Vkorc1
Gene Detail

Symbol Name ID

Vkorc1 vitamin K epoxide reductase complex, subunit 1 MGI:106442

Synonyms

D7Wsu86e

Feature Type

protein coding gene

Genetic Map

Chromosome 7

69.81 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr7:127893067-127895617 bp, - strand From VEGA annotation of GRCm38   2551 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:11416  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: Vitamin K epoxide reductase complex subunit 1
Gene Tree: Vkorc1

Human homologs

Human Homolog		VKORC1, vitamin K epoxide reductase complex, subunit 1
NCBI Gene ID		79001
neXtProt AC		NX_Q9BQB6
Human Synonyms		EDTP308, IMAGE3455200, MST134, MST576, VKCFD2, VKOR
Human Chr (Location)		16p11.2; chr16:31102175-31106276 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human VKORC1

Alleles and phenotypes

All alleles(3) : Gene trapped(1) Spontaneous(2)
 

Spontaneous mutations of this gene have been associated with resistance to the anticoagulant effect of warfarin.

 

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	drug metabolic process, oxidation-reduction process, ...
Component	endoplasmic reticulum, integral to membrane, ...
Function	oxidoreductase activity, vitamin-K-epoxide reductase (warfarin-insensitive) activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (54)    Tissues (6)    Images (22)
Theiler Stages: 11, 23

Assay Type	Results
RNA in situ	48
RT-PCR	6

cDNA source data(71)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(72) cDNA(71) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000031112 (Evidence)
Ensembl Gene Model	ENSMUSG00000096145 (Evidence)
Entrez Gene	27973 (Evidence)
UniGene	29703
DFCI	TC1576895
DoTS	DT.101224836, DT.102549754, DT.534352, DT.97399761
NIA Mouse Gene Index	U029312
EC	1.1.4.1
Consensus CDS Project	CCDS21883.1
International Mouse Knockout Project Status	Vkorc1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000031112	VEGA Gene Model | MGI Sequence Detail	2551	C57BL/6J
transcript	OTTMUST00000077081	VEGA | MGI Sequence Detail	744	Not Applicable
polypeptide	OTTMUSP00000040668	VEGA | MGI Sequence Detail	161	Not Applicable

All sequences(32) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(22 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR012932	Vitamin K epoxide reductase
Protein Ontology	PR:000017303	vitamin K epoxide reductase complex subunit 1

References

(Earliest) J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(33)

Other accession IDs

MGD-MRK-34136