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Vkorc1 Gene Detail
Summary
  • Symbol
    Vkorc1
  • Name
    vitamin K epoxide reductase complex, subunit 1
  • Synonyms
    D7Wsu86e
  • Feature Type
    protein coding gene
  • IDs
    MGI:106442
    NCBI Gene: 27973
  • Gene Overview
    MyGene.info: VKORC1
Location & Maps
more
  • Sequence Map
    Chr7:127893063-127895617 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2555 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 69.81 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    VKORC1, vitamin K epoxide reductase complex subunit 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    VKORC1, vitamin K epoxide reductase complex subunit 1
    Orthology source: HomoloGene
  • Synonyms
    EDTP308, MST134, MST576, VKCFD2, VKOR
  • Links
    NCBI Gene ID: 79001
    neXtProt AC: NX_Q9BQB6

  • Chr Location
    16p11.2; chr16:31090854-31096337 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human VKORC1 associations

Human Disease Mouse Models
       Coumarin Resistance   OMIM: 122700
Vitamin K-Dependent Clotting Factors, Combined Deficiency of, 2; VKCFD2   OMIM: 607473
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 3 alleles in 3 genetic backgrounds
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Gene trapped
    1
  • Spontaneous
    2
  • Targeted
    1
Spontaneous mutations of this gene have been associated with resistance to the anticoagulant effect of warfarin. Mice homozygous for a knock-out allele exhibit prenatal lethality and hemorrhages associated with defects in vitamin K-dependent coagulation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031112 VEGA Gene Model | MGI Sequence Detail 2555 C57BL/6J ±  kb
transcript OTTMUST00000077081 VEGA | MGI Sequence Detail 748 Not Applicable  
polypeptide OTTMUSP00000040668 VEGA | MGI Sequence Detail 161 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    32 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000017303 vitamin K epoxide reductase complex subunit 1
  • EC
  • InterPro Domains
    IPR012932 Vitamin K epoxide reductase
Molecular
Reagents
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  • All nucleic 72
    cDNA 71
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-34136
References
more
  • Summaries
    All 29
    Developmental Gene Expression 2
    Gene Ontology 7
    Phenotypes 4
  • Earliest
    J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory