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Pnrc2
Gene Detail
Symbol

Name
ID
Pnrc2
proline-rich nuclear receptor coactivator 2
MGI:106512
Synonyms
0610011E17Rik, D4Bwg0593e
Feature Type
protein coding gene
Genetic Map
Chromosome 4
68.01 cM, cytoband D3
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr4:135870918-135873850 bp, - strand
From VEGA annotation of GRCm38

  2933 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9821  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PNRC2
Gene Tree: Pnrc2

Human
homologs
PNRC2, proline-rich nuclear receptor coactivator 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 55629
neXtProt AC: NX_Q9NPJ4

Human Chr (Location): 1p36.11; chr1:23959811-23963462 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(25) : Gene trapped(21) Targeted(4)
Genomic Mutations involving Pnrc2 (1)
Incidental mutations (data from CvDC )
 
Mice homozygous for a null allele exhibit decreased body weight, decreased percent body fat, resistance to diet-induced obesity, increased energy expenditure and increase heat production.
 
Phenotype Images(2)
Interactions
Pnrc2 interacts with 191 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (4 records)
Data Summary: Results (78)    Tissues (22)    Images (25)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 78
cDNA source data(185)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase pnrc2    NEW 
Molecular
reagents
All nucleic(186) cDNA(185) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000009795 (Evidence)
Ensembl Gene Model ENSMUSG00000028675 (Evidence)
Entrez Gene 52830 (Evidence)
UniGene 29159
DFCI TC1641030, TC1572334
DoTS DT.494568, DT.103563846, DT.101395023, DT.94366062
NIA Mouse Gene Index U025663
Consensus CDS Project CCDS18792.1
International Mouse Phenotyping Consortium Status Pnrc2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009795 VEGA Gene Model | MGI Sequence Detail 2933 C57BL/6J ±  kb
transcript OTTMUST00000022702 VEGA | MGI Sequence Detail 1919 Not Applicable 
polypeptide OTTMUSP00000010360 VEGA | MGI Sequence Detail 140 Not Applicable 

For the selected sequences
All sequences(58) RefSeq(6) UniProt(3)
Polymorphisms
SNPs within 2kb(57 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026780 Proline-rich nuclear receptor coactivator 1/2
InterPro IPR026781 Proline-rich nuclear receptor coactivator 2
Protein Ontology PR:000012952 proline-rich nuclear receptor coactivator 2
References
(Earliest) J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
(Latest) J:193822 Lumayag S, et al., Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16
All references(41)
Other
accession IDs
MGD-MRK-34206, MGI:1915049

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory