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Tsg101
Gene Detail
Symbol

Name
ID
Tsg101
tumor susceptibility gene 101
MGI:106581
Synonyms
CC2
Feature Type
protein coding gene
Genetic Map
Chromosome 7
30.62 cM, cytoband B5
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr7:46888949-46919969 bp, - strand
From VEGA annotation of GRCm38

  31021 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4584  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: ESCRT-1 complex, Vps23 subunit
Gene Tree: Tsg101

Human
homologs
Human Homolog TSG101, tumor susceptibility 101
NCBI Gene ID 7251
neXtProt AC  NX_Q99816
Human Synonyms  TSG10, VPS23
Human Chr (Location)  11p15; chr11:18480311-18526956 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human TSG101
Mutations,
alleles, and
phenotypes
All mutations/alleles(19) : Gene trapped(12) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit reduced growth, fail to form mesoderm, accumulate p53 protein and die by embryonic day 6.5. Homozygotes for a mammary gland-specific knockout show impaired mammogenesis and are unable to nurse their pups.
 
Interactions
Tsg101 interacts with 174 markers (Mir7-1, Mir10a, Mir16-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (42 annotations)
Process cell cycle, cell cycle arrest, ...
Component cytoplasm, early endosome, ...
Function calcium-dependent protein binding, ligand-dependent nuclear receptor transcription coactivator activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (106)    Tissues (55)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 60
RT-PCR 46
cDNA source data(129)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(132) Genomic(1) cDNA(129) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000024345 (Evidence)
Ensembl Gene ModelENSMUSG00000014402 (Evidence)
Entrez Gene22088 (Evidence)
UniGene241334
DFCITC1572931
DoTSDT.494757, DT.101403393
NIA Mouse Gene IndexU028567, U016294
Consensus CDS ProjectCCDS21291.1
International Mouse Knockout Project StatusTsg101
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024345 VEGA Gene Model | MGI Sequence Detail 31021 C57BL/6J ±  kb
transcript OTTMUST00000059640 VEGA | MGI Sequence Detail 1949 Not Applicable 
polypeptide OTTMUSP00000029024 VEGA | MGI Sequence Detail 391 Not Applicable 

For the selected sequences
All sequences(63) RefSeq(9) UniProt(11)
Polymorphisms
SNPs within 2kb(149 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017916 Steadiness box
InterPro IPR016135 Ubiquitin-conjugating enzyme/RWD-like
InterPro IPR008883 Ubiquitin E2 variant, N-terminal
Protein Ontology PR:000016719 tumor susceptibility gene 101 protein
References
(Earliest) J:51752 Maucuer A, et al., Stathmin interaction with a putative kinase and coiled-coil-forming protein domains. Proc Natl Acad Sci U S A. 1995 Apr 11;92(8):3100-4
(Latest) J:193940 Gross JC, et al., Active Wnt proteins are secreted on exosomes. Nat Cell Biol. 2012 Oct;14(10):1036-45
All references(62)
Other
accession IDs
MGD-MRK-35037, MGI:2141888

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory