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Rcor1 Gene Detail
Summary
  • Symbol
    Rcor1
  • Name
    REST corepressor 1
  • Synonyms
    6720480E22Rik, D12Wsu95e, mKIAA0071, Rocr1
  • Feature Type
    protein coding gene
  • IDs
    MGI:106340
    NCBI Gene: 217864
  • Gene Overview
    MyGene.info: RCOR1
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:111039351-111115901 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 60.93 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    238 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106340
protein coding gene Chr12:111038691-111115901 (.)
129S1/SvImJ MGP_129S1SvImJ_G0020126
protein coding gene Chr12:113396542-113478511 (+)
A/J MGP_AJ_G0020082
protein coding gene Chr12:109046140-109126418 (+)
AKR/J MGP_AKRJ_G0020057
protein coding gene Chr12:112169758-112247597 (+)
BALB/cJ MGP_BALBcJ_G0020067
protein coding gene Chr12:109462696-109542066 (+)
C3H/HeJ MGP_C3HHeJ_G0019869
protein coding gene Chr12:112641491-112723121 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020512
protein coding gene Chr12:116923292-117000134 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018125
protein coding gene Chr12:105494049-105568596 (+)
CAST/EiJ MGP_CASTEiJ_G0019410
protein coding gene Chr12:107526304-107606277 (+)
CBA/J MGP_CBAJ_G0019836
protein coding gene Chr12:121414667-121504066 (+)
DBA/2J MGP_DBA2J_G0019953
protein coding gene Chr12:108532625-108611663 (+)
FVB/NJ MGP_FVBNJ_G0019938
protein coding gene Chr12:107322037-107400820 (+)
LP/J MGP_LPJ_G0020028
protein coding gene Chr12:113210354-113283116 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019976
protein coding gene Chr12:124523737-124612594 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020541
protein coding gene Chr12:111660163-111752903 (+)
PWK/PhJ MGP_PWKPhJ_G0019171
protein coding gene Chr12:103159333-103240867 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018974
protein coding gene Chr12:105843443-105920740 (+)
WSB/EiJ MGP_WSBEiJ_G0019469
protein coding gene Chr12:112602152-112684278 (+)



Homology
more
  • Human Ortholog
    RCOR1, REST corepressor 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RCOR1, REST corepressor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    COREST, RCOR
  • Links
    NCBI Gene ID: 23186
    neXtProt AC: NX_Q9UKL0
    UniProt: Q9UKL0

  • Chr Location
    14q32.31-q32.32; chr14:102592638-102730576 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 32246
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: RCOR1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit partial embryonic lethality, defective embryonic erythropoiesis, and decreased erythroid progenitor cell number. No homozygotes survive to P7.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000037896 Ensembl Gene Model | MGI Sequence Detail 76551 C57BL/6J ±  kb
transcript ENSMUST00000084968 Ensembl | MGI Sequence Detail 5684 Not Applicable  
polypeptide ENSMUSP00000082034 Ensembl | MGI Sequence Detail 480 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 22
    cDNA 19
    Primer pair 3

    Microarray probesets 7
Other
Accession IDs
less
MGD-MRK-34032, MGI:2144964, MGI:2441723
References
more
  • Summaries
    All 56
    Developmental Gene Expression 10
    Gene Ontology 12
    Phenotypes 10
  • Earliest
    J:37953 Lan Y, et al., The Jagged2 gene maps to chromosome 12 and is a candidate for the lgl and sm mutations. Mamm Genome. 1997;8(11):875-6
  • Latest
    J:239534 Monaghan CE, et al., REST corepressors RCOR1 and RCOR2 and the repressor INSM1 regulate the proliferation-differentiation balance in the developing brain. Proc Natl Acad Sci U S A. 2017 Jan 17;114(3):E406-E415

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory