Neurod6
Gene Detail

Symbol Name ID

Neurod6 neurogenic differentiation 6 MGI:106593

Synonyms

Atoh2, bHLHa2, Math2, Math-2, Nex, Nex1m

Feature Type

protein coding gene

Genetic Map

Chromosome 6

27.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr6:55677818-55681263 bp, - strand From NCBI annotation of GRCm38   3446 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7632  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: basic helix-loop-helix transcription factor NeuroD
Gene Tree: Neurod6

Human homologs

Human Homolog		NEUROD6, neuronal differentiation 6
NCBI Gene ID		63974
neXtProt AC		NX_Q96NK8
Human Synonyms		Atoh2, bHLHa2, Math-2, MATH2, Nex1, NEX1M
Human Chr (Location)		7p14.3; chr7:31377079-31380538 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Mice homozygous for a targeted null mutation are viable and fertile and exhibit an apparently normal differentiation of CNS neurons with no obvious behavioral or motor abnormalities.

 

Gene Ontology (GO) classifications

All GO classifications: (9 annotations)

Process	cell differentiation, dentate gyrus development, ...
Component	nucleus
Function	DNA binding, protein dimerization activity

External Resources: FuncBase

Expression

Literature Summary: (41 records)
Data Summary: Results (304)    Tissues (170)    Images (66)
Theiler Stages: 17, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	281
In situ reporter (knock in)	16
RT-PCR	7

cDNA source data(18)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(26) Genomic(2) cDNA(19) Primer pair(4) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000037984 (Evidence)
Entrez Gene	11922 (Evidence)
UniGene	5106
DFCI	TC1580357
DoTS	DT.87067479
NIA Mouse Gene Index	U027350
Consensus CDS Project	CCDS20168.1
International Mouse Knockout Project Status	Neurod6

Sequences

Length	Strain/Species
genomic	11922	NCBI Gene Model | MGI Sequence Detail	3446	C57BL/6J
transcript	NM_009717	RefSeq | MGI Sequence Detail	2154	C57BL/6
polypeptide	P48986	UniProt | EBI | MGI Sequence Detail	337	Not Applicable

All sequences(19) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(1) : SNPs(23 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011598	Helix-loop-helix domain
InterPro	IPR022575	Neurogenic differentiation factor, domain of unknown function
InterPro	IPR016637	Transcription factor, basic helix-loop-helix, NeuroD
Protein Ontology	PR:000011155	neurogenic differentiation factor 6

Graphical View of Protein Domain Structure

References

(Earliest) J:33073 Bartholoma A, et al., NEX-1: a novel brain-specific helix-loop-helix protein with autoregulation and sustained expression in mature cortical neurons. Mech Dev. 1994 Dec;48(3):217-28
(Latest) J:193914 Steindel F, et al., Neuron-type specific cannabinoid-mediated G protein signalling in mouse hippocampus. J Neurochem. 2013 Mar;124(6):795-807
All references(143)

Other accession IDs

MGD-MRK-35049