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Cacna1e
Gene Detail
 Symbol
Name
ID
Cacna1e
calcium channel, voltage-dependent, R type, alpha 1E subunit
MGI:106217
Synonyms alpha1E, Cav2.3, Cchra1
Feature Type protein coding gene
Genetic Map
Chromosome 1
66.14 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr1:154392519-154725920 bp, - strand
From NCBI annotation of GRCm38

  333402 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20185  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: voltage-gated calcium channel
Gene Tree: Cacna1e

Human
homologs
Human Homolog CACNA1E, calcium channel, voltage-dependent, R type, alpha 1E subunit
NCBI Gene ID 777
neXtProt AC  NX_Q15878
Human Synonyms  BII, CACH6, CACNL1A6, Cav2.3
Human Chr (Location)  1q25.3; chr1:181483550-181806784 (+)  GRCh38
Alleles
and
phenotypes
All alleles(7) : Targeted(6) Gene trapped(1)
 
Homozygotes for targeted null mutations exhibit altered R-type Ca2+ channels, increased timidity and body weight, impaired glucose tolerance, reduced locomotor activity, and lack of the cocaine stimulation of locomotor response.
 
Gene Ontology
(GO)
classifications
All GO classifications: (50 annotations)
Process behavioral fear response, behavioral response to pain, ...
Component integral component of membrane, membrane, ...
Function calcium channel activity, calcium ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (131)    Tissues (26)    Images (24)
Theiler Stages: 15, 20, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 104
RT-PCR 27
cDNA source data(18)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(26) Genomic(2) cDNA(19) Primer pair(5)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000004110 (Evidence)
Entrez Gene12290 (Evidence)
UniGene267517
DFCITC1596799, TC1618669, TC1619737, TC1621723
DoTSDT.101347596, DT.40183817, DT.55193756, DT.91561091, DT.94169905
NIA Mouse Gene IndexU021910
International Mouse Knockout Project StatusCacna1e
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 12290 NCBI Gene Model | MGI Sequence Detail 333402 C57BL/6J ±  kb
transcript NM_009782 RefSeq | MGI Sequence Detail 12697 Not Specified 
polypeptide Q61290 UniProt | EBI | MGI Sequence Detail 2272 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(30) UniProt(3)
Polymorphisms All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs within 2kb(2354 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002048 EF-hand domain
InterPro IPR005821 Ion transport domain
InterPro IPR002077 Voltage-dependent calcium channel, alpha-1 subunit
InterPro IPR014873 Voltage-dependent calcium channel, alpha-1 subunit, IQ domain
InterPro IPR005449 Voltage-dependent calcium channel, R-type, alpha-1 subunit
InterPro IPR027359 Voltage-dependent potassium channel, four helix bundle domain
Protein Ontology PR:000002119 voltage-dependent R-type calcium channel subunit alpha-1E
Graphical View of Protein Domain Structure
References (Earliest) J:19970 Williams ME, et al., Structure and functional characterization of neuronal alpha 1E calcium channel subtypes. J Biol Chem. 1994 Sep 2;269(35):22347-57
(Latest) J:188270 Parajuli LK, et al., Quantitative Regional and Ultrastructural Localization of the Cav2.3 Subunit of R-type Calcium Channel in Mouse Brain. J Neurosci. 2012 Sep 26;32(39):13555-13567
All references(69)
Other
accession IDs
MGD-MRK-33909

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory