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Serpinb9
Gene Detail
 Symbol
Name
ID
Serpinb9
serine (or cysteine) peptidase inhibitor, clade B, member 9
MGI:106603
Synonyms ovalbumin, PI-9, Spi6
Feature Type protein coding gene
Genetic Map
Chromosome 13
13.79 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr13:33003250-33017957 bp, + strand
From VEGA annotation of GRCm38

  14708 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37888  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: serpin
Gene Tree: Serpinb9

Human
homologs
Human Homolog SERPINB9, serpin peptidase inhibitor, clade B (ovalbumin), member 9
NCBI Gene ID 5272
neXtProt AC  NX_P50453
Human Synonyms  CAP3, CAP-3, PI9, PI-9
Human Chr (Location)  6p25; chr6:2887265-2903312 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice show defective CTL immunity and clearance of LCMV. Following infection with LCMV or L. monocytogenes, mutant CTLs display a breakdown of cytotoxic granule integrity, increased cytoplasmic granzyme B, and reduced survival due to increased granzyme B-mediated apoptosis.
 
Interactions
Serpinb9 interacts with 319 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process acute inflammatory response to antigenic stimulus, defense response to bacterium, ...
Component cytoplasm, cytosol, ...
Function cysteine-type endopeptidase inhibitor activity involved in apoptotic process, protease binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (8)    Tissues (8)    Images (1)
Theiler Stages: 28
Assay TypeResults
Northern blot 8
cDNA source data(56)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(59) Genomic(2) cDNA(57)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000000696 (Evidence)
Ensembl Gene ModelENSMUSG00000045827 (Evidence)
Entrez Gene20723 (Evidence)
UniGene272569
DFCITC1580127, TC1648366
DoTSDT.530389
NIA Mouse Gene IndexU043324
Consensus CDS ProjectCCDS26431.1
International Mouse Knockout Project StatusSerpinb9
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000696 VEGA Gene Model | MGI Sequence Detail 14708 C57BL/6J ±  kb
transcript OTTMUST00000001329 VEGA | MGI Sequence Detail 3472 Not Applicable 
polypeptide OTTMUSP00000000626 VEGA | MGI Sequence Detail 374 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(12) UniProt(1)
Polymorphisms RFLP(2) : SNPs within 2kb(97 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023795 Protease inhibitor I4, serpin, conserved site
InterPro IPR000240 Serpin B9/maspin
InterPro IPR023796 Serpin domain
InterPro IPR000215 Serpin family
References (Earliest) J:26852 Sun J, et al., Gene structure, chromosomal localization, and expression of the murine homologue of human proteinase inhibitor 6 (PI-6) suggests divergence of PI-6 from the ovalbumin serpins. J Biol Chem. 1995 Jul 7;270(27):16089-96
(Latest) J:205809 Azzi J, et al., Serine protease inhibitor 6 plays a critical role in protecting murine granzyme B-producing regulatory T cells. J Immunol. 2013 Sep 1;191(5):2319-27
All references(38)
Other
accession IDs
MGD-MRK-35059, MGI:3035078

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory