About   Help   FAQ
Has1
Gene Detail
 Symbol
Name
ID
Has1
hyaluronan synthase1
MGI:106590
Feature Type protein coding gene
Genetic Map
Chromosome 17
10.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:17843328-17855188 bp, - strand
From Ensembl annotation of GRCm38

  11861 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1165  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Has1

Human
homologs
Human Homolog HAS1, hyaluronan synthase 1
NCBI Gene ID 3036
neXtProt AC  NX_Q92839
Human Synonyms  HAS
Human Chr (Location)  19q13.4; chr19:51713112-51723986 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele are viable and appear grossly normal.
 
Interactions
Has1 interacts with 47 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process cellular response to platelet-derived growth factor stimulus, extracellular matrix assembly, ...
Component integral component of membrane, membrane
Function hyaluronan synthase activity, transferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (94)    Tissues (94)   
Theiler Stages: 22
Assay TypeResults
RNA in situ 94
cDNA source data(7)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(8) Genomic(1) cDNA(7)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000003665 (Evidence)
Entrez Gene15116 (Evidence)
UniGene255701
DFCITC1588977
DoTSDT.87040281, DT.91557173
NIA Mouse Gene IndexU037463
EC2.4.1.212
Consensus CDS ProjectCCDS37459.1
International Mouse Knockout Project StatusHas1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000003665 Ensembl Gene Model | MGI Sequence Detail 11861 C57BL/6J ±  kb
transcript ENSMUST00000003762 Ensembl | MGI Sequence Detail 2090 Not Applicable 
polypeptide ENSMUSP00000003762 Ensembl | MGI Sequence Detail 583 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(2) UniProt(4)
Polymorphisms RFLP(1) : SNPs within 2kb(294 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026107 Hyaluronan synthase/nodulation protein C
Protein Ontology PR:000008449 hyaluronan synthase 1
References (Earliest) J:5771 Holmes RS, Genetics of peroxisomal enzymes in the mouse: nonlinkage of D-amino acid oxidase locus (Dao) to catalase (Cs) and L-alpha-hydroxyacid oxidase (Hao-1) loci on chromosome 2. Biochem Genet. 1976 Dec;14(11-12):981-7
(Latest) J:210601 Arranz AM, et al., Hyaluronan deficiency due to Has3 knock-out causes altered neuronal activity and seizures via reduction in brain extracellular space. J Neurosci. 2014 Apr 30;34(18):6164-76
All references(44)
Other
accession IDs
MGD-MRK-35046

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/23/2014
MGI 5.19
The Jackson Laboratory