Dmbt1
Gene Detail

Symbol Name ID

Dmbt1 deleted in malignant brain tumors 1 MGI:106210

Synonyms

CRP-[a], CRP-[b], Crpd, ebnerin, gp300, hensin, MUCLIN, vomeroglandin

Feature Type

protein coding gene

Genetic Map

Chromosome 7

73.20 cM, cytoband F4
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr7:131032076-131121626 bp, + strand From Ensembl annotation of GRCm38   89551 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68990  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Dmbt1

Human homologs

Human Homolog		DMBT1, deleted in malignant brain tumors 1
NCBI Gene ID		1755
neXtProt AC		NX_Q9UGM3
Human Synonyms		GP340, muclin
Human Chr (Location)		10q26.13; chr10:124320181-124403252 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(6) : Targeted(6)
 

Mice homozygous for one null allele display embryonic lethality and an abnormal inner cell mass. Mice homozygous for a different null allele are viable and fertile with an increased susceptibility to induced colitis.

 

Gene Ontology (GO) classifications

All GO classifications: (24 annotations)

Process	blastocyst development, cell differentiation, ...
Component	cytoplasm, cytoplasmic vesicle, ...
Function	Gram-negative bacterial cell surface binding, Gram-positive bacterial cell surface binding, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (66)    Tissues (41)    Images (19)
Theiler Stages: 10, 18, 19, 23, 25, 28

Assay Type	Results
RNA in situ	46
Northern blot	12
Western blot	8

cDNA source data(85)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(87) Genomic(2) cDNA(85)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000047517 (Evidence)
Entrez Gene	12945 (Evidence)
UniGene	4138
DFCI	TC1575669
DoTS	DT.101308688, DT.101376104, DT.533024
NIA Mouse Gene Index	U040689
Consensus CDS Project	CCDS21909.1
International Mouse Knockout Project Status	Dmbt1

Sequences

Length	Strain/Species
genomic	ENSMUSG00000047517	Ensembl Gene Model | MGI Sequence Detail	89551	C57BL/6J
transcript	ENSMUST00000084509	Ensembl | MGI Sequence Detail	6241	Not Applicable
polypeptide	ENSMUSP00000081556	Ensembl | MGI Sequence Detail	1946	Not Applicable

All sequences(28) RefSeq(3) UniProt(3)

Polymorphisms

SNPs(439 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000859	CUB
InterPro	IPR001190	Speract/scavenger receptor
InterPro	IPR017448	Speract/scavenger receptor-related
InterPro	IPR001507	Zona pellucida domain
InterPro	IPR017977	Zona pellucida domain, conserved site
Protein Ontology	PR:000006534	deleted in malignant brain tumors 1 protein

References

(Earliest) J:150701 De Lisle RC, Characterization of the major sulfated protein of mouse pancreatic acinar cells: a high molecular weight peripheral membrane glycoprotein of zymogen granules. J Cell Biochem. 1994 Nov;56(3):385-96
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(41)

Other accession IDs

MGD-MRK-33902