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Neurod6 Gene Detail
Summary
  • Symbol
    Neurod6
  • Name
    neurogenic differentiation 6
  • Synonyms
    Atoh2, bHLHa2, Math2, Math-2, Nex, Nex1m
  • Feature Type
    protein coding gene
  • IDs
    MGI:106593
    NCBI Gene: 11922
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr6:55677822-55681263 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3442 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 27.53 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    NEUROD6, neuronal differentiation 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NEUROD6, neuronal differentiation 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Atoh2, bHLHa2, Math-2, MATH2, Nex1, NEX1M
  • Links
    NCBI Gene ID: 63974
    neXtProt AC: NX_Q96NK8
    UniProt: Q96NK8

  • Chr Location
    7p14.3; chr7:31337461-31340924 (-)  GRCh38.p7

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    47 phenotypes from multigenic genotypes
    161 phenotype references
Mice homozygous for a targeted null mutation are viable and fertile and exhibit an apparently normal differentiation of CNS neurons with no obvious behavioral or motor abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000057889 VEGA Gene Model | MGI Sequence Detail 3442 C57BL/6J ±  kb
transcript OTTMUST00000142150 VEGA | MGI Sequence Detail 2150 Not Applicable  
polypeptide OTTMUSP00000074206 VEGA | MGI Sequence Detail 337 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    42 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000011155 neurogenic differentiation factor 6
  • InterPro Domains
    IPR036638 Helix-loop-helix DNA-binding domain superfamily
    IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
    IPR032650 Neurogenic differentiation factor 6
    IPR022575 Neurogenic differentiation factor, domain of unknown function
    IPR016637 Neurogenic differentiation factor NeuroD
Molecular
Reagents
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  • All nucleic 29
    Genomic 2
    cDNA 20
    Primer pair 4
    Other 3

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-35049
References
more
  • Summaries
    All 241
    Developmental Gene Expression 55
    Diseases 1
    Gene Ontology 4
    Phenotypes 161
  • Earliest
    J:33073 Bartholoma A, et al., NEX-1: a novel brain-specific helix-loop-helix protein with autoregulation and sustained expression in mature cortical neurons. Mech Dev. 1994 Dec;48(3):217-28
  • Latest
    J:264833 Engel M, et al., The Role of m(6)A/m-RNA Methylation in Stress Response Regulation. Neuron. 2018 Jul 25;99(2):389-403.e9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/16/2018
MGI 6.12
The Jackson Laboratory