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Rcor1 Gene Detail
Summary
  • Symbol
    Rcor1
  • Name
    REST corepressor 1
  • Synonyms
    6720480E22Rik, D12Wsu95e, mKIAA0071, Rocr1
  • Feature Type
    protein coding gene
  • IDs
    MGI:106340
    NCBI Gene: 217864
Location & Maps
more
  • Sequence Map
    Chr12:111039351-111115901 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      76551 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    RCOR1, REST corepressor 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RCOR1, REST corepressor 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    COREST, RCOR
  • Links
    NCBI Gene ID: 23186
    neXtProt AC: NX_Q9UKL0

  • Chr Location
    14q32.31; chr14:102592639-102730576 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 32246
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: RCOR1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    26
  • Gene trapped
    21
  • Targeted
    5
  • Incidental Mutations
Mice homozygous for a null allele exhibit partial embryonic lethality, defective embryonic erythropoiesis, and decreased erythroid progenitor cell number. No homozygotes survive to P7.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029929 VEGA Gene Model | MGI Sequence Detail 76551 C57BL/6J ±  kb
transcript OTTMUST00000074256 VEGA | MGI Sequence Detail 5684 Not Applicable  
polypeptide OTTMUSP00000062788 VEGA | MGI Sequence Detail 480 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    238 from dbSNP Build 137
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 22
    cDNA 19
    Primer pair 3

    Microarray probesets 7
Other
Accession IDs
less
MGD-MRK-34032, MGI:2144964, MGI:2441723
References
more
  • Summaries
    All 49
    Developmental Gene Expression 9
    Gene Ontology 8
    Phenotypes 9
  • Earliest
    J:37953 Lan Y, et al., The Jagged2 gene maps to chromosome 12 and is a candidate for the lgl and sm mutations. Mamm Genome. 1997;8(11):875-6
  • Latest
    J:216215 Lee M, et al., p120-catenin regulates REST and CoREST, and modulates mouse embryonic stem cell differentiation. J Cell Sci. 2014 Sep 15;127(Pt 18):4037-51

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory