Gyk
Gene Detail

Symbol Name ID

Gyk glycerol kinase MGI:106594

Synonyms

D930012N15Rik, GK

Feature Type

protein coding gene

Genetic Map

Chromosome X

39.32 cM, cytoband C-D
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

ChrX:85701937-85776819 bp, - strand From VEGA annotation of GRCm38   74883 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:21848  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Gyk

Human homologs

Human Homolog		GK, glycerol kinase
NCBI Gene ID		2710
neXtProt AC		NX_P32189
Human Synonyms		GK1, GKD
Human Chr (Location)		Xp21.3; chrX:30671476-30749579 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human GK

Alleles and phenotypes

All alleles(6) : Targeted(4) Gene trapped(2)
 

Males hemizygous for a targeted null mutation show postnatal growth retardation, altered fat metabolism with severe hyperglycerolemia and increased free fatty acids, autonomous glucocorticoid synthesis and death by 4 days of age. Female heterozygotes show reduced free fatty acid and glucose levels.

 
Human Diseases Modeled Using Mouse Gyk (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	carbohydrate metabolic process, glycerol-3-phosphate biosynthetic process, ...
Component	cytoplasm, membrane, ...
Function	ATP binding, glycerol kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (180)    Tissues (161)    Images (3)
Theiler Stages: 10, 18, 23, 25, 28

Assay Type	Results
RNA in situ	148
Northern blot	20
RT-PCR	12

cDNA source data(18)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(24) Genomic(2) cDNA(18) Primer pair(2) Other(2)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000017916 (Evidence)
Ensembl Gene Model	ENSMUSG00000025059 (Evidence)
Entrez Gene	14933 (Evidence)
DFCI	TC1574505, TC1589614, TC1593720, TC1596062, TC1605094, TC1615001
DoTS	DT.101313893, DT.530247, DT.94219918, DT.94219924, DT.94261946
NIA Mouse Gene Index	U039513
EC	2.7.1.30
Consensus CDS Project	CCDS41050.1, CCDS53126.1
International Mouse Knockout Project Status	Gyk

Sequences

Length	Strain/Species
genomic	OTTMUSG00000017916	VEGA Gene Model | MGI Sequence Detail	74883	C57BL/6J
transcript	OTTMUST00000043303	VEGA | MGI Sequence Detail	4279	Not Applicable
polypeptide	OTTMUSP00000019465	VEGA | MGI Sequence Detail	559	Not Applicable

All sequences(66) RefSeq(4) UniProt(6)

Polymorphisms

RFLP(1) : SNPs(260 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR018483	Carbohydrate kinase, FGGY, conserved site
InterPro	IPR018485	Carbohydrate kinase, FGGY, C-terminal
InterPro	IPR018484	Carbohydrate kinase, FGGY, N-terminal
InterPro	IPR005999	Glycerol kinase
Protein Ontology	PR:000008010	glycerol kinase

References

(Earliest) J:34208 Huq AH, et al., Isolation, mapping, and functional expression of the mouse X chromosome glycerol kinase gene. Genomics. 1996 Sep 15;36(3):530-4
(Latest) J:174104 Kosuga M, et al., Glycerol homeostasis and metabolism in glycerol kinase carrier mice. Mol Genet Metab. 2011 Jul;103(3):297-9
All references(52)

Other accession IDs

MGD-MRK-35050, MGI:2442000