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Vkorc1 Gene Detail
Summary
  • Symbol
    Vkorc1
  • Name
    vitamin K epoxide reductase complex, subunit 1
  • Synonyms
    D7Wsu86e
  • Feature Type
    protein coding gene
  • IDs
    MGI:106442
    NCBI Gene: 27973
  • Gene Overview
    MyGene.info: VKORC1
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:127893063-127895617 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 69.81 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    32 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106442
protein coding gene Chr7:127893063-127895617 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033062
protein coding gene Chr7:132277644-132280198 (-)
A/J MGP_AJ_G0033045
protein coding gene Chr7:128738455-128741009 (-)
AKR/J MGP_AKRJ_G0032977
protein coding gene Chr7:132066017-132068571 (-)
BALB/cJ MGP_BALBcJ_G0033046
protein coding gene Chr7:128390207-128392761 (-)
C3H/HeJ MGP_C3HHeJ_G0032760
protein coding gene Chr7:131969510-131972059 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033555
protein coding gene Chr7:137424629-137427183 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030528
protein coding gene Chr7:129928312-129931163 (-)
CAST/EiJ MGP_CASTEiJ_G0032089
protein coding gene Chr7:123763605-123766219 (-)
CBA/J MGP_CBAJ_G0032733
protein coding gene Chr7:142095057-142097611 (-)
DBA/2J MGP_DBA2J_G0032885
protein coding gene Chr7:126714261-126716815 (-)
FVB/NJ MGP_FVBNJ_G0032838
protein coding gene Chr7:126576298-126578852 (-)
LP/J MGP_LPJ_G0032979
protein coding gene Chr7:133747493-133750047 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032870
protein coding gene Chr7:143164962-143167507 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033575
protein coding gene Chr7:131056013-131058567 (-)
PWK/PhJ MGP_PWKPhJ_G0031796
protein coding gene Chr7:119722270-119724872 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031642
protein coding gene Chr7:117867413-117870226 (-)
WSB/EiJ MGP_WSBEiJ_G0032201
protein coding gene Chr7:132022160-132024714 (-)



Homology
more
  • Human Ortholog
    VKORC1, vitamin K epoxide reductase complex subunit 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    VKORC1, vitamin K epoxide reductase complex subunit 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EDTP308, MST134, MST576, VKCFD2, VKOR
  • Links
    NCBI Gene ID: 79001
    neXtProt AC: NX_Q9BQB6
    UniProt: Q9BQB6

  • Chr Location
    16p11.2; chr16:31090842-31094999 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 5 alleles in 5 genetic backgrounds
    1 phenotype from multigenic genotypes
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Spontaneous mutations of this gene have been associated with resistance to the anticoagulant effect of warfarin. Mice homozygous for a knock-out allele exhibit prenatal lethality and hemorrhages associated with defects in vitamin K-dependent coagulation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 27973 NCBI Gene Model | MGI Sequence Detail 2555 C57BL/6J ±  kb
    transcript NM_178600 RefSeq | MGI Sequence Detail 764 Not Specified  
    polypeptide Q9CRC0 UniProt | EBI | MGI Sequence Detail 161 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 74
      cDNA 72
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-34136
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 6
    • Earliest
      J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
    • Latest
      J:262230 Lacombe J, et al., VKOR paralog VKORC1L1 supports vitamin K-dependent protein carboxylation in vivo. JCI Insight. 2018 Jan 11;3(1)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory