About   Help   FAQ
Aqp5
Gene Detail
Symbol

Name
ID
Aqp5
aquaporin 5
MGI:106215
Feature Type
protein coding gene
Genetic Map
Chromosome 15
56.13 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr15:99591028-99594829 bp, + strand
From NCBI annotation of GRCm38

  3802 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20398  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: aquaporin
Gene Tree: Aqp5

Human
homologs
Human Homolog AQP5, aquaporin 5
NCBI Gene ID 362
neXtProt AC  NX_P55064
Human Synonyms  AQP-5, PPKB
Human Chr (Location)  12q13; chr12:49961496-49965682 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Radiation induced(1) Targeted(3)
Genomic Mutations involving Aqp5 (1)
Incidental mutations (data from APF )
 
Homozygous null mutants exhibit reduced growth on solid food and secrete diminished amounts of hypertonic, viscous saliva.
 
Interactions
Aqp5 interacts with 66 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process camera-type eye morphogenesis, carbon dioxide transport, ...
Component apical plasma membrane, basal plasma membrane, ...
Function protein binding, transporter activity, ...
External Resources: FuncBase
Expression
Literature Summary: (72 records)
Data Summary: Results (120)    Tissues (71)    Images (17)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 6
RNA in situ 55
Northern blot 12
Western blot 15
RT-PCR 32
cDNA source data(96)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(108) Genomic(2) cDNA(97) Primer pair(7) Other(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000044217 (Evidence)
Entrez Gene11830 (Evidence)
UniGene45580
DFCITC1579080, TC1601617
DoTSDT.101208518, DT.522693
NIA Mouse Gene IndexU016644
Consensus CDS ProjectCCDS27823.1
International Mouse Knockout Project StatusAqp5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 11830 NCBI Gene Model | MGI Sequence Detail 3802 C57BL/6J ±  kb
transcript NM_009701 RefSeq | MGI Sequence Detail 1551 C57BL/6 
polypeptide Q9WTY4 UniProt | EBI | MGI Sequence Detail 265 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(27 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023276 Aquaporin 5
InterPro IPR023271 Aquaporin-like
InterPro IPR000425 Major intrinsic protein
InterPro IPR022357 Major intrinsic protein, conserved site
Protein Ontology PR:000004185 aquaporin-5
Graphical View of Protein Domain Structure
References
(Earliest) J:34248 Steinman RM, et al., Dendritic cells are the principal stimulators of the primary mixed leukocyte reaction in mice. J Exp Med. 1983 Feb 1;157(2):613-27
(Latest) J:206750 Whiteman EL, et al., Crumbs3 is essential for proper epithelial development and viability. Mol Cell Biol. 2014 Jan;34(1):43-56
All references(135)
Other
accession IDs
MGD-MRK-33907

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/08/2014
MGI 5.20
The Jackson Laboratory