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Capza1 Gene Detail
Summary
  • Symbol
    Capza1
  • Name
    capping protein (actin filament) muscle Z-line, alpha 1
  • Synonyms
    Cappa1
  • Feature Type
    protein coding gene
  • IDs
    MGI:106227
    NCBI Gene: 12340
Location & Maps
more
  • Sequence Map
    Chr3:104822779-104864505 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      41727 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 45.88 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    CAPZA1, capping actin protein of muscle Z-line alpha subunit 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CAPZA1, capping actin protein of muscle Z-line alpha subunit 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CAPPA1, CAPZ, CAZ1
  • Links
    NCBI Gene ID: 829
    neXtProt AC: NX_P52907

  • Chr Location
    1p13.2; chr1:112619453-112671619 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotype references
  • All Mutations and Alleles
    48
  • Chemically induced (other)
    1
  • Gene trapped
    43
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Capza1
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022229 VEGA Gene Model | MGI Sequence Detail 41727 C57BL/6J ±  kb
transcript OTTMUST00000052870 VEGA | MGI Sequence Detail 3193 Not Applicable  
polypeptide OTTMUSP00000025120 VEGA | MGI Sequence Detail 286 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    282 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000005029 F-actin-capping protein subunit alpha-1
  • InterPro Domains
    IPR017865 F-actin capping protein, alpha subunit, conserved site
    IPR002189 F-actin-capping protein subunit alpha
Molecular
Reagents
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  • All nucleic 179
    Genomic 1
    cDNA 177
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-33919
References
more
  • Summaries
    All 33
    Developmental Gene Expression 3
    Gene Ontology 7
    Phenotypes 9
  • Earliest
    J:37796 Hart MC, et al., Mapping of the mouse actin capping protein alpha subunit genes and pseudogenes. Genomics. 1997 Feb 1;39(3):264-70
  • Latest
    J:208829 Fujiwara I, et al., Capping protein regulatory cycle driven by CARMIL and V-1 may promote actin network assembly at protruding edges. Proc Natl Acad Sci U S A. 2014 May 13;111(19):E1970-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory