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Ldhd Gene Detail
Summary
  • Symbol
    Ldhd
  • Name
    lactate dehydrogenase D
  • Synonyms
    4733401P21Rik, D8Bwg1320e
  • Feature Type
    protein coding gene
  • IDs
    MGI:106428
    NCBI Gene: 52815
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:112352250-112356968 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 57.98 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    208 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106428
 protein coding gene Chr8:112350417-112357006 (-)
129S1/SvImJ ENSMUSG00200012776
 protein coding gene Chr8:106651767-106675181 (-)
A/J ENSMUSG00195018665
 protein coding gene Chr8:106964408-106987824 (-)
AKR/J ENSMUSG00220015093
 protein coding gene Chr8:107106845-107130254 (-)
BALB/cJ ENSMUSG00180020099
 protein coding gene Chr8:106973722-106997497 (-)
C3H/HeJ ENSMUSG00175021750
 protein coding gene Chr8:107037201-107060608 (-)
C57BL/6NJ ENSMUSG00215016752
 protein coding gene Chr8:106629687-106653117 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031578
 protein coding gene Chr8:102723968-102730602 (-)
CAST/EiJ ENSTCUG00005032798
 protein coding gene Chr8:106389035-106412594 (-)
CBA/J ENSMUSG00210034946
 protein coding gene Chr8:106953760-106977175 (-)
DBA/2J ENSMUSG00185016578
 protein coding gene Chr8:113062915-113086317 (-)
FVB/NJ ENSMUSG00205022576
 protein coding gene Chr8:105966266-105989691 (-)
JF1/MsJ ENSUMUG00000014072
 protein coding gene Chr8:115396189-115419598 (-)
LP/J ENSMUSG00230029527
 protein coding gene Chr8:116742642-116766044 (-)
NOD/ShiLtJ ENSMUSG00190019293
 protein coding gene Chr8:107104747-107128169 (-)
NZO/HlLtJ ENSMUSG00225020674
 protein coding gene Chr8:120093366-120116780 (-)
PWK/PhJ ENSLUMG00010028192
 protein coding gene Chr8:106837307-106857502 (-)
SPRET/EiJ ENSMSPG00010033665
 protein coding gene Chr8:108957101-108966780 (-)
WSB/EiJ ENSIUOG00005029555
 protein coding gene Chr8:107801089-107824526 (-)



Homology
more
  • Human Ortholog
    LDHD, lactate dehydrogenase D
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LDHD, lactate dehydrogenase D
  • Synonyms
    DLACD
  • Links
    NCBI Gene ID: 197257
    UniProt: Q86WU2

  • Chr Location
    16q23.1; chr16:75111855-75116782 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    691
  • Tissues
    94
  • cDNA Data
    9
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 52815 NCBI Gene Model | MGI Sequence Detail 4719 C57BL/6J ±  kb
transcript NM_027570 RefSeq | MGI Sequence Detail 2888 C57BL/6  
polypeptide Q7TNG8 UniProt | EBI | MGI Sequence Detail 484 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 13
    cDNA 11
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-34122, MGI:1918086
References
more
  • Summaries
    All 39
    Developmental Gene Expression 1
    Gene Ontology 13
    Phenotypes 4
  • Earliest
    J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
  • Latest
    J:367058 Jin S, et al., Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis. Nat Commun. 2023 Oct 20;14(1):6638
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory