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Cacna1e
Gene Detail
Symbol

Name
ID
Cacna1e
calcium channel, voltage-dependent, R type, alpha 1E subunit
MGI:106217
Synonyms
alpha1E, Cav2.3, Cchra1
Feature Type
protein coding gene
Genetic Map
Chromosome 1
66.14 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr1:154390731-154884501 bp, - strand
From VEGA annotation of GRCm38

  493771 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20185  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: voltage-gated calcium channel
Gene Tree: Cacna1e

Human
homologs
Human Homolog CACNA1E, calcium channel, voltage-dependent, R type, alpha 1E subunit
NCBI Gene ID 777
neXtProt AC  NX_Q15878
Human Synonyms  BII, CACH6, CACNL1A6, Cav2.3
Human Chr (Location)  1q25.3; chr1:181483550-181806784 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit altered R-type Ca2+ channels, increased timidity and body weight, impaired glucose tolerance, reduced locomotor activity, and lack of the cocaine stimulation of locomotor response.
 
Interactions
Cacna1e interacts with 489 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (51 annotations)
Process behavioral fear response, behavioral response to pain, ...
Component integral component of membrane, membrane, ...
Function calcium channel activity, calcium ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (131)    Tissues (30)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 104
RT-PCR 27
cDNA source data(18)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(26) Genomic(2) cDNA(19) Primer pair(5)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000049818 (Evidence)
Ensembl Gene ModelENSMUSG00000004110 (Evidence)
Entrez Gene12290 (Evidence)
UniGene267517
DFCITC1621723, TC1619737, TC1596799, TC1618669
DoTSDT.101347596, DT.40183817, DT.94169905, DT.91561091, DT.55193756
NIA Mouse Gene IndexU021910
International Mouse Knockout Project StatusCacna1e
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049818 VEGA Gene Model | MGI Sequence Detail 493771 C57BL/6J ±  kb
transcript OTTMUST00000126873 VEGA | MGI Sequence Detail 14921 Not Applicable 
polypeptide OTTMUSP00000068577 VEGA | MGI Sequence Detail 2273 Not Applicable 

For the selected sequences
All sequences(65) RefSeq(30) UniProt(6)
Polymorphisms
All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs within 2kb(3622 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002048 EF-hand domain
InterPro IPR005821 Ion transport domain
InterPro IPR002077 Voltage-dependent calcium channel, alpha-1 subunit
InterPro IPR014873 Voltage-dependent calcium channel, alpha-1 subunit, IQ domain
InterPro IPR005449 Voltage-dependent calcium channel, R-type, alpha-1 subunit
InterPro IPR027359 Voltage-dependent potassium channel, four helix bundle domain
Protein Ontology PR:000002119 voltage-dependent R-type calcium channel subunit alpha-1E
References
(Earliest) J:19970 Williams ME, et al., Structure and functional characterization of neuronal alpha 1E calcium channel subtypes. J Biol Chem. 1994 Sep 2;269(35):22347-57
(Latest) J:206966 Etemad S, et al., Differential neuronal targeting of a new and two known calcium channel beta4 subunit splice variants correlates with their regulation of gene expression. J Neurosci. 2014 Jan 22;34(4):1446-61
All references(71)
Other
accession IDs
MGD-MRK-33909

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory