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Chpf Gene Detail
Summary
  • Symbol
    Chpf
  • Name
    chondroitin polymerizing factor
  • Synonyms
    1700028N03Rik, D1Bwg1363e
  • Feature Type
    protein coding gene
  • IDs
    MGI:106576
    NCBI Gene: 74241
  • Gene Overview
    MyGene.info: CHPF
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:75474569-75479307 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 39.14 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    23 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106576
protein coding gene Chr1:75474569-75479471 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016189
protein coding gene Chr1:76052328-76057118 (-)
A/J MGP_AJ_G0016172
protein coding gene Chr1:73398641-73403393 (-)
AKR/J MGP_AKRJ_G0016129
protein coding gene Chr1:75432581-75437317 (-)
BALB/cJ MGP_BALBcJ_G0016127
protein coding gene Chr1:73461245-73465990 (-)
C3H/HeJ MGP_C3HHeJ_G0015958
protein coding gene Chr1:75765482-75770223 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016580
protein coding gene Chr1:79006531-79011277 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014301
protein coding gene Chr1:68957771-68962281 (-)
CAST/EiJ MGP_CASTEiJ_G0015542
protein coding gene Chr1:75110482-75115218 (-)
CBA/J MGP_CBAJ_G0015931
protein coding gene Chr1:81584056-81588798 (-)
DBA/2J MGP_DBA2J_G0016032
protein coding gene Chr1:72717990-72722729 (-)
FVB/NJ MGP_FVBNJ_G0016035
protein coding gene Chr1:71924154-71928892 (-)
LP/J MGP_LPJ_G0016104
protein coding gene Chr1:77179700-77184438 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016055
protein coding gene Chr1:84918594-84923330 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016627
protein coding gene Chr1:75502474-75507207 (-)
PWK/PhJ MGP_PWKPhJ_G0015329
protein coding gene Chr1:72193945-72199120 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015107
protein coding gene Chr1:74858437-74862800 (-)
WSB/EiJ MGP_WSBEiJ_G0015604
protein coding gene Chr1:75312045-75316776 (-)



Homology
more
  • Human Ortholog
    CHPF, chondroitin polymerizing factor
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CHPF, chondroitin polymerizing factor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CHSY2, CSS2
  • Links
    NCBI Gene ID: 79586
    neXtProt AC: NX_Q8IZ52
    UniProt: Q8IZ52

  • Chr Location
    2q35; chr2:219538947-219543765 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 11574
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CHPF
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 3 alleles in 2 genetic backgrounds
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mice are viable and no detectable mutant phenotype is reported. Mice homozygous for another knock-out allele exhibit slight reduction in femur and tibia length.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032997 Ensembl Gene Model | MGI Sequence Detail 4739 C57BL/6J ±  kb
    transcript ENSMUST00000079205 Ensembl | MGI Sequence Detail 2892 Not Applicable  
    polypeptide ENSMUSP00000078199 Ensembl | MGI Sequence Detail 774 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 59
      Genomic 2
      cDNA 56
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-34270, MGI:1921491, MGI:2138222
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 6
      Phenotypes 26
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:191659 Ogawa H, et al., Chondroitin sulfate synthase-2 is necessary for chain extension of chondroitin sulfate but not critical for skeletal development. PLoS One. 2012;7(8):e43806

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory