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Pnrc2 Gene Detail
Summary
  • Symbol
    Pnrc2
  • Name
    proline-rich nuclear receptor coactivator 2
  • Synonyms
    0610011E17Rik, D4Bwg0593e
  • Feature Type
    protein coding gene
  • IDs
    MGI:106512
    NCBI Gene: 52830
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:135598229-135601157 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 68.01 cM, cytoband D3
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    134 from dbSNP Build 142
  • Strain Annotations
    26
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106512
 protein coding gene Chr4:135598229-135601161 (-)
129S1/SvImJ ENSMUSG00200018414
 protein coding gene Chr4:129017972-129018102 (-)
129S1/SvImJ ENSMUSG00200018416
 protein coding gene Chr4:129018099-129018709 (-)
A/J ENSMUSG00195036268
 protein coding gene Chr4:130371713-130371843 (-)
A/J ENSMUSG00195036314
 protein coding gene Chr4:130371840-130372450 (-)
AKR/J ENSMUSG00220046379
 protein coding gene Chr4:129365092-129365702 (-)
AKR/J ENSMUSG00220046345
 protein coding gene Chr4:129364965-129365095 (-)
BALB/cJ ENSMUSG00180048877
 protein coding gene Chr4:128004174-128004304 (-)
BALB/cJ ENSMUSG00180048894
 protein coding gene Chr4:128004301-128004911 (-)
C3H/HeJ ENSMUSG00175045226
 protein coding gene Chr4:129024214-129024344 (-)
C3H/HeJ ENSMUSG00175045252
 protein coding gene Chr4:129024341-129024951 (-)
C57BL/6NJ ENSMUSG00215051780
 protein coding gene Chr4:130539574-130540184 (-)
C57BL/6NJ ENSMUSG00215051771
 protein coding gene Chr4:130539447-130539577 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026646
 protein coding gene Chr4:125540415-125543482 (-)
CAST/EiJ no annotation
CBA/J ENSMUSG00210052917
 protein coding gene Chr4:128648254-128648864 (-)
CBA/J ENSMUSG00210052916
 protein coding gene Chr4:128648127-128648257 (-)
DBA/2J ENSMUSG00185046453
 protein coding gene Chr4:130177500-130177630 (-)
DBA/2J ENSMUSG00185046486
 protein coding gene Chr4:130177627-130178237 (-)
FVB/NJ ENSMUSG00205036863
 protein coding gene Chr4:128420904-128421034 (-)
FVB/NJ ENSMUSG00205036918
 protein coding gene Chr4:128421031-128421641 (-)
JF1/MsJ no annotation
LP/J ENSMUSG00230037790
 protein coding gene Chr4:133956378-133956988 (-)
LP/J ENSMUSG00230037695
 protein coding gene Chr4:133954246-133956381 (-)
NOD/ShiLtJ ENSMUSG00190047768
 protein coding gene Chr4:128409776-128410386 (-)
NOD/ShiLtJ ENSMUSG00190047742
 protein coding gene Chr4:128409649-128409779 (-)
NZO/HlLtJ ENSMUSG00225026505
 protein coding gene Chr4:139911219-139911829 (-)
NZO/HlLtJ ENSMUSG00225026499
 protein coding gene Chr4:139909087-139911222 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    PNRC2, proline rich nuclear receptor coactivator 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PNRC2, proline rich nuclear receptor coactivator 2
  • Links
    NCBI Gene ID: 55629
    UniProt: Q9NPJ4

  • Chr Location
    1p36.11; chr1:23956839-23963776 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 1 allele in 1 genetic background
    2 images
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit decreased body weight, decreased percent body fat, resistance to diet-induced obesity, increased energy expenditure and increase heat production.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    678
  • Tissues
    24
  • cDNA Data
    186
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 52830 NCBI Gene Model | MGI Sequence Detail 2929 C57BL/6J ±  kb
    transcript NM_026383 RefSeq | MGI Sequence Detail 1907 ZRU/MplStud  
    polypeptide Q9CR73 UniProt | EBI | MGI Sequence Detail 140 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000012952 proline-rich nuclear receptor coactivator 2
      (term hierarchy)
    • InterPro Domains
      IPR026780 Proline-rich nuclear receptor coactivator 1/2
      IPR028322 Proline-rich nuclear receptor coactivator-like, proline rich region
    Molecular
    Reagents
    less
    • All nucleic 188
      cDNA 186
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-34206, MGI:1915049
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 5
      Gene Ontology 6
      Phenotypes 10
    • Earliest
      J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
    • Latest
      J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory