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Desi1 Gene Detail
Summary
  • Symbol
    Desi1
  • Name
    desumoylating isopeptidase 1
  • Synonyms
    D15Wsu75e, Fam152b, Pppde2
  • Feature Type
    protein coding gene
  • IDs
    MGI:106313
    NCBI Gene: 28075
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:81992523-82016220 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 38.34 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    118 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106313
protein coding gene Chr15:81992523-82033862 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022130
protein coding gene Chr15:82473423-82517042 (-)
A/J MGP_AJ_G0022091
protein coding gene Chr15:79557432-79598504 (-)
AKR/J MGP_AKRJ_G0022066
protein coding gene Chr15:81756483-81797488 (-)
BALB/cJ MGP_BALBcJ_G0022096
protein coding gene Chr15:79603367-79644675 (-)
C3H/HeJ MGP_C3HHeJ_G0021867
protein coding gene Chr15:81776937-81818821 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022539
protein coding gene Chr15:85709600-85751044 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020068
protein coding gene Chr15:75998816-76040734 (-)
CAST/EiJ MGP_CASTEiJ_G0021387
protein coding gene Chr15:82565927-82612733 (-)
CBA/J MGP_CBAJ_G0021832
protein coding gene Chr15:88381982-88422964 (-)
DBA/2J MGP_DBA2J_G0021961
protein coding gene Chr15:79030074-79071273 (-)
FVB/NJ MGP_FVBNJ_G0021938
protein coding gene Chr15:78077288-78118184 (-)
LP/J MGP_LPJ_G0022029
protein coding gene Chr15:82613887-82660764 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021959
protein coding gene Chr15:93306719-93347693 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022554
protein coding gene Chr15:81854868-81896666 (-)
PWK/PhJ MGP_PWKPhJ_G0021129
protein coding gene Chr15:79079761-79121768 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020968
protein coding gene Chr15:81651006-81697467 (-)
WSB/EiJ MGP_WSBEiJ_G0021439
protein coding gene Chr15:82286053-82326788 (-)



Homology
more
  • Human Ortholog
    DESI1, desumoylating isopeptidase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DESI1, desumoylating isopeptidase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    D15Wsu75e, DeSI-1, DESI2, DJ347H13.4, FAM152B, PPPDE2
  • Links
    NCBI Gene ID: 27351
    neXtProt AC: NX_Q6ICB0
    UniProt: Q6ICB0

  • Chr Location
    22q13.2; chr22:41598028-41621077 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 15891
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: DESI1
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotype references
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Radiation induced
    2
  • Targeted
    5
  • Genomic Mutations
    3 involving Desi1
  • Incidental Mutations
    APF , CvDC
  • Find Mice (IMSR)
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 28075 NCBI Gene Model | MGI Sequence Detail 23698 C57BL/6J ±  kb
transcript NM_134095 RefSeq | MGI Sequence Detail 2991 C57BL/6  
polypeptide Q9CQT7 UniProt | EBI | MGI Sequence Detail 168 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 123
    cDNA 122
    Primer pair 1

    Microarray probesets 8
Other
Accession IDs
less
MGD-MRK-34005, MGI:2146000, MGI:2146086
References
more
  • Summaries
    All 50
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 2
    Phenotypes 24
  • Earliest
    J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
  • Latest
    J:233611 Hirata A, et al., Homeobox family Hoxc localization during murine palate formation. Congenit Anom (Kyoto). 2016 Jul;56(4):172-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory