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Gpx2
Gene Detail
Symbol

Name
ID
Gpx2
glutathione peroxidase 2
MGI:106609
Synonyms
GI-GPx, GPx-GI, intestinal GPx
Feature Type
protein coding gene
Genetic Map
Chromosome 12
33.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr12:76792335-76795554 bp, - strand
From NCBI annotation of GRCm38

  3220 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20479  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: GPX2
Protein SuperFamily: glutathione peroxidase
Gene Tree: Gpx2

Human
homologs
GPX2, glutathione peroxidase 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 2877
neXtProt AC: NX_P18283

Human Synonyms: GI-GPx, GPRP, GPRP-2, GPx-2, GPx-GI, GSHPx-2, GSHPX-GI

Human Chr (Location): 14q24.1; chr14:64939152-64942905 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null allele appear normal, but double knockouts with Gpx1 exhibit symptoms of inflammatory bowel disease, including perianal ulceration, growth retardation, and hypothermia, a condition that is sometimes fatal.
 
Interactions
Gpx2 interacts with 44 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (10 records)
Data Summary: Results (156)    Tissues (107)    Images (28)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 156
cDNA source data(9)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase gpx2    NEW 
Molecular
reagents
All nucleic(13) Genomic(2) cDNA(11)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000042808 (Evidence)
Entrez Gene 14776 (Evidence)
UniGene 441856
DoTS DT.101165889, DT.101322524
EC 1.11.1.9
Consensus CDS Project CCDS25996.1
International Mouse Phenotyping Consortium Status Gpx2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 14776 NCBI Gene Model | MGI Sequence Detail 3220 C57BL/6J ±  kb
transcript NM_030677 RefSeq | MGI Sequence Detail 1071 C57BL/6 
polypeptide Q9JHC0 UniProt | EBI | MGI Sequence Detail 190 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(2) UniProt(1)
Polymorphisms
RFLP(2) : SNPs within 2kb(23 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000889 Glutathione peroxidase
InterPro IPR012336 Thioredoxin-like fold
Protein Ontology PR:000008211 glutathione peroxidase 2
Graphical View of Protein Domain Structure
References
(Earliest) J:32889 Chu FF, et al., The mouse glutathione peroxidase Gpx2 gene maps to chromosome 12; its pseudogene Gpx2-ps maps to chromosome 7. Genomics. 1996 May 1;33(3):516-8
(Latest) J:211847 Esworthy RS, et al., Nox1 causes ileocolitis in mice deficient in glutathione peroxidase-1 and -2. Free Radic Biol Med. 2014 Mar;68:315-25
All references(53)
Other
accession IDs
MGD-MRK-35066

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory