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Gk Gene Detail
Summary
  • Symbol
    Gk
  • Name
    glycerol kinase
  • Synonyms
    D930012N15Rik, Gyk
  • Feature Type
    protein coding gene
  • IDs
    MGI:106594
    NCBI Gene: 14933
  • Alliance
Location & Maps
more
  • Sequence Map
    ChrX:85701937-85776819 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      74883 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome X, 39.32 cM, cytoband C-D
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    GK, glycerol kinase
  • Vertebrate Orthologs
    5
  • Human Ortholog
    GK, glycerol kinase
    Orthology source: HGNC
  • Synonyms
    GK1, GKD
  • Links
    NCBI Gene ID: 2710
    neXtProt AC: NX_P32189
    UniProt: P32189

  • Chr Location
    Xp21.2; chrX:30653348-30731462 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Gk mouse models; 1 with human GK associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 1 allele in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Males hemizygous for a targeted null mutation show postnatal growth retardation, altered fat metabolism with severe hyperglycerolemia and increased free fatty acids, autonomous glucocorticoid synthesis and death by 4 days of age. Female heterozygotes show reduced free fatty acid and glucose levels.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000017916 VEGA Gene Model | MGI Sequence Detail 74883 C57BL/6J ±  kb
    transcript OTTMUST00000043303 VEGA | MGI Sequence Detail 4279 Not Applicable  
    polypeptide OTTMUSP00000019465 VEGA | MGI Sequence Detail 559 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      273 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      Genomic 2
      cDNA 20
      Primer pair 2
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-35050, MGI:2442000
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 6
      Diseases 2
      Gene Ontology 11
      Phenotypes 12
    • Earliest
      J:34208 Huq AH, et al., Isolation, mapping, and functional expression of the mouse X chromosome glycerol kinase gene. Genomics. 1996 Sep 15;36(3):530-4
    • Latest
      J:218247 Cossette SM, et al., Sucrose non-fermenting related kinase enzyme is essential for cardiac metabolism. Biol Open. 2014;4(1):48-61

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory