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Tmx4 Gene Detail
Summary
  • Symbol
    Tmx4
  • Name
    thioredoxin-related transmembrane protein 4
  • Synonyms
    2810417D04Rik, 4930500L08Rik, D2Bwg1356e, mKIAA1162, Txndc13
  • Feature Type
    protein coding gene
  • IDs
    MGI:106558
    NCBI Gene: 52837
  • Gene Overview
    MyGene.info: TMX4
Location & Maps
more
  • Sequence Map
    Chr2:134594185-134644145 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      49961 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 65.66 cM, cytoband G1
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    TMX4, thioredoxin related transmembrane protein 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TMX4, thioredoxin related transmembrane protein 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DJ971N18.2, PDIA14, TXNDC13
  • Links
    NCBI Gene ID: 56255
    neXtProt AC: NX_Q9H1E5

  • Chr Location
    20p12; chr20:7977353-8019829 (-)  GRCh38.p2
  • HomoloGene
    Vertebrate Homology Class 10901
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: TMX4
  • Gene Tree
    Tmx4
Human Diseases
less
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotype references
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Radiation induced
    2
  • Targeted
    1
  • Genomic Mutations
    3 involving Tmx4
  • Incidental Mutations
    Mutagenetix , APF , CvDC
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1
  • Tissues
    1
  • cDNA Data
    11
  • Literature Summary
    1
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015451 VEGA Gene Model | MGI Sequence Detail 49961 C57BL/6J ±  kb
transcript OTTMUST00000036670 VEGA | MGI Sequence Detail 5488 Not Applicable  
polypeptide OTTMUSP00000016456 VEGA | MGI Sequence Detail 335 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    103 from dbSNP Build 142
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000030572 thioredoxin-related transmembrane protein 4
  • InterPro Domains
    IPR017937 Thioredoxin, conserved site
    IPR013766 Thioredoxin domain
    IPR012336 Thioredoxin-like fold
Molecular
Reagents
less
  • All nucleic 14
    cDNA 13
    Primer pair 1

    Microarray probesets 7
Other
Accession IDs
less
MGD-MRK-34252, MGI:1919415, MGI:1922285, MGI:2139068, MGI:2139273
References
more
  • Summaries
    All 30
    Developmental Gene Expression 1
    Diseases 2
    Gene Ontology 3
    Phenotypes 26
  • Earliest
    J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/20/2016
MGI 6.05 		The Jackson Laboratory