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Mnat1
Gene Detail
 Symbol
Name
ID
Mnat1
menage a trois 1
MGI:106207
Synonyms E130115E11Rik, MAT1
Feature Type protein coding gene
Genetic Map
Chromosome 12
30.37 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr12:73123717-73273988 bp, + strand
From NCBI annotation of GRCm38

  150272 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1821  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: CDK-activating kinase assembly factor MAT1
Gene Tree: Mnat1

Human
homologs
Human Homolog MNAT1, MNAT CDK-activating kinase assembly factor 1
NCBI Gene ID 4331
neXtProt AC  NX_P51948
Human Synonyms  CAP35, MAT1, RNF66, TFB3
Human Chr (Location)  14q23; chr14:60734741-60968680 (+)  GRCh38
Alleles
and
phenotypes
All alleles(24) : Gene trapped(20) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruption of this gene die as embryos at some point between implantation and gastrulation.
 
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process adult heart development, ATP catabolic process, ...
Component cytoplasm, holo TFIIH complex, ...
Function DNA-dependent ATPase activity, metal ion binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (56)    Tissues (49)    Images (1)
Theiler Stages: 3, 4, 5, 19, 23, 28
Assay TypeResults
Immunohistochemistry 9
RNA in situ 1
RT-PCR 46
cDNA source data(66)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(73) cDNA(72) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000021103 (Evidence)
Entrez Gene17420 (Evidence)
UniGene246750
DFCITC1576962, TC1599624
DoTSDT.532347, DT.97406830
NIA Mouse Gene IndexU014074
Consensus CDS ProjectCCDS49087.1
International Mouse Knockout Project StatusMnat1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 17420 NCBI Gene Model | MGI Sequence Detail 150272 C57BL/6J ±  kb
transcript NM_008612 RefSeq | MGI Sequence Detail 2505 C57BL/6 
polypeptide P51949 UniProt | EBI | MGI Sequence Detail 309 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(4) UniProt(2)
Polymorphisms SNPs within 2kb(819 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015877 Cdk-activating kinase assembly factor MAT1, centre
InterPro IPR004575 Cdk-activating kinase assembly factor MAT1/Tfb3
InterPro IPR003903 Ubiquitin interacting motif
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR001841 Zinc finger, RING-type
InterPro IPR017907 Zinc finger, RING-type, conserved site
Protein Ontology PR:000010496 CDK-activating kinase assembly factor MAT1
Graphical View of Protein Domain Structure
References (Earliest) J:29185 Fisher RP, et al., Alternative mechanisms of CAK assembly require an assembly factor or an activating kinase. Cell. 1995 Oct 6;83(1):47-57
(Latest) J:173837 Helenius K, et al., Requirement of TFIIH kinase subunit Mat1 for RNA Pol II C-terminal domain Ser5 phosphorylation, transcription and mRNA turnover. Nucleic Acids Res. 2011 Jul 1;39(12):5025-35
All references(42)
Other
accession IDs
MGD-MRK-33899, MGI:2445133

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory