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Hivep3 Gene Detail
Summary
  • Symbol
    Hivep3
  • Name
    human immunodeficiency virus type I enhancer binding protein 3
  • Synonyms
    2900056N03Rik, E030045D18Rik, Krc, Schnurri-3, Shn3
  • Feature Type
    protein coding gene
  • IDs
    MGI:106589
    NCBI Gene: 16656
  • Gene Overview
    MyGene.info: HIVEP3
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr4:119733784-120138045 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      404262 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 55.51 cM, cytoband D1
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    HIVEP3, human immunodeficiency virus type I enhancer binding protein 3
  • Vertebrate Orthologs
    11
  • Human Ortholog
    HIVEP3, human immunodeficiency virus type I enhancer binding protein 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    KBP1, KBP-1, KRC, Schnurri-3, SHN3, ZAS3, ZNF40C
  • Links
    NCBI Gene ID: 59269
    neXtProt AC: NX_Q5T1R4
    UniProt: Q5T1R4

  • Chr Location
    1p34.2; chr1:41506365-42035925 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 7803
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: HIVEP3
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 4 alleles in 6 genetic backgrounds
    8 phenotypes from multigenic genotypes
    6 images
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in diminished IL-2 production by stimulated CD4 cells. Mice homozygous for a knock-out allele exhibit increased bone volume.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000008783 VEGA Gene Model | MGI Sequence Detail 404262 C57BL/6J ±  kb
    transcript OTTMUST00000019962 VEGA | MGI Sequence Detail 11838 Not Applicable  
    polypeptide OTTMUSP00000009157 VEGA | MGI Sequence Detail 2348 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      2321 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      Genomic 1
      cDNA 19
      Primer pair 1

      Microarray probesets 11
    Other
    Accession IDs
    less
    MGD-MRK-35045, MGI:1920253, MGI:2140378, MGI:2443550
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 5
      Gene Ontology 6
      Phenotypes 19
    • Earliest
      J:15696 Wu LC, et al., Molecular cloning of a zinc finger protein which binds to the heptamer of the signal sequence for V(D)J recombination. Nucleic Acids Res. 1993 Nov 11;21(22):5067-73
    • Latest
      J:223511 Wei J, et al., Glucose Uptake and Runx2 Synergize to Orchestrate Osteoblast Differentiation and Bone Formation. Cell. 2015 Jun 18;161(7):1576-91

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    06/05/2018
    MGI 6.12
    The Jackson Laboratory