Foxred2 MGI Mouse Gene Detail - MGI:106315 - FAD-dependent oxidoreductase domain containing 2

Symbol

Foxred2
Name

FAD-dependent oxidoreductase domain containing 2
Synonyms

A430097D04Rik, D15Bwg0759e, LOC239554

Feature Type

protein coding gene
IDs

MGI:106315
NCBI Gene: 239554
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr15:77824722-77840922 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 36.92 cM
Mapping Data

3 experiments

SNPs within 2kb

1055 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_106315	protein coding gene	Chr15:77824722-77842701 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022033	protein coding gene	Chr15:78084547-78104079 (-)
A/J	MGP_AJ_G0021993	protein coding gene	Chr15:75371365-75388480 (-)
AKR/J	MGP_AKRJ_G0021970	protein coding gene	Chr15:77452071-77468327 (-)
BALB/cJ	MGP_BALBcJ_G0022001	protein coding gene	Chr15:75381891-75401444 (-)
C3H/HeJ	MGP_C3HHeJ_G0021772	protein coding gene	Chr15:77529708-77545834 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022443	protein coding gene	Chr15:81151510-81168942 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019972	protein coding gene	Chr15:71940259-71956445 (-)
CAST/EiJ	MGP_CASTEiJ_G0021292	protein coding gene	Chr15:78123667-78139776 (-)
CBA/J	MGP_CBAJ_G0021737	protein coding gene	Chr15:83662990-83684018 (-)
DBA/2J	MGP_DBA2J_G0021865	protein coding gene	Chr15:74869199-74885556 (-)
FVB/NJ	MGP_FVBNJ_G0021844	protein coding gene	Chr15:73858157-73874236 (-)
LP/J	MGP_LPJ_G0021934	protein coding gene	Chr15:78274093-78290297 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021864	protein coding gene	Chr15:88858177-88878782 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022457	protein coding gene	Chr15:77548053-77565564 (-)
PWK/PhJ	MGP_PWKPhJ_G0021034	protein coding gene	Chr15:74849068-74865346 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020870	protein coding gene	Chr15:77293297-77312140 (-)
WSB/EiJ	MGP_WSBEiJ_G0021345	protein coding gene	Chr15:77861242-77881193 (-)

Human Ortholog

FOXRED2, FAD dependent oxidoreductase domain containing 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FOXRED2, FAD dependent oxidoreductase domain containing 2
Synonyms

ERFAD
Links

HGNC:26264

NCBI Gene ID: 80020

UniProt: Q8IWF2
Chr Location

22q12.3; chr22:36487190-36507221 (-) GRCh38

MGI Vertebrate Homology

Foxred2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FOXRED2
Gene Tree

Foxred2

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References

1 with disease annotations

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
26 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

2
Endonuclease-mediated

2
Radiation induced

2
Targeted

2
Genomic Mutations

4 involving Foxred2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

28 strains or lines available

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All GO Annotations

16
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

716
Tissues

10
cDNA Data

46
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase foxred2

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All Sequences

51
RefSeq

11
UniProt

2
CCDS

CCDS27607.1

Ensembl

ENSMUSG00000016552 (Evidence)
NCBI Gene

239554

			Length	Strain/Species	Flank
genomic	ENSMUSG00000016552	Ensembl Gene Model \| MGI Sequence Detail	16201	C57BL/6J	± kb
transcript	ENSMUST00000117725	Ensembl \| MGI Sequence Detail	4347	Not Applicable
polypeptide	ENSMUSP00000113403	Ensembl \| MGI Sequence Detail	665	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000030713 FAD-dependent oxidoreductase domain-containing protein 2

(term hierarchy)
InterPro Domains

IPR050982 Auxin biosynthesis and cation transport

IPR036188 FAD/NAD(P)-binding domain superfamily
GlyGen

Q3USW5 4 sites, 3 N-linked glycans (4 sites)

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All nucleic 47

cDNA 46

Primer pair 1

Microarray probesets 2

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MGD-MRK-34007, MGI:2685150

Summaries

All 53

Developmental Gene Expression 1

Diseases 1

Gene Ontology 6

Phenotypes 26
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Foxred2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr135155	Chr15:77840858-77840923 (-)	31 bp
Tssr135154	Chr15:77840648-77840669 (-)	263 bp
Tssr135153	Chr15:77830072-77830094 (-)	10,839 bp
Tssr135152	Chr15:77829990-77830000 (-)	10,927 bp
Tssr135151	Chr15:77829965-77829980 (-)	10,949 bp
Tssr135150	Chr15:77829917-77829933 (-)	10,997 bp
Tssr4647	Chr15:77826322-77826326 (-)	14,598 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24