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Gyk
Gene Detail
Symbol

Name
ID
Gyk
glycerol kinase
MGI:106594
Synonyms
D930012N15Rik, GK
Feature Type
protein coding gene
Genetic Map
Chromosome X
39.32 cM, cytoband C-D
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
ChrX:85701937-85776819 bp, - strand
From VEGA annotation of GRCm38

  74883 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:134743  Vertebrate Homology Class
1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle

HCOP human homology predictions: GK
Gene Tree: Gyk

Human
homologs
GK, glycerol kinase
Orthology source: HGNC

IDs:
NCBI Gene ID: 2710
neXtProt AC: NX_P32189

Human Synonyms: GK1, GKD

Human Chr (Location): Xp21.3; chrX:30653359-30731462 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human GK

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(2) Targeted(6)
Incidental mutations (data from APF )
 
Males hemizygous for a targeted null mutation show postnatal growth retardation, altered fat metabolism with severe hyperglycerolemia and increased free fatty acids, autonomous glucocorticoid synthesis and death by 4 days of age. Female heterozygotes show reduced free fatty acid and glucose levels.
 
Human Diseases Modeled in Mice Using Gyk (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Gyk interacts with 343 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process carbohydrate metabolic process, glucose homeostasis, ...
Component cytoplasm, cytosol, ...
Function ATP binding, glycerol kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (182)    Tissues (169)    Images (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 150
Northern blot 20
RT-PCR 12
cDNA source data(18)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase gk    NEW 
Molecular
reagents
All nucleic(24) Genomic(2) cDNA(18) Primer pair(2) Other(2)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000017916 (Evidence)
Ensembl Gene Model ENSMUSG00000025059 (Evidence)
Entrez Gene 14933 (Evidence)
DFCI TC1615001, TC1605094, TC1596062, TC1593720, TC1589614, TC1574505
DoTS DT.101313893, DT.94219924, DT.94219918, DT.530247, DT.94261946
NIA Mouse Gene Index U039513
EC 2.7.1.30
Consensus CDS Project CCDS41050.1, CCDS53126.1
International Mouse Phenotyping Consortium Status Gyk
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017916 VEGA Gene Model | MGI Sequence Detail 74883 C57BL/6J ±  kb
transcript OTTMUST00000043303 VEGA | MGI Sequence Detail 4279 Not Applicable 
polypeptide OTTMUSP00000019465 VEGA | MGI Sequence Detail 559 Not Applicable 

For the selected sequences
All sequences(75) RefSeq(14) UniProt(5)
Polymorphisms
RFLP(1) : SNPs within 2kb(273 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018483 Carbohydrate kinase, FGGY, conserved site
InterPro IPR018485 Carbohydrate kinase, FGGY, C-terminal
InterPro IPR018484 Carbohydrate kinase, FGGY, N-terminal
InterPro IPR005999 Glycerol kinase
Protein Ontology PR:000008010 glycerol kinase
References
(Earliest) J:34208 Huq AH, et al., Isolation, mapping, and functional expression of the mouse X chromosome glycerol kinase gene. Genomics. 1996 Sep 15;36(3):530-4
(Latest) J:218247 Cossette SM, et al., Sucrose non-fermenting related kinase enzyme is essential for cardiac metabolism. Biol Open. 2014;4(1):48-61
All references(51)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-35050, MGI:2442000

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory