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Aqp5
Gene Detail
Symbol

Name
ID
Aqp5
aquaporin 5
MGI:106215
Feature Type
protein coding gene
Genetic Map
Chromosome 15
56.13 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr15:99591028-99594829 bp, + strand
From NCBI annotation of GRCm38

  3802 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20398  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: AQP5
Protein SuperFamily: aquaporin
Gene Tree: Aqp5

Human
homologs
AQP5, aquaporin 5
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 362
neXtProt AC: NX_P55064

Human Synonyms: AQP-5, PPKB

Human Chr (Location): 12q13; chr12:49961496-49965682 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Radiation induced(1) Targeted(3)
Genomic Mutations involving Aqp5 (1)
Incidental mutations (data from APF )
 
Homozygous null mutants exhibit reduced growth on solid food and secrete diminished amounts of hypertonic, viscous saliva.
 
Phenotype Images(2)
Interactions
Aqp5 interacts with 65 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process camera-type eye morphogenesis, carbohydrate transmembrane transport, ...
Component apical plasma membrane, basal plasma membrane, ...
Function glycerol channel activity, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (80 records)
Data Summary: Results (121)    Tissues (72)    Images (18)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 6
RNA in situ 55
Northern blot 12
Western blot 15
RT-PCR 33
cDNA source data(96)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(109) Genomic(2) cDNA(97) Primer pair(8) Other(2)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000044217 (Evidence)
Entrez Gene 11830 (Evidence)
UniGene 45580
DFCI TC1579080, TC1601617
DoTS DT.101208518, DT.522693
NIA Mouse Gene Index U016644
Consensus CDS Project CCDS27823.1
International Mouse Phenotyping Consortium Status Aqp5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 11830 NCBI Gene Model | MGI Sequence Detail 3802 C57BL/6J ±  kb
transcript NM_009701 RefSeq | MGI Sequence Detail 1551 C57BL/6 
polypeptide Q9WTY4 UniProt | EBI | MGI Sequence Detail 265 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(27 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023276 Aquaporin 5
InterPro IPR023271 Aquaporin-like
InterPro IPR000425 Major intrinsic protein
InterPro IPR022357 Major intrinsic protein, conserved site
Protein Ontology PR:000004185 aquaporin-5
Graphical View of Protein Domain Structure
References
(Earliest) J:32428 Lee MD, et al., The human Aquaporin-5 gene. Molecular characterization and chromosomal localization. J Biol Chem. 1996 Apr 12;271(15):8599-604
(Latest) J:222176 Pena-Munzenmayer G, et al., Ae4 (Slc4a9) Anion Exchanger Drives Cl- Uptake-dependent Fluid Secretion by Mouse Submandibular Gland Acinar Cells. J Biol Chem. 2015 Apr 24;290(17):10677-88
All references(144)
Other
accession IDs
MGD-MRK-33907

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory