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Neurod6 Gene Detail
Summary
  • Symbol
    Neurod6
  • Name
    neurogenic differentiation 6
  • Synonyms
    Atoh2, bHLHa2, Math2, Math-2, Nex, Nex1m
  • Feature Type
    protein coding gene
  • IDs
    MGI:106593
    NCBI Gene: 11922
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:55677822-55681263 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 27.53 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    42 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106593
protein coding gene Chr6:55677818-55681263 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030775
protein coding gene Chr6:55095293-55098742 (-)
A/J MGP_AJ_G0030744
protein coding gene Chr6:52533597-52537038 (-)
AKR/J MGP_AKRJ_G0030671
protein coding gene Chr6:54311162-54314603 (-)
BALB/cJ MGP_BALBcJ_G0030756
protein coding gene Chr6:52915829-52919270 (-)
C3H/HeJ MGP_C3HHeJ_G0030469
protein coding gene Chr6:54344542-54347985 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031211
protein coding gene Chr6:56320547-56323976 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028417
protein coding gene Chr6:50139554-50142998 (-)
CAST/EiJ MGP_CASTEiJ_G0029872
protein coding gene Chr6:54206368-54209819 (-)
CBA/J MGP_CBAJ_G0030443
protein coding gene Chr6:58613124-58616565 (-)
DBA/2J MGP_DBA2J_G0030593
protein coding gene Chr6:52433004-52436445 (-)
FVB/NJ MGP_FVBNJ_G0030545
protein coding gene Chr6:52033454-52036895 (-)
LP/J MGP_LPJ_G0030678
protein coding gene Chr6:55021577-55025026 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030579
protein coding gene Chr6:61119550-61122991 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031241
protein coding gene Chr6:54286359-54289806 (-)
PWK/PhJ MGP_PWKPhJ_G0029585
protein coding gene Chr6:52102354-52105871 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029419
protein coding gene Chr6:53666735-53670175 (-)
WSB/EiJ MGP_WSBEiJ_G0029949
protein coding gene Chr6:54325149-54328589 (-)



Homology
more
  • Human Ortholog
    NEUROD6, neuronal differentiation 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NEUROD6, neuronal differentiation 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Atoh2, bHLHa2, Math-2, MATH2, Nex1, NEX1M
  • Links
    NCBI Gene ID: 63974
    neXtProt AC: NX_Q96NK8
    UniProt: Q96NK8

  • Chr Location
    7p14.3; chr7:31337461-31340924 (-)  GRCh38.p7

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    47 phenotypes from multigenic genotypes
    162 phenotype references
Mice homozygous for a targeted null mutation are viable and fertile and exhibit an apparently normal differentiation of CNS neurons with no obvious behavioral or motor abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000037984 Ensembl Gene Model | MGI Sequence Detail 3442 C57BL/6J ±  kb
transcript ENSMUST00000044767 Ensembl | MGI Sequence Detail 2150 Not Applicable  
polypeptide ENSMUSP00000047016 Ensembl | MGI Sequence Detail 337 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000011155 neurogenic differentiation factor 6
  • InterPro Domains
    IPR036638 Helix-loop-helix DNA-binding domain superfamily
    IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
    IPR032650 Neurogenic differentiation factor 6
    IPR022575 Neurogenic differentiation factor, domain of unknown function
    IPR016637 Neurogenic differentiation factor NeuroD
Molecular
Reagents
less
  • All nucleic 29
    Genomic 2
    cDNA 20
    Primer pair 4
    Other 3

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-35049
References
more
  • Summaries
    All 242
    Developmental Gene Expression 56
    Diseases 1
    Gene Ontology 4
    Phenotypes 162
  • Earliest
    J:33073 Bartholoma A, et al., NEX-1: a novel brain-specific helix-loop-helix protein with autoregulation and sustained expression in mature cortical neurons. Mech Dev. 1994 Dec;48(3):217-28
  • Latest
    J:266242 Desmaris E, et al., DMRT5, DMRT3, and EMX2 Cooperatively Repress Gsx2 at the Pallium-Subpallium Boundary to Maintain Cortical Identity in Dorsal Telencephalic Progenitors. J Neurosci. 2018 Oct 17;38(42):9105-9121

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory