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Pnrc2 Gene Detail
Summary
  • Symbol
    Pnrc2
  • Name
    proline-rich nuclear receptor coactivator 2
  • Synonyms
    0610011E17Rik, D4Bwg0593e
  • Feature Type
    protein coding gene
  • IDs
    MGI:106512
    NCBI Gene: 52830
  • Gene Overview
    MyGene.info: PNRC2
Location & Maps
more
  • Sequence Map
    Chr4:135870918-135873850 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2933 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 68.01 cM, cytoband D3
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    PNRC2, proline rich nuclear receptor coactivator 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PNRC2, proline rich nuclear receptor coactivator 2
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 55629
    neXtProt AC: NX_Q9NPJ4

  • Chr Location
    1p36.11; chr1:23959811-23963462 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 9821
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PNRC2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 1 allele in 1 genetic background
    2 images
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    27
  • Chemically induced (other)
    2
  • Gene trapped
    21
  • Targeted
    4
  • Genomic Mutations
    3 involving Pnrc2
  • Incidental Mutations
Mice homozygous for a null allele exhibit decreased body weight, decreased percent body fat, resistance to diet-induced obesity, increased energy expenditure and increase heat production.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009795 VEGA Gene Model | MGI Sequence Detail 2933 C57BL/6J ±  kb
transcript OTTMUST00000022702 VEGA | MGI Sequence Detail 1919 Not Applicable  
polypeptide OTTMUSP00000010360 VEGA | MGI Sequence Detail 140 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    57 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000012952 proline-rich nuclear receptor coactivator 2
  • InterPro Domains
    IPR026780 Proline-rich nuclear receptor coactivator 1/2
    IPR026781 Proline-rich nuclear receptor coactivator 2
Molecular
Reagents
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  • All nucleic 186
    cDNA 185
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-34206, MGI:1915049
References
more
  • Summaries
    All 39
    Developmental Gene Expression 4
    Gene Ontology 3
    Phenotypes 9
  • Earliest
    J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
  • Latest
    J:193822 Lumayag S, et al., Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory