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Dmbt1 Gene Detail
Summary
  • Symbol
    Dmbt1
  • Name
    deleted in malignant brain tumors 1
  • Synonyms
    CRP-[a], CRP-[b], Crpd, ebnerin, gp300, hensin, MUCLIN, vomeroglandin
  • Feature Type
    protein coding gene
  • IDs
    MGI:106210
    NCBI Gene: 12945
  • Gene Overview
    MyGene.info: DMBT1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr7:131032053-131121630 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      89578 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 73.20 cM, cytoband F4
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    DMBT1, deleted in malignant brain tumors 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    DMBT1, deleted in malignant brain tumors 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GP340, muclin, SAG, SALSA
  • Links
    NCBI Gene ID: 1755
    neXtProt AC: NX_Q9UGM3
    UniProt: Q9UGM3

  • Chr Location
    10q26.13; chr10:122560665-122643736 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 4 alleles in 6 genetic backgrounds
    2 phenotypes from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one null allele display embryonic lethality and an abnormal inner cell mass. Mice homozygous for a different null allele are viable and fertile with an increased susceptibility to induced colitis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000059749 VEGA Gene Model | MGI Sequence Detail 89578 C57BL/6J ±  kb
    transcript OTTMUST00000146510 VEGA | MGI Sequence Detail 6272 Not Applicable  
    polypeptide OTTMUSP00000076268 VEGA | MGI Sequence Detail 1957 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      631 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 88
      Genomic 2
      cDNA 86

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-33902
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 6
      Gene Ontology 10
      Phenotypes 9
    • Earliest
      J:150701 De Lisle RC, Characterization of the major sulfated protein of mouse pancreatic acinar cells: a high molecular weight peripheral membrane glycoprotein of zymogen granules. J Cell Biochem. 1994 Nov;56(3):385-96
    • Latest
      J:195611 Muller H, et al., Deleted in malignant brain tumors 1 is present in the vascular extracellular matrix and promotes angiogenesis. Arterioscler Thromb Vasc Biol. 2012 Feb;32(2):442-8

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    07/10/2018
    MGI 6.12
    The Jackson Laboratory