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Hivep3
Gene Detail
Symbol

Name
ID
Hivep3
human immunodeficiency virus type I enhancer binding protein 3
MGI:106589
Synonyms
2900056N03Rik, E030045D18Rik, Krc, Schnurri-3, Shn3
Feature Type
protein coding gene
Genetic Map
Chromosome 4
55.51 cM, cytoband D1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:119733784-120138045 bp, + strand
From VEGA annotation of GRCm38

  404262 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7803  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: HIVEP3
Gene Tree: Hivep3

Human
homologs
HIVEP3, human immunodeficiency virus type I enhancer binding protein 3
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 59269
neXtProt AC: NX_Q5T1R4

Human Synonyms: KBP1, KBP-1, KRC, Schnurri-3, SHN3, ZAS3, ZNF40C

Human Chr (Location): 1p34; chr1:41506365-42035931 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(31) : Gene trapped(25) Targeted(6)
Genomic Mutations involving Hivep3 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutation of this gene results in diminished IL-2 production by stimulated CD4 cells. Mice homozygous for a knock-out allele exhibit increased bone volume.
 
Interactions
Hivep3 interacts with 501 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process positive regulation of transcription, DNA-templated, regulation of transcription, DNA-templated, ...
Component cytoplasm, nucleus
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (60)    Tissues (39)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 52
RT-PCR 8
cDNA source data(18)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase hivep3    NEW 
Molecular
reagents
All nucleic(21) Genomic(1) cDNA(19) Primer pair(1)
Microarray probesets(11)
Other database
links
VEGA Gene Model OTTMUSG00000008783 (Evidence)
Ensembl Gene Model ENSMUSG00000028634 (Evidence)
Entrez Gene 16656 (Evidence)
DFCI TC1584815, TC1601130, TC1599466, TC1716827, TC1612169, TC1625628, TC1624161, TC1613028, TC1760883, TC1733691
DoTS DT.55265477, DT.55241468, DT.523658, DT.102535456, DT.91330589, DT.87057946, DT.87028023, DT.94029157, DT.97341660, DT.94224995
NIA Mouse Gene Index U136296, U210195
Consensus CDS Project CCDS38863.1
International Mouse Phenotyping Consortium Status Hivep3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008783 VEGA Gene Model | MGI Sequence Detail 404262 C57BL/6J ±  kb
transcript OTTMUST00000019962 VEGA | MGI Sequence Detail 11838 Not Applicable 
polypeptide OTTMUSP00000009157 VEGA | MGI Sequence Detail 2348 Not Applicable 

For the selected sequences
All sequences(92) RefSeq(15) UniProt(5)
Polymorphisms
SNPs within 2kb(2356 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000008606 transcription factor HIVEP3
References
(Earliest) J:15696 Wu LC, et al., Molecular cloning of a zinc finger protein which binds to the heptamer of the signal sequence for V(D)J recombination. Nucleic Acids Res. 1993 Nov 11;21(22):5067-73
(Latest) J:201597 Shim JH, et al., Schnurri-3 regulates ERK downstream of WNT signaling in osteoblasts. J Clin Invest. 2013 Sep 3;123(9):4010-22
All references(47)
Other
accession IDs
MGD-MRK-35045, MGI:1920253, MGI:2140378, MGI:2443550

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory