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Vegfb
Gene Detail
Symbol

Name
ID
Vegfb
vascular endothelial growth factor B
MGI:106199
Synonyms
VEGF-B, Vrf
Feature Type
protein coding gene
Genetic Map
Chromosome 19
5.12 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr19:6982473-6987651 bp, - strand
From VEGA annotation of GRCm38

  5179 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:87131  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: VEGFB
Gene Tree: Vegfb

Human
homologs
VEGFB, vascular endothelial growth factor B
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 7423
neXtProt AC: NX_P49765

Human Synonyms: VEGFL, VRF

Human Chr (Location): 11q13; chr11:64234584-64239264 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(9) Targeted(5)
Incidental mutations (data from APF , CvDC )
 
Mice homozygous for disruptions in this gene display cardiac defects, such as atrial conduction abnormalities, smaller hearts, coronary vasculature anomalies and impaired recovery from induced cardiac ischemia, and fail to develop pulmonary hypertension in response to chronic hypoxia.
 
Interactions
Vegfb interacts with 89 markers (Mir10b, Mir15b, Mir23b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process angiogenesis, cardiac muscle contraction, ...
Component extracellular region, extracellular space, ...
Function chemoattractant activity, growth factor activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (30 records)
Data Summary: Results (123)    Tissues (69)    Images (10)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 29
RT-PCR 94
cDNA source data(40)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100487116    NEW 
Molecular
reagents
All nucleic(46) Genomic(2) cDNA(40) Primer pair(2) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000033015 (Evidence)
Ensembl Gene Model ENSMUSG00000024962 (Evidence)
Entrez Gene 22340 (Evidence)
UniGene 15607
DFCI TC1589142, TC1579674
DoTS DT.101372311, DT.531995
NIA Mouse Gene Index U038668
Consensus CDS Project CCDS29516.1, CCDS50373.1
International Mouse Phenotyping Consortium Status Vegfb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033015 VEGA Gene Model | MGI Sequence Detail 5179 C57BL/6J ±  kb
transcript OTTMUST00000082366 VEGA | MGI Sequence Detail 1281 Not Applicable 
polypeptide OTTMUSP00000044141 VEGA | MGI Sequence Detail 207 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(9 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023581 Platelet-derived growth factor, conserved site
InterPro IPR000072 Platelet-derived growth factor (PDGF)
Protein Ontology PR:000003096 vascular endothelial growth factor B
References
(Earliest) J:31999 Lagercrantz J, et al., Expression of the VEGF-related factor gene in pre- and postnatal mouse. Biochem Biophys Res Commun. 1996 Mar 7;220(1):147-52
(Latest) J:216730 Guaiquil VH, et al., VEGF-B selectively regenerates injured peripheral neurons and restores sensory and trophic functions. Proc Natl Acad Sci U S A. 2014 Dec 2;111(48):17272-7
All references(82)
Other
accession IDs
MGD-MRK-33890

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory