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Rtcb Gene Detail
Summary
  • Symbol
    Rtcb
  • Name
    RNA 2',3'-cyclic phosphate and 5'-OH ligase
  • Synonyms
    D10Wsu52e, HSPC117
  • Feature Type
    protein coding gene
  • IDs
    MGI:106379
    NCBI Gene: 28088
Location & Maps
more
  • Sequence Map
    Chr10:85938637-85957823 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      19187 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 41.81 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    RTCB, RNA 2',3'-cyclic phosphate and 5'-OH ligase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RTCB, RNA 2',3'-cyclic phosphate and 5'-OH ligase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C22orf28, DJ149A16.6, FAAP, HSPC117
  • Links
    NCBI Gene ID: 51493
    neXtProt AC: NX_Q9Y3I0

  • Chr Location
    22q12; chr22:32387575-32412287 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 36344
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: RTCB
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Targeted
    5
  • Genomic Mutations
    1 involving Rtcb
  • Incidental Mutations
Mice lacking expression in B cells show impaired immunoglobin secretion.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023233 VEGA Gene Model | MGI Sequence Detail 19187 C57BL/6J ±  kb
transcript OTTMUST00000056259 VEGA | MGI Sequence Detail 2009 Not Applicable  
polypeptide OTTMUSP00000027012 VEGA | MGI Sequence Detail 505 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    90 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000023892 RNA-splicing ligase RtcB
  • EC
  • InterPro Domains
    IPR001233 tRNA-splicing ligase, RtcB
    IPR027513 tRNA-splicing ligase RtcB homologue, eukaryotic
Molecular
Reagents
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  • All nucleic 241
    cDNA 240
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-34072, MGI:2143544, MGI:2143620
References
more
  • Summaries
    All 29
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 8
  • Earliest
    J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
  • Latest
    J:216740 Jurkin J, et al., The mammalian tRNA ligase complex mediates splicing of XBP1 mRNA and controls antibody secretion in plasma cells. EMBO J. 2014 Dec 17;33(24):2922-36

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory