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Vegfb Gene Detail
Summary
  • Symbol
    Vegfb
  • Name
    vascular endothelial growth factor B
  • Synonyms
    VEGF-B, Vrf
  • Feature Type
    protein coding gene
  • IDs
    MGI:106199
    NCBI Gene: 22340
Location & Maps
more
  • Genetic Map
    Chromosome 19, 5.12 cM, cytoband B
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    VEGFB, vascular endothelial growth factor B
  • Vertebrate Orthologs
    7
  • Human Ortholog
    VEGFB, vascular endothelial growth factor B
    Orthology source: HGNC, HomoloGene
  • Synonyms
    VEGFL, VRF
  • Links
    NCBI Gene ID: 7423
    neXtProt AC: NX_P49765

  • Chr Location
    11q13; chr11:64234584-64239264 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 3 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    15
  • Gene trapped
    9
  • Targeted
    5
  • Transgenic
    1
  • Incidental Mutations
    APF , CvDC
Mice homozygous for disruptions in this gene display cardiac defects, such as atrial conduction abnormalities, smaller hearts, coronary vasculature anomalies and impaired recovery from induced cardiac ischemia, and fail to develop pulmonary hypertension in response to chronic hypoxia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033015 VEGA Gene Model | MGI Sequence Detail 5179 C57BL/6J ±  kb
transcript OTTMUST00000082366 VEGA | MGI Sequence Detail 1281 Not Applicable  
polypeptide OTTMUSP00000044141 VEGA | MGI Sequence Detail 207 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    9 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000003096 vascular endothelial growth factor B
  • InterPro Domains
    IPR029034 Cystine-knot cytokine
    IPR000072 PDGF/VEGF domain
    IPR023581 Platelet-derived growth factor, conserved site
Molecular
Reagents
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  • All nucleic 48
    Genomic 2
    cDNA 41
    Primer pair 3
    Other 2

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-33890
References
more
  • Summaries
    All 81
    Developmental Gene Expression 32
    Gene Ontology 4
    Phenotypes 21
  • Earliest
    J:31999 Lagercrantz J, et al., Expression of the VEGF-related factor gene in pre- and postnatal mouse. Biochem Biophys Res Commun. 1996 Mar 7;220(1):147-52
  • Latest
    J:232444 Li S, et al., Ggnbp2 Is Essential for Pregnancy Success via Regulation of Mouse Trophoblast Stem Cell Proliferation and Differentiation. Biol Reprod. 2016 Feb;94(2):41

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory