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Omg Gene Detail
Summary
  • Symbol
    Omg
  • Name
    oligodendrocyte myelin glycoprotein
  • Feature Type
    protein coding gene
  • IDs
    MGI:106586
    NCBI Gene: 18377
  • Gene Overview
    MyGene.info: OMG
Location & Maps
more
  • Sequence Map
    Chr11:79500982-79504084 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3103 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    OMG, oligodendrocyte myelin glycoprotein
  • Vertebrate Orthologs
    9
  • Human Ortholog
    OMG, oligodendrocyte myelin glycoprotein
    Orthology source: HGNC, HomoloGene
  • Synonyms
    OMGP
  • Links
    NCBI Gene ID: 4974
    neXtProt AC: NX_P23515

  • Chr Location
    17q11.2; chr17:31294650-31297362 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 36099
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog
  • HCOP
    human homology predictions: OMG
  • Gene Tree
    Omg
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 3 alleles in 4 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Targeted
    7
  • Genomic Mutations
    2 involving Omg
  • Incidental Mutations
Mice homozygous for a null allele exhibit improved recovery from spinal cord injuries when on a mixed 129S4/SvJae C57BL/6 background.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000194 VEGA Gene Model | MGI Sequence Detail 3103 C57BL/6J ±  kb
transcript OTTMUST00000000577 VEGA | MGI Sequence Detail 2228 Not Applicable  
polypeptide OTTMUSP00000000249 VEGA | MGI Sequence Detail 443 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    15 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000011637 oligodendrocyte-myelin glycoprotein
  • InterPro Domains
    IPR001611 Leucine-rich repeat
    IPR032675 Leucine-rich repeat domain, L domain-like
    IPR000372 Leucine-rich repeat N-terminal domain
    IPR003591 Leucine-rich repeat, typical subtype
Molecular
Reagents
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  • All nucleic 13
    Genomic 2
    cDNA 10
    Primer pair 1

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-35042
References
more
  • Summaries
    All 34
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 18
  • Earliest
    J:8591 Lebar R, et al., The M2 autoantigen of central nervous system myelin, a glycoprotein present in oligodendrocyte membrane. Clin Exp Immunol. 1986 Nov;66(2):423-34
  • Latest
    J:207231 Nishino J, et al., A network of heterochronic genes including Imp1 regulates temporal changes in stem cell properties. Elife. 2013;2:e00924

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory