Serpinb9
Gene Detail

Symbol Name ID

Serpinb9 serine (or cysteine) peptidase inhibitor, clade B, member 9 MGI:106603

Synonyms

ovalbumin, PI-9, Spi6

Feature Type

protein coding gene

Genetic Map

Chromosome 13

13.79 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr13:33003250-33017957 bp, + strand From VEGA annotation of GRCm38   14708 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37888  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: serpin
Gene Tree: Serpinb9

Human homologs

Human Homolog		SERPINB9, serpin peptidase inhibitor, clade B (ovalbumin), member 9
NCBI Gene ID		5272
neXtProt AC		NX_P50453
Human Synonyms		CAP3, CAP-3, PI9, PI-9
Human Chr (Location)		6p25; chr6:2887499-2903546 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(1) : Targeted(1)
 

Homozygous null mice show defective CTL immunity and clearance of LCMV. Following infection with LCMV or L. monocytogenes, mutant CTLs display a breakdown of cytotoxic granule integrity, increased cytoplasmic granzyme B, and reduced survival due to increased granzyme B-mediated apoptosis.

 

Gene Ontology (GO) classifications

All GO classifications: (20 annotations)

Process	acute inflammatory response to antigenic stimulus, defense response to bacterium, ...
Component	cytoplasm, cytosol, ...
Function	cysteine-type endopeptidase inhibitor activity involved in apoptotic process, protease binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (8)    Tissues (8)    Images (1)
Theiler Stages: 28

Assay Type	Results
Northern blot	8

cDNA source data(56)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(59) Genomic(2) cDNA(57)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000000696 (Evidence)
Ensembl Gene Model	ENSMUSG00000045827 (Evidence)
Entrez Gene	20723 (Evidence)
UniGene	272569
DFCI	TC1580127, TC1648366
DoTS	DT.530389
NIA Mouse Gene Index	U043324
Consensus CDS Project	CCDS26431.1
International Mouse Knockout Project Status	Serpinb9

Sequences

Length	Strain/Species
genomic	OTTMUSG00000000696	VEGA Gene Model | MGI Sequence Detail	14708	C57BL/6J
transcript	OTTMUST00000001329	VEGA | MGI Sequence Detail	3472	Not Applicable
polypeptide	OTTMUSP00000000626	VEGA | MGI Sequence Detail	374	Not Applicable

All sequences(26) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(2) : SNPs(86 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR023795	Protease inhibitor I4, serpin, conserved site
InterPro	IPR000240	Serpin B9/maspin
InterPro	IPR023796	Serpin domain
InterPro	IPR000215	Serpin family

References

(Earliest) J:26852 Sun J, et al., Gene structure, chromosomal localization, and expression of the murine homologue of human proteinase inhibitor 6 (PI-6) suggests divergence of PI-6 from the ovalbumin serpins. J Biol Chem. 1995 Jul 7;270(27):16089-96
(Latest) J:181216 Lovo E, et al., Serine protease inhibitor 6 is required to protect dendritic cells from the kiss of death. J Immunol. 2012 Feb 1;188(3):1057-63
All references(36)

Other accession IDs

MGD-MRK-35059, MGI:3035078