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Mnat1
Gene Detail
Symbol

Name
ID
Mnat1
menage a trois 1
MGI:106207
Synonyms
E130115E11Rik, MAT1
Feature Type
protein coding gene
Genetic Map
Chromosome 12
30.37 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr12:73123717-73273988 bp, + strand
From VEGA annotation of GRCm38

  150272 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1821  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MNAT1
Protein SuperFamily: CDK-activating kinase assembly factor MAT1
Gene Tree: Mnat1

Human
homologs
MNAT1, MNAT CDK-activating kinase assembly factor 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4331
neXtProt AC: NX_P51948

Human Synonyms: CAP35, MAT1, RNF66, TFB3

Human Chr (Location): 14q23; chr14:60734741-60968680 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(24) : Gene trapped(20) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruption of this gene die as embryos at some point between implantation and gastrulation.
 
Interactions
Mnat1 interacts with 248 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process adult heart development, cell cycle, ...
Component cytoplasm, holo TFIIH complex, ...
Function DNA-dependent ATPase activity, metal ion binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (56)    Tissues (49)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 9
RNA in situ 1
RT-PCR 46
cDNA source data(66)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase mnat1 ; ZFIN mnat1    NEW 
Molecular
reagents
All nucleic(73) cDNA(72) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000047017 (Evidence)
Ensembl Gene Model ENSMUSG00000021103 (Evidence)
Entrez Gene 17420 (Evidence)
UniGene 246750
DFCI TC1576962, TC1599624
DoTS DT.532347, DT.97406830
NIA Mouse Gene Index U014074
Consensus CDS Project CCDS49087.1
International Mouse Phenotyping Consortium Status Mnat1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000047017 VEGA Gene Model | MGI Sequence Detail 150272 C57BL/6J ±  kb
transcript OTTMUST00000121788 VEGA | MGI Sequence Detail 2505 Not Applicable 
polypeptide OTTMUSP00000067003 VEGA | MGI Sequence Detail 309 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(6) UniProt(4)
Polymorphisms
SNPs within 2kb(819 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015877 Cdk-activating kinase assembly factor MAT1, centre
InterPro IPR004575 Cdk-activating kinase assembly factor MAT1/Tfb3
InterPro IPR003903 Ubiquitin interacting motif
InterPro IPR018957 Zinc finger, C3HC4 RING-type
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR001841 Zinc finger, RING-type
InterPro IPR017907 Zinc finger, RING-type, conserved site
Protein Ontology PR:000010496 CDK-activating kinase assembly factor MAT1
References
(Earliest) J:29185 Fisher RP, et al., Alternative mechanisms of CAK assembly require an assembly factor or an activating kinase. Cell. 1995 Oct 6;83(1):47-57
(Latest) J:173837 Helenius K, et al., Requirement of TFIIH kinase subunit Mat1 for RNA Pol II C-terminal domain Ser5 phosphorylation, transcription and mRNA turnover. Nucleic Acids Res. 2011 Jul 1;39(12):5025-35
All references(43)
Other
accession IDs
MGD-MRK-33899, MGI:2445133

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory