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Chpf Gene Detail
Summary
  • Symbol
    Chpf
  • Name
    chondroitin polymerizing factor
  • Synonyms
    1700028N03Rik, D1Bwg1363e
  • Feature Type
    protein coding gene
  • IDs
    MGI:106576
    NCBI Gene: 74241
  • Gene Overview
    MyGene.info: CHPF
Location & Maps
more
  • Sequence Map
    Chr1:75474569-75479307 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4739 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 39.14 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    CHPF, chondroitin polymerizing factor
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CHPF, chondroitin polymerizing factor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CHSY2, CSS2
  • Links
    NCBI Gene ID: 79586
    neXtProt AC: NX_Q8IZ52

  • Chr Location
    2q35; chr2:219538947-219543765 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 11574
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CHPF
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 3 alleles in 2 genetic backgrounds
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Radiation induced
    2
  • Spontaneous
    1
  • Targeted
    6
  • Genomic Mutations
    4 involving Chpf
  • Incidental Mutations
Homozygous mice are viable and no detectable mutant phenotype is reported. Mice homozygous for another knock-out allele exhibit slight reduction in femur and tibia length.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019412 VEGA Gene Model | MGI Sequence Detail 4739 C57BL/6J ±  kb
transcript OTTMUST00000046316 VEGA | MGI Sequence Detail 2892 Not Applicable  
polypeptide OTTMUSP00000020916 VEGA | MGI Sequence Detail 774 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    23 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 58
    Genomic 1
    cDNA 56
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-34270, MGI:1921491, MGI:2138222
References
more
  • Summaries
    All 42
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 6
    Phenotypes 26
  • Earliest
    J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
  • Latest
    J:191659 Ogawa H, et al., Chondroitin sulfate synthase-2 is necessary for chain extension of chondroitin sulfate but not critical for skeletal development. PLoS One. 2012;7(8):e43806

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory