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Dmbt1
Gene Detail
Symbol

Name
ID
Dmbt1
deleted in malignant brain tumors 1
MGI:106210
Synonyms
CRP-[a], CRP-[b], Crpd, ebnerin, gp300, hensin, MUCLIN, vomeroglandin
Feature Type
protein coding gene
Genetic Map
Chromosome 7
73.20 cM, cytoband F4
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:131032076-131121626 bp, + strand
From Ensembl annotation of GRCm38

  89551 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68990  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Dmbt1

Human
homologs
Human Homolog DMBT1, deleted in malignant brain tumors 1
NCBI Gene ID 1755
neXtProt AC  NX_Q9UGM3
Human Synonyms  GP340, muclin
Human Chr (Location)  10q26.13; chr10:122560665-122643736 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for one null allele display embryonic lethality and an abnormal inner cell mass. Mice homozygous for a different null allele are viable and fertile with an increased susceptibility to induced colitis.
 
Interactions
Dmbt1 interacts with 109 markers (Mir16-1, Mir17, Mir20b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process blastocyst development, cell differentiation, ...
Component cytoplasm, cytoplasmic vesicle, ...
Function protein binding, scavenger receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (66)    Tissues (41)    Images (19)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 46
Northern blot 12
Western blot 8
cDNA source data(85)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(87) Genomic(2) cDNA(85)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000047517 (Evidence)
Entrez Gene12945 (Evidence)
UniGene4138
DFCITC1575669
DoTSDT.101308688, DT.101376104, DT.533024
NIA Mouse Gene IndexU040689
Consensus CDS ProjectCCDS21909.1
International Mouse Knockout Project StatusDmbt1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000047517 Ensembl Gene Model | MGI Sequence Detail 89551 C57BL/6J ±  kb
transcript ENSMUST00000084509 Ensembl | MGI Sequence Detail 6241 Not Applicable 
polypeptide ENSMUSP00000081556 Ensembl | MGI Sequence Detail 1946 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(23) UniProt(3)
Polymorphisms
SNPs within 2kb(643 from dbSNP Build 137)    SNPs within 2kb including multiple locations(663)
Protein-related
information
ResourceIDDescription
InterPro IPR000859 CUB domain
InterPro IPR001190 Speract/scavenger receptor
InterPro IPR017448 Speract/scavenger receptor-related
InterPro IPR001507 Zona pellucida domain
InterPro IPR017977 Zona pellucida domain, conserved site
Protein Ontology PR:000006534 deleted in malignant brain tumors 1 protein
References
(Earliest) J:150701 De Lisle RC, Characterization of the major sulfated protein of mouse pancreatic acinar cells: a high molecular weight peripheral membrane glycoprotein of zymogen granules. J Cell Biochem. 1994 Nov;56(3):385-96
(Latest) J:195611 Muller H, et al., Deleted in malignant brain tumors 1 is present in the vascular extracellular matrix and promotes angiogenesis. Arterioscler Thromb Vasc Biol. 2012 Feb;32(2):442-8
All references(42)
Other
accession IDs
MGD-MRK-33902

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory