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Skil
Gene Detail
Symbol

Name
ID
Skil
SKI-like
MGI:106203
Synonyms
9130011J04Rik, Skir, sno-dE3, SnoN, SnoN2
Feature Type
protein coding gene
Genetic Map
Chromosome 3
15.12 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr3:31095058-31122573 bp, + strand
From VEGA annotation of GRCm38

  27516 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3948  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SKIL
Protein SuperFamily: ski transforming protein
Gene Tree: Skil

Human
homologs
SKIL, SKI-like proto-oncogene
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 6498
neXtProt AC: NX_P12757

Human Synonyms: SNO, SnoA, SnoI, SnoN

Human Chr (Location): 3q26; chr3:170357678-170396849 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(48) : Gene trapped(42) Targeted(6)
Incidental mutations (data from CvDC )
 
Mice which carry at least one allele for a disruption in this gene display abnomalities in their lymphocytes. Results with respect to embryonic lethality are inconsistent among the various allelic disruptions of this gene.
 
Interactions
Skil interacts with 415 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (37 annotations)
Process blastocyst formation, cell cycle arrest, ...
Component acrosomal vesicle, cytoplasm, ...
Function chromatin binding, protein binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (101)    Tissues (66)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 67
Northern blot 10
Western blot 4
RT-PCR 20
cDNA source data(22)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase skil    NEW 
Molecular
reagents
All nucleic(32) Genomic(3) cDNA(24) Primer pair(3) Other(2)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000027813 (Evidence)
Ensembl Gene Model ENSMUSG00000027660 (Evidence)
Entrez Gene 20482 (Evidence)
DFCI TC1602782, TC1596725, TC1591305, TC1588644, TC1584243, TC1624370, TC1704279
DoTS DT.530726, DT.87049545
NIA Mouse Gene Index U003115
Consensus CDS Project CCDS38408.1, CCDS50886.1, CCDS71230.1
International Mouse Phenotyping Consortium Status Skil
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027813 VEGA Gene Model | MGI Sequence Detail 27516 C57BL/6J ±  kb
transcript OTTMUST00000068833 VEGA | MGI Sequence Detail 2904 Not Applicable 
polypeptide OTTMUSP00000034877 VEGA | MGI Sequence Detail 675 Not Applicable 

For the selected sequences
All sequences(71) RefSeq(8) UniProt(7)
Polymorphisms
SNPs within 2kb(178 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR014890 c-SKI SMAD4-binding domain
InterPro IPR009061 DNA binding domain, putative
InterPro IPR010919 SAND domain-like
InterPro IPR023216 Transcription regulator SKI/SnoN
InterPro IPR003380 Transforming protein Ski
Protein Ontology PR:000014906 ski-like protein
References
(Earliest) J:28741 Pearson-White S, et al., The ski/sno protooncogene family in hematopoietic development. Blood. 1995 Sep 15;86(6):2146-55
(Latest) J:201739 Zhu Q, et al., SnoN facilitates ALK1-Smad1/5 signaling during embryonic angiogenesis. J Cell Biol. 2013 Sep 16;202(6):937-50
All references(52)
Other
accession IDs
MGD-MRK-33894, MGI:1918865

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory