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Aqp5 Gene Detail
Summary
  • Symbol
    Aqp5
  • Name
    aquaporin 5
  • Feature Type
    protein coding gene
  • IDs
    MGI:106215
    NCBI Gene: 11830
  • Gene Overview
    MyGene.info: AQP5
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr15:99591028-99594829 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3802 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 56.13 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    AQP5, aquaporin 5
  • Vertebrate Orthologs
    9
  • Human Ortholog
    AQP5, aquaporin 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AQP-5, PPKB
  • Links
    NCBI Gene ID: 362
    neXtProt AC: NX_P55064
    UniProt: P55064

  • Chr Location
    12q13.12; chr12:49961496-49965682 (+)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 2 alleles in 3 genetic backgrounds
    4 phenotypes from multigenic genotypes
    53 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants exhibit reduced growth on solid food and secrete diminished amounts of hypertonic, viscous saliva.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11830 NCBI Gene Model | MGI Sequence Detail 3802 C57BL/6J ±  kb
    transcript NM_009701 RefSeq | MGI Sequence Detail 1551 C57BL/6  
    polypeptide Q9WTY4 UniProt | EBI | MGI Sequence Detail 265 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      27 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 112
      Genomic 2
      cDNA 98
      Primer pair 10
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-33907
    References
    more
    • Summaries
      All 202
      Developmental Gene Expression 108
      Diseases 1
      Gene Ontology 15
      Phenotypes 53
    • Earliest
      J:34248 Steinman RM, et al., Dendritic cells are the principal stimulators of the primary mixed leukocyte reaction in mice. J Exp Med. 1983 Feb 1;157(2):613-27
    • Latest
      J:258246 Hosseini ZF, et al., FGF2-dependent mesenchyme and laminin-111 are niche factors in salivary gland organoids. J Cell Sci. 2018 Feb 20;131(4)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    07/10/2018
    MGI 6.12
    The Jackson Laboratory