Chr12:76792335-76795554 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3220 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    GPX2, glutathione peroxidase 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GPX2, glutathione peroxidase 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    GI-GPx, GPRP, GPRP-2, GPx-2, GPx-GI, GSHPx-2, GSHPX-GI
  • Links
    NCBI Gene ID: 2877
    neXtProt AC: NX_P18283

  • Chr Location
    14q24.1; chr14:64939152-64942905 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 2 alleles in 1 genetic background
    15 phenotypes from multigenic genotypes
    21 phenotype references
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Targeted
    2
  • Genomic Mutations
    1 involving Gpx2
  • Incidental Mutations
Homozygotes for a targeted null allele appear normal, but double knockouts with Gpx1 exhibit symptoms of inflammatory bowel disease, including perianal ulceration, growth retardation, and hypothermia, a condition that is sometimes fatal.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 14776 NCBI Gene Model | MGI Sequence Detail 3220 C57BL/6J ±  kb
transcript NM_030677 RefSeq | MGI Sequence Detail 1071 C57BL/6  
polypeptide Q9JHC0 UniProt | EBI | MGI Sequence Detail 190 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    23 from dbSNP Build 137
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 13
    Genomic 2
    cDNA 11

    Microarray probesets 2
Other
Accession IDs
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MGD-MRK-35066
References
more
  • Summaries
    All 51
    Developmental Gene Expression 10
    Gene Ontology 8
    Phenotypes 21
  • Earliest
    J:32889 Chu FF, et al., The mouse glutathione peroxidase Gpx2 gene maps to chromosome 12; its pseudogene Gpx2-ps maps to chromosome 7. Genomics. 1996 May 1;33(3):516-8
  • Latest
    J:211847 Esworthy RS, et al., Nox1 causes ileocolitis in mice deficient in glutathione peroxidase-1 and -2. Free Radic Biol Med. 2014 Mar;68:315-25

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory