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Hivep3
Gene Detail
Symbol

Name
ID
Hivep3
human immunodeficiency virus type I enhancer binding protein 3
MGI:106589
Synonyms
2900056N03Rik, E030045D18Rik, Krc, Schnurri-3, Shn3
Feature Type
protein coding gene
Genetic Map
Chromosome 4
55.51 cM, cytoband D1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:119733784-120138045 bp, + strand
From VEGA annotation of GRCm38

  404262 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7803  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Human
homologs
Human Homolog HIVEP3, human immunodeficiency virus type I enhancer binding protein 3
NCBI Gene ID 59269
neXtProt AC  NX_Q5T1R4
Human Synonyms  KBP1, KBP-1, KRC, Schnurri-3, SHN3, ZAS3, ZNF40C
Human Chr (Location)  1p34; chr1:41506365-42035925 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(30) : Gene trapped(25) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in diminished IL-2 production by stimulated CD4 cells. Mice homozygous for a knock-out allele exhibit increased bone volume.
 
Interactions
Hivep3 interacts with 501 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process positive regulation of transcription, DNA-templated, regulation of transcription, DNA-templated, ...
Component cytoplasm, nucleus
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (60)    Tissues (39)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 52
RT-PCR 8
cDNA source data(18)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(21) Genomic(1) cDNA(19) Primer pair(1)
Microarray probesets(11)
Other database
links
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008783 VEGA Gene Model | MGI Sequence Detail 404262 C57BL/6J ±  kb
transcript OTTMUST00000019962 VEGA | MGI Sequence Detail 11838 Not Applicable 
polypeptide OTTMUSP00000009157 VEGA | MGI Sequence Detail 2348 Not Applicable 

For the selected sequences
All sequences(87) RefSeq(9) UniProt(5)
Polymorphisms
SNPs within 2kb(2356 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000008606 transcription factor HIVEP3
References
(Earliest) J:15696 Wu LC, et al., Molecular cloning of a zinc finger protein which binds to the heptamer of the signal sequence for V(D)J recombination. Nucleic Acids Res. 1993 Nov 11;21(22):5067-73
(Latest) J:201597 Shim JH, et al., Schnurri-3 regulates ERK downstream of WNT signaling in osteoblasts. J Clin Invest. 2013 Sep 3;123(9):4010-22
All references(49)
Other
accession IDs
MGD-MRK-35045, MGI:1920253, MGI:2140378, MGI:2443550

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory