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Neurod6
Gene Detail
Symbol

Name
ID
Neurod6
neurogenic differentiation 6
MGI:106593
Synonyms
Atoh2, bHLHa2, Math2, Math-2, Nex, Nex1m
Feature Type
protein coding gene
Genetic Map
Chromosome 6
27.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr6:55677818-55681263 bp, - strand
From NCBI annotation of GRCm38

  3446 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7632  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NEUROD6
Protein SuperFamily: basic helix-loop-helix transcription factor NeuroD
Gene Tree: Neurod6

Human
homologs
NEUROD6, neuronal differentiation 6
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 63974
neXtProt AC: NX_Q96NK8

Human Synonyms: Atoh2, bHLHa2, Math-2, MATH2, Nex1, NEX1M

Human Chr (Location): 7p14.3; chr7:31337461-31340924 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted null mutation are viable and fertile and exhibit an apparently normal differentiation of CNS neurons with no obvious behavioral or motor abnormalities.
 
Interactions
Neurod6 interacts with 234 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process cell differentiation, dentate gyrus development, ...
Component nucleus
Function DNA binding, protein dimerization activity, ...
External Resources: FuncBase
Expression
Literature Summary: (45 records)
Data Summary: Results (355)    Tissues (220)    Images (70)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 332
In situ reporter (knock in) 16
RT-PCR 7
cDNA source data(18)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA NEUROD6 ; Xenbase neurod6 ; ZFIN neurod6a, neurod6b    NEW 
Molecular
reagents
All nucleic(27) Genomic(2) cDNA(19) Primer pair(4) Other(2)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000037984 (Evidence)
Entrez Gene 11922 (Evidence)
UniGene 5106
DFCI TC1580357
DoTS DT.87067479
NIA Mouse Gene Index U027350
Consensus CDS Project CCDS20168.1
International Mouse Phenotyping Consortium Status Neurod6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 11922 NCBI Gene Model | MGI Sequence Detail 3446 C57BL/6J ±  kb
transcript NM_009717 RefSeq | MGI Sequence Detail 2154 C57BL/6 
polypeptide P48986 UniProt | EBI | MGI Sequence Detail 337 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(42 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
InterPro IPR022575 Neurogenic differentiation factor, domain of unknown function
InterPro IPR016637 Transcription factor, basic helix-loop-helix, NeuroD
Protein Ontology PR:000011155 neurogenic differentiation factor 6
Graphical View of Protein Domain Structure
References
(Earliest) J:33073 Bartholoma A, et al., NEX-1: a novel brain-specific helix-loop-helix protein with autoregulation and sustained expression in mature cortical neurons. Mech Dev. 1994 Dec;48(3):217-28
(Latest) J:219935 Monory K, et al., Cannabinoid CB1 Receptor Calibrates Excitatory Synaptic Balance in the Mouse Hippocampus. J Neurosci. 2015 Mar 4;35(9):3842-50
All references(167)
Other
accession IDs
MGD-MRK-35049

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory