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Aqp5 Gene Detail
Summary
  • Symbol
    Aqp5
  • Name
    aquaporin 5
  • Feature Type
    protein coding gene
  • IDs
    MGI:106215
    NCBI Gene: 11830
  • Gene Overview
    MyGene.info: AQP5
Location & Maps
more
  • Sequence Map
    Chr15:99591028-99594829 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3802 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    AQP5, aquaporin 5
  • Vertebrate Orthologs
    9
  • Human Ortholog
    AQP5, aquaporin 5
    Orthology source: HomoloGene
  • Synonyms
    AQP-5, PPKB
  • Links
    NCBI Gene ID: 362
    neXtProt AC: NX_P55064

  • Chr Location
    12q13; chr12:49961496-49965682 (+)  GRCh38.p2

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 2 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    49 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Radiation induced
    2
  • Targeted
    3
  • Genomic Mutations
    3 involving Aqp5
  • Incidental Mutations
    APF
Homozygous null mutants exhibit reduced growth on solid food and secrete diminished amounts of hypertonic, viscous saliva.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 11830 NCBI Gene Model | MGI Sequence Detail 3802 C57BL/6J ±  kb
transcript NM_009701 RefSeq | MGI Sequence Detail 1551 C57BL/6  
polypeptide Q9WTY4 UniProt | EBI | MGI Sequence Detail 265 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    27 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
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  • All nucleic 111
    Genomic 2
    cDNA 97
    Primer pair 10
    Other 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-33907
References
more
  • Summaries
    All 149
    Developmental Gene Expression 84
    Diseases 1
    Gene Ontology 15
    Phenotypes 49
  • Earliest
    J:32428 Lee MD, et al., The human Aquaporin-5 gene. Molecular characterization and chromosomal localization. J Biol Chem. 1996 Apr 12;271(15):8599-604
  • Latest
    J:230267 Petrova RS, et al., Spatial distributions of AQP5 and AQP0 in embryonic and postnatal mouse lens development. Exp Eye Res. 2015 Mar;132:124-35

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory