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Neurod6
Gene Detail
 Symbol
Name
ID
Neurod6
neurogenic differentiation 6
MGI:106593
Synonyms Atoh2, bHLHa2, Math2, Math-2, Nex, Nex1m
Feature Type protein coding gene
Genetic Map
Chromosome 6
27.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr6:55677818-55681263 bp, - strand
From NCBI annotation of GRCm38

  3446 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7632  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: basic helix-loop-helix transcription factor NeuroD
Gene Tree: Neurod6

Human
homologs
Human Homolog NEUROD6, neuronal differentiation 6
NCBI Gene ID 63974
neXtProt AC  NX_Q96NK8
Human Synonyms  Atoh2, bHLHa2, Math-2, MATH2, Nex1, NEX1M
Human Chr (Location)  7p14.3; chr7:31337461-31340924 (-)  GRCh38
Alleles
and
phenotypes
All alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted null mutation are viable and fertile and exhibit an apparently normal differentiation of CNS neurons with no obvious behavioral or motor abnormalities.
 
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process cell differentiation, dentate gyrus development, ...
Component nucleus
Function DNA binding, protein dimerization activity
External Resources: FuncBase
Expression
Literature Summary: (41 records)
Data Summary: Results (355)    Tissues (220)    Images (70)
Theiler Stages: 17, 19, 20, 21, 22, 23, 24, 26, 28
Assay TypeResults
RNA in situ 332
In situ reporter (knock in) 16
RT-PCR 7
cDNA source data(18)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(27) Genomic(2) cDNA(19) Primer pair(4) Other(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000037984 (Evidence)
Entrez Gene11922 (Evidence)
UniGene5106
DFCITC1580357
DoTSDT.87067479
NIA Mouse Gene IndexU027350
Consensus CDS ProjectCCDS20168.1
International Mouse Knockout Project StatusNeurod6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 11922 NCBI Gene Model | MGI Sequence Detail 3446 C57BL/6J ±  kb
transcript NM_009717 RefSeq | MGI Sequence Detail 2154 C57BL/6 
polypeptide P48986 UniProt | EBI | MGI Sequence Detail 337 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(2) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(42 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
InterPro IPR022575 Neurogenic differentiation factor, domain of unknown function
InterPro IPR016637 Transcription factor, basic helix-loop-helix, NeuroD
Protein Ontology PR:000011155 neurogenic differentiation factor 6
Graphical View of Protein Domain Structure
References (Earliest) J:33073 Bartholoma A, et al., NEX-1: a novel brain-specific helix-loop-helix protein with autoregulation and sustained expression in mature cortical neurons. Mech Dev. 1994 Dec;48(3):217-28
(Latest) J:208651 Louvi A, et al., Ccm3, a gene associated with cerebral cavernous malformations, is required for neuronal migration. Development. 2014 Mar;141(6):1404-15
All references(155)
Other
accession IDs
MGD-MRK-35049

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory