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Vegfb Gene Detail
Summary
  • Symbol
    Vegfb
  • Name
    vascular endothelial growth factor B
  • Synonyms
    VEGF-B, Vrf
  • Feature Type
    protein coding gene
  • IDs
    MGI:106199
    NCBI Gene: 22340
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:6982473-6987651 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 5.12 cM, cytoband B
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    9 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106199
protein coding gene Chr19:6982472-6987651 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024777
protein coding gene Chr19:4076349-4083046 (-)
A/J MGP_AJ_G0024744
protein coding gene Chr19:3745784-3751279 (-)
AKR/J MGP_AKRJ_G0024717
protein coding gene Chr19:3869797-3874906 (-)
BALB/cJ MGP_BALBcJ_G0024744
protein coding gene Chr19:3855114-3860304 (-)
C3H/HeJ MGP_C3HHeJ_G0024512
protein coding gene Chr19:3991967-3997170 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025190
protein coding gene Chr19:4171383-4176492 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022624
protein coding gene Chr19:3652142-3657542 (-)
CAST/EiJ MGP_CASTEiJ_G0023984
protein coding gene Chr19:3899181-3905689 (-)
CBA/J MGP_CBAJ_G0024484
protein coding gene Chr19:4221064-4228916 (-)
DBA/2J MGP_DBA2J_G0024611
protein coding gene Chr19:3717553-3722657 (-)
FVB/NJ MGP_FVBNJ_G0024576
protein coding gene Chr19:3747687-3752850 (-)
LP/J MGP_LPJ_G0024697
protein coding gene Chr19:3940500-3945625 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024606
protein coding gene Chr19:4129486-4135854 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025238
protein coding gene Chr19:4002211-4008990 (-)
PWK/PhJ MGP_PWKPhJ_G0023730
protein coding gene Chr19:3761615-3766762 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023534
protein coding gene Chr19:3821336-3826413 (-)
WSB/EiJ MGP_WSBEiJ_G0024046
protein coding gene Chr19:3905763-3911934 (-)



Homology
more
  • Human Ortholog
    VEGFB, vascular endothelial growth factor B
  • Vertebrate Orthologs
    7
  • Human Ortholog
    VEGFB, vascular endothelial growth factor B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    VEGFL, VRF
  • Links
    NCBI Gene ID: 7423
    neXtProt AC: NX_P49765
    UniProt: P49765

  • Chr Location
    11q13.1; chr11:64234584-64239264 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 4 alleles in 4 genetic backgrounds
    2 phenotypes from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for one or more disruptions in this gene display defective cardiac morphology and physiology, sensitivity to induced neurodegeneration, increased weight and brown adipose whitening.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024962 Ensembl Gene Model | MGI Sequence Detail 5179 C57BL/6J ±  kb
    transcript ENSMUST00000025914 Ensembl | MGI Sequence Detail 1281 Not Applicable  
    polypeptide ENSMUSP00000025914 Ensembl | MGI Sequence Detail 207 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 50
      Genomic 2
      cDNA 42
      Primer pair 4
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-33890
    References
    more
    • Summaries
      All 103
      Developmental Gene Expression 36
      Gene Ontology 7
      Phenotypes 25
    • Earliest
      J:31999 Lagercrantz J, et al., Expression of the VEGF-related factor gene in pre- and postnatal mouse. Biochem Biophys Res Commun. 1996 Mar 7;220(1):147-52
    • Latest
      J:261397 Jin H, et al., VEGF and VEGFB Play Balancing Roles in Adipose Differentiation, Gene Expression, and Function. Endocrinology. 2018 May 1;159(5):2036-2049

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory