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Efhd2 Gene Detail
Summary
  • Symbol
    Efhd2
  • Name
    EF hand domain containing 2
  • Synonyms
    2600015J22Rik, D4Wsu27e, swiprosin 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:106504
    NCBI Gene: 27984
Location & Maps
more
  • Sequence Map
    Chr4:141858142-141874920 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      16779 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 74.75 cM, cytoband E1
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    EFHD2, EF-hand domain family member D2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    EFHD2, EF-hand domain family member D2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SWS1
  • Links
    NCBI Gene ID: 79180
    neXtProt AC: NX_Q96C19

  • Chr Location
    1p36.21; chr1:15409895-15430343 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 32580
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: EFHD2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    2
  • Targeted
    5
  • Genomic Mutations
    3 involving Efhd2
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit enhanced germinal center responses and humoral type 2 immunity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010040 VEGA Gene Model | MGI Sequence Detail 16779 C57BL/6J ±  kb
transcript OTTMUST00000023362 VEGA | MGI Sequence Detail 2381 Not Applicable  
polypeptide OTTMUSP00000010681 VEGA | MGI Sequence Detail 240 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    274 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 14
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-34198, MGI:1914390, MGI:2140132
References
more
  • Summaries
    All 38
    Developmental Gene Expression 4
    Gene Ontology 4
    Phenotypes 11
  • Earliest
    J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
  • Latest
    J:228565 Brachs S, et al., Swiprosin-1/EFhd2 limits germinal center responses and humoral type 2 immunity. Eur J Immunol. 2014 Nov;44(11):3206-19

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory