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Skil
Gene Detail
Symbol

Name
ID
Skil
SKI-like
MGI:106203
Synonyms
9130011J04Rik, Skir, sno-dE3, SnoN, SnoN2
Feature Type
protein coding gene
Genetic Map
Chromosome 3
15.12 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr3:31095058-31122577 bp, + strand
From VEGA annotation of GRCm38

  27520 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3948  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: ski transforming protein
Gene Tree: Skil

Human
homologs
Human Homolog SKIL, SKI-like proto-oncogene
NCBI Gene ID 6498
neXtProt AC  NX_P12757
Human Synonyms  SNO, SnoA, SnoI, SnoN
Human Chr (Location)  3q26; chr3:170357678-170396849 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(48) : Gene trapped(42) Targeted(6)
 
Mice which carry at least one allele for a disruption in this gene display abnomalities in their lymphocytes. Results with respect to embryonic lethality are inconsistent among the various allelic disruptions of this gene.
 
Interactions
Skil interacts with 415 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (35 annotations)
Process blastocyst formation, cell cycle arrest, ...
Component acrosomal vesicle, cytoplasm, ...
Function chromatin binding, protein binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (101)    Tissues (66)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 67
Northern blot 10
Western blot 4
RT-PCR 20
cDNA source data(22)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(32) Genomic(3) cDNA(24) Primer pair(3) Other(2)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000027813 (Evidence)
Ensembl Gene ModelENSMUSG00000027660 (Evidence)
Entrez Gene20482 (Evidence)
DFCITC1584243, TC1588644, TC1591305, TC1596725, TC1602782, TC1624370, TC1704279
DoTSDT.530726, DT.87049545
NIA Mouse Gene IndexU003115
Consensus CDS ProjectCCDS38408.1, CCDS50886.1, CCDS71230.1
International Mouse Knockout Project StatusSkil
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027813 VEGA Gene Model | MGI Sequence Detail 27520 C57BL/6J ±  kb
transcript OTTMUST00000068833 VEGA | MGI Sequence Detail 2904 Not Applicable 
polypeptide OTTMUSP00000034877 VEGA | MGI Sequence Detail 675 Not Applicable 

For the selected sequences
All sequences(71) RefSeq(8) UniProt(7)
Polymorphisms
SNPs within 2kb(178 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR014890 c-SKI SMAD4-binding domain
InterPro IPR009061 DNA binding domain, putative
InterPro IPR010919 SAND domain-like
InterPro IPR023216 Transcription regulator SKI/SnoN
InterPro IPR003380 Transforming protein Ski
Protein Ontology PR:000014906 ski-like protein
References
(Earliest) J:28741 Pearson-White S, et al., The ski/sno protooncogene family in hematopoietic development. Blood. 1995 Sep 15;86(6):2146-55
(Latest) J:201739 Zhu Q, et al., SnoN facilitates ALK1-Smad1/5 signaling during embryonic angiogenesis. J Cell Biol. 2013 Sep 16;202(6):937-50
All references(53)
Other
accession IDs
MGD-MRK-33894, MGI:1918865

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory