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Eif3b Gene Detail
Summary
  • Symbol
    Eif3b
  • Name
    eukaryotic translation initiation factor 3, subunit B
  • Synonyms
    D5Wsu45e, EIF3-P116, Eif3s9
  • Feature Type
    protein coding gene
  • IDs
    MGI:106478
    NCBI Gene: 27979
  • Gene Overview
    MyGene.info: EIF3B
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:140419328-140443360 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 78.97 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    42 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106478
protein coding gene Chr5:140419305-140443360 (.)
129S1/SvImJ MGP_129S1SvImJ_G0030299
protein coding gene Chr5:145485666-145513921 (+)
A/J MGP_AJ_G0030268
protein coding gene Chr5:139298904-139325582 (+)
AKR/J MGP_AKRJ_G0030200
protein coding gene Chr5:143653783-143676948 (+)
BALB/cJ MGP_BALBcJ_G0030285
protein coding gene Chr5:140539137-140562565 (+)
C3H/HeJ MGP_C3HHeJ_G0029996
protein coding gene Chr5:144428712-144453130 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030730
protein coding gene Chr5:150876837-150901802 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027948
protein coding gene Chr5:133143871-133167426 (+)
CAST/EiJ MGP_CASTEiJ_G0029401
protein coding gene Chr5:143855897-143878900 (+)
CBA/J MGP_CBAJ_G0029966
protein coding gene Chr5:157071705-157101077 (+)
DBA/2J MGP_DBA2J_G0030116
protein coding gene Chr5:139108354-139134110 (+)
FVB/NJ MGP_FVBNJ_G0030071
protein coding gene Chr5:138255879-138282519 (+)
LP/J MGP_LPJ_G0030202
protein coding gene Chr5:146097489-146127277 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030102
protein coding gene Chr5:159663603-159688887 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030770
protein coding gene Chr5:143486463-143512467 (+)
PWK/PhJ MGP_PWKPhJ_G0029116
protein coding gene Chr5:138130615-138154276 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028952
protein coding gene Chr5:141189245-141212103 (+)
WSB/EiJ MGP_WSBEiJ_G0029475
protein coding gene Chr5:144266979-144290310 (+)



Homology
more
  • Human Ortholog
    EIF3B, eukaryotic translation initiation factor 3 subunit B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    EIF3B, eukaryotic translation initiation factor 3 subunit B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EIF3-ETA, EIF3-P110, EIF3-P116, EIF3S9, PRT1
  • Links
    NCBI Gene ID: 8662
    neXtProt AC: NX_P55884
    UniProt: P55884

  • Chr Location
    7p22.3; chr7:2354540-2380745 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous embryos die prenatally prior to the blastocyst stage.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000056076 Ensembl Gene Model | MGI Sequence Detail 24033 C57BL/6J ±  kb
transcript ENSMUST00000100507 Ensembl | MGI Sequence Detail 2945 Not Applicable  
polypeptide ENSMUSP00000098076 Ensembl | MGI Sequence Detail 803 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000006974 eukaryotic translation initiation factor 3 subunit B
  • InterPro Domains
    IPR034363 eIF3B, RNA recognition motif
    IPR011400 Eukaryotic translation initiation factor 3 subunit B
    IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
    IPR035979 RNA-binding domain superfamily
    IPR000504 RNA recognition motif domain
    IPR013979 Translation initiation factor, beta propellor-like domain
    IPR015943 WD40/YVTN repeat-like-containing domain superfamily
Molecular
Reagents
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  • All nucleic 279
    cDNA 277
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-34172, MGI:2141022, MGI:2141024, MGI:2141170
References
more
  • Summaries
    All 41
    Developmental Gene Expression 2
    Gene Ontology 9
    Phenotypes 7
  • Earliest
    J:44426 Neidhardt LM, et al., A mouse gene of the paired-related homeobox class expressed in the caudal somite compartment and in the developing vertebral column, kidney and nervous system. Dev Genes Evol. 1997 OCT;207(5):330-339
  • Latest
    J:204915 Zeng L, et al., The m subunit of murine translation initiation factor eIF3 maintains the integrity of the eIF3 complex and is required for embryonic development, homeostasis, and organ size control. J Biol Chem. 2013 Oct 18;288(42):30087-93

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory