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Vkorc1
Gene Detail
Symbol

Name
ID
Vkorc1
vitamin K epoxide reductase complex, subunit 1
MGI:106442
Synonyms
D7Wsu86e
Feature Type
protein coding gene
Genetic Map
Chromosome 7
69.81 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr7:127893067-127895617 bp, - strand
From VEGA annotation of GRCm38

  2551 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11416  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 zebrafish

HCOP human homology predictions: VKORC1
Protein SuperFamily: Vitamin K epoxide reductase complex subunit 1
Gene Tree: Vkorc1

Human
homologs
VKORC1, vitamin K epoxide reductase complex, subunit 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 79001
neXtProt AC: NX_Q9BQB6

Human Synonyms: EDTP308, IMAGE3455200, MST134, MST576, VKCFD2, VKOR

Human Chr (Location): 16p11.2; chr16:31090854-31096337 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human VKORC1

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Spontaneous(2) Targeted(1)
 
Spontaneous mutations of this gene have been associated with resistance to the anticoagulant effect of warfarin. Mice homozygous for a knock-out allele exhibit prenatal lethality and hemorrhages associated with defects in vitamin K-dependent coagulation.
 
Interactions
Vkorc1 interacts with 47 markers (Mir133a-1, Mir133a-2, Mir133b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process blood coagulation, bone development, ...
Component endoplasmic reticulum, integral component of membrane, ...
Function oxidoreductase activity, quinone binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (54)    Tissues (6)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 48
RT-PCR 6
cDNA source data(71)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN vkorc1    NEW 
Molecular
reagents
All nucleic(72) cDNA(71) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000031112 (Evidence)
Ensembl Gene Model ENSMUSG00000096145 (Evidence)
Entrez Gene 27973 (Evidence)
UniGene 29703
DFCI TC1576895
DoTS DT.97399761, DT.534352, DT.102549754, DT.101224836
NIA Mouse Gene Index U029312
EC 1.17.4.4
Consensus CDS Project CCDS21883.1
International Mouse Phenotyping Consortium Status Vkorc1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031112 VEGA Gene Model | MGI Sequence Detail 2551 C57BL/6J ±  kb
transcript OTTMUST00000077081 VEGA | MGI Sequence Detail 744 Not Applicable 
polypeptide OTTMUSP00000040668 VEGA | MGI Sequence Detail 161 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(32 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012932 Vitamin K epoxide reductase
Protein Ontology PR:000017303 vitamin K epoxide reductase complex subunit 1
References
(Earliest) J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(32)
Other
accession IDs
MGD-MRK-34136

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory