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Eif3b Gene Detail
Summary
  • Symbol
    Eif3b
  • Name
    eukaryotic translation initiation factor 3, subunit B
  • Synonyms
    D5Wsu45e, EIF3-P116, Eif3s9
  • Feature Type
    protein coding gene
  • IDs
    MGI:106478
    NCBI Gene: 27979
  • Gene Overview
    MyGene.info: EIF3B
Location & Maps
more
  • Sequence Map
    Chr5:140419328-140443360 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      24033 bp   ±  kb flank

  • Genome Browsers
Homology
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  • Human Ortholog
    EIF3B, eukaryotic translation initiation factor 3 subunit B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    EIF3B, eukaryotic translation initiation factor 3 subunit B
    Orthology source: HomoloGene
  • Synonyms
    EIF3-ETA, EIF3-P110, EIF3-P116, EIF3S9, PRT1
  • Links
    NCBI Gene ID: 8662
    neXtProt AC: NX_P55884

  • Chr Location
    7p22.3; chr7:2354540-2380745 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Homozygous embryos die prenatally prior to the blastocyst stage.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000054815 VEGA Gene Model | MGI Sequence Detail 24033 C57BL/6J ±  kb
transcript OTTMUST00000135834 VEGA | MGI Sequence Detail 2945 Not Applicable  
polypeptide OTTMUSP00000071809 VEGA | MGI Sequence Detail 803 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    42 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000006974 eukaryotic translation initiation factor 3 subunit B
  • InterPro Domains
    IPR011400 Eukaryotic translation initiation factor 3 subunit B
    IPR012677 Nucleotide-binding alpha-beta plait domain
    IPR000504 RNA recognition motif domain
    IPR011042 Six-bladed beta-propeller, TolB-like
    IPR013979 Translation initiation factor, beta propellor-like domain
    IPR015943 WD40/YVTN repeat-like-containing domain
Molecular
Reagents
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  • All nucleic 277
    cDNA 275
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-34172, MGI:2141022, MGI:2141024, MGI:2141170
References
more
  • Summaries
    All 37
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 7
  • Earliest
    J:44426 Neidhardt LM, et al., A mouse gene of the paired-related homeobox class expressed in the caudal somite compartment and in the developing vertebral column, kidney and nervous system. Dev Genes Evol. 1997 OCT;207(5):330-339
  • Latest
    J:204915 Zeng L, et al., The m subunit of murine translation initiation factor eIF3 maintains the integrity of the eIF3 complex and is required for embryonic development, homeostasis, and organ size control. J Biol Chem. 2013 Oct 18;288(42):30087-93

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory