Cacna1e
Gene Detail

Symbol Name ID

Cacna1e calcium channel, voltage-dependent, R type, alpha 1E subunit MGI:106217

Synonyms

alpha1E, Cav2.3, Cchra1

Feature Type

protein coding gene

Genetic Map

Chromosome 1

66.14 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)

Sequence Map

Chr1:154392519-154725920 bp, - strand From NCBI annotation of GRCm38   333402 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20185  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: voltage-gated calcium channel
Gene Tree: Cacna1e

Human homologs

Human Homolog		CACNA1E, calcium channel, voltage-dependent, R type, alpha 1E subunit
NCBI Gene ID		777
neXtProt AC		NX_Q15878
Human Synonyms		BII, CACH6, CACNL1A6, Cav2.3
Human Chr (Location)		1q25.3; chr1:181452686-181775920 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(7) : Targeted(6) Gene trapped(1)
 

Homozygotes for targeted null mutations exhibit altered R-type Ca2+ channels, increased timidity and body weight, impaired glucose tolerance, reduced locomotor activity, and lack of the cocaine stimulation of locomotor response.

 

Gene Ontology (GO) classifications

All GO classifications: (46 annotations)

Process	behavioral fear response, behavioral response to pain, ...
Component	integral to membrane, membrane, ...
Function	calcium channel activity, calcium ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (131)    Tissues (26)    Images (24)
Theiler Stages: 15, 20, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	104
RT-PCR	27

cDNA source data(19)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(27) Genomic(2) cDNA(20) Primer pair(5)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000004110 (Evidence)
Entrez Gene	12290 (Evidence)
UniGene	267517
DFCI	TC1596799, TC1618669, TC1619737, TC1621723
DoTS	DT.101347596, DT.40183817, DT.55193756, DT.91561091, DT.94169905
NIA Mouse Gene Index	U021910
International Mouse Knockout Project Status	Cacna1e

Sequences

Length	Strain/Species
genomic	12290	NCBI Gene Model | MGI Sequence Detail	333402	C57BL/6J
transcript	NM_009782	RefSeq | MGI Sequence Detail	12697	Not Specified
polypeptide	Q61290	UniProt | EBI | MGI Sequence Detail	2272	Not Applicable

All sequences(27) RefSeq(2) UniProt(3)

Polymorphisms

All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs(1846 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002048	EF-hand domain
InterPro	IPR005821	Ion transport domain
InterPro	IPR002077	Voltage-dependent calcium channel, alpha-1 subunit
InterPro	IPR014873	Voltage-dependent calcium channel, alpha-1 subunit, IQ domain
InterPro	IPR005449	Voltage-dependent calcium channel, R-type, alpha-1 subunit
Protein Ontology	PR:000002119	voltage-dependent R-type calcium channel subunit alpha-1E

Graphical View of Protein Domain Structure

References

(Earliest) J:19970 Williams ME, et al., Structure and functional characterization of neuronal alpha 1E calcium channel subtypes. J Biol Chem. 1994 Sep 2;269(35):22347-57
(Latest) J:188270 Parajuli LK, et al., Quantitative Regional and Ultrastructural Localization of the Cav2.3 Subunit of R-type Calcium Channel in Mouse Brain. J Neurosci. 2012 Sep 26;32(39):13555-13567
All references(68)

Other accession IDs

MGD-MRK-33909