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Eif5a Gene Detail
Summary
  • Symbol
    Eif5a
  • Name
    eukaryotic translation initiation factor 5A
  • Synonyms
    D19Wsu54e
  • Feature Type
    protein coding gene
  • IDs
    MGI:106248
    NCBI Gene: 276770
  • Gene Overview
    MyGene.info: EIF5A
  • Alliance
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:69916714-69921958 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 42.92 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    42 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106248
protein coding gene Chr11:69916712-69921958 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018569
protein coding gene Chr11:70403652-70408904 (-)
A/J MGP_AJ_G0018537
protein coding gene Chr11:67738389-67743050 (-)
AKR/J MGP_AKRJ_G0018506
protein coding gene Chr11:69760746-69765289 (-)
BALB/cJ MGP_BALBcJ_G0018509
protein coding gene Chr11:68070900-68075046 (-)
C3H/HeJ MGP_C3HHeJ_G0018322
protein coding gene Chr11:69797306-69801846 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018960
protein coding gene Chr11:72529583-72534341 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016605
protein coding gene Chr11:64665441-64669527 (-)
CAST/EiJ MGP_CASTEiJ_G0017877
protein coding gene Chr11:70038035-70042060 (-)
CBA/J MGP_CBAJ_G0018294
protein coding gene Chr11:75778897-75783447 (-)
DBA/2J MGP_DBA2J_G0018404
protein coding gene Chr11:67324879-67328992 (-)
FVB/NJ MGP_FVBNJ_G0018394
protein coding gene Chr11:66965582-66970829 (-)
LP/J MGP_LPJ_G0018474
protein coding gene Chr11:70986415-70991671 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018417
protein coding gene Chr11:76373144-76380210 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019002
protein coding gene Chr11:70032836-70037082 (-)
PWK/PhJ MGP_PWKPhJ_G0017651
protein coding gene Chr11:67975373-67979828 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017441
protein coding gene Chr11:69841006-69845073 (-)
WSB/EiJ MGP_WSBEiJ_G0017931
protein coding gene Chr11:69695313-69699629 (-)



Homology
more
  • Human Ortholog
    EIF5A, eukaryotic translation initiation factor 5A
  • Vertebrate Orthologs
    9
  • Human Ortholog
    EIF5A, eukaryotic translation initiation factor 5A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EIF-5A, EIF5A1, eIF5AI
  • Links
    NCBI Gene ID: 1984
    neXtProt AC: NX_P63241
    UniProt: P63241

  • Chr Location
    17p13.1; chr17:7306999-7312463 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000078812 Ensembl Gene Model | MGI Sequence Detail 5245 C57BL/6J ±  kb
transcript ENSMUST00000108612 Ensembl | MGI Sequence Detail 1259 Not Applicable  
polypeptide ENSMUSP00000104252 Ensembl | MGI Sequence Detail 154 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000007003 eukaryotic translation initiation factor 5A-1
  • InterPro Domains
    IPR012340 Nucleic acid-binding, OB-fold
    IPR014722 Ribosomal protein L2, domain 2
    IPR020189 Translation elongation factor, IF5A C-terminal
    IPR019769 Translation elongation factor, IF5A, hypusine site
    IPR001884 Translation elongation factor IF5A-like
    IPR008991 Translation protein SH3-like domain superfamily
Molecular
Reagents
less
  • All nucleic 16
    cDNA 14
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-33940, MGI:2145157
References
more
  • Summaries
    All 52
    Developmental Gene Expression 6
    Gene Ontology 6
    Phenotypes 16
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:236582 Pallmann N, et al., Biological Relevance and Therapeutic Potential of the Hypusine Modification System. J Biol Chem. 2015 Jul 24;290(30):18343-60

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory