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Vkorc1
Gene Detail
 Symbol
Name
ID
Vkorc1
vitamin K epoxide reductase complex, subunit 1
MGI:106442
Synonyms D7Wsu86e
Feature Type protein coding gene
Genetic Map
Chromosome 7
69.81 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr7:127893067-127895617 bp, - strand
From VEGA annotation of GRCm38

  2551 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11416  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: Vitamin K epoxide reductase complex subunit 1
Gene Tree: Vkorc1

Human
homologs
Human Homolog VKORC1, vitamin K epoxide reductase complex, subunit 1
NCBI Gene ID 79001
neXtProt AC  NX_Q9BQB6
Human Synonyms  EDTP308, IMAGE3455200, MST134, MST576, VKCFD2, VKOR
Human Chr (Location)  16p11.2; chr16:31090854-31094955 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human VKORC1
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Spontaneous(2) Targeted(1)
 
Spontaneous mutations of this gene have been associated with resistance to the anticoagulant effect of warfarin. Mice homozygous for a knock-out allele exhibit prenatal lethality and hemorrhages associated with defects in vitamin K-dependent coagulation.
 
Interactions
Vkorc1 interacts with 47 markers (Mir133a-1, Mir133a-2, Mir133b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process blood coagulation, bone development, ...
Component endoplasmic reticulum, integral component of membrane, ...
Function oxidoreductase activity, quinone binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (54)    Tissues (6)    Images (22)
Theiler Stages: 11, 23
Assay TypeResults
RNA in situ 48
RT-PCR 6
cDNA source data(71)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(72) cDNA(71) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000031112 (Evidence)
Ensembl Gene ModelENSMUSG00000096145 (Evidence)
Entrez Gene27973 (Evidence)
UniGene29703
DFCITC1576895
DoTSDT.101224836, DT.102549754, DT.534352, DT.97399761
NIA Mouse Gene IndexU029312
EC1.1.4.1
Consensus CDS ProjectCCDS21883.1
International Mouse Knockout Project StatusVkorc1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031112 VEGA Gene Model | MGI Sequence Detail 2551 C57BL/6J ±  kb
transcript OTTMUST00000077081 VEGA | MGI Sequence Detail 744 Not Applicable 
polypeptide OTTMUSP00000040668 VEGA | MGI Sequence Detail 161 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(4) UniProt(2)
Polymorphisms SNPs within 2kb(32 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012932 Vitamin K epoxide reductase
Protein Ontology PR:000017303 vitamin K epoxide reductase complex subunit 1
References (Earliest) J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(34)
Other
accession IDs
MGD-MRK-34136

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory