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Ocln Gene Detail
Summary
  • Symbol
    Ocln
  • Name
    occludin
  • Synonyms
    Ocl
  • Feature Type
    protein coding gene
  • IDs
    MGI:106183
    NCBI Gene: 18260
  • Gene Overview
    MyGene.info: OCLN
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr13:100496507-100552718 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      56212 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 53.23 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    OCLN, occludin
  • Vertebrate Orthologs
    9
  • Human Ortholog
    OCLN, occludin
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BLCPMG, PPP1R115, PTORCH1
  • Links
    NCBI Gene ID: 100506658
    neXtProt AC: NX_Q16625
    UniProt: Q16625

  • Chr Location
    chr5:69492292-69558104 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 1905
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: OCLN
  • Protein SuperFamily
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human OCLN associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 5 alleles in 4 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display gastritis, loss of gastric parietal and chief cells, gastric mucus cell hyperplasia, reduced gastric acid secretion, growth retardation, male infertility, seminiferous tubule atrophy, failure to nurse pups, mineral deposits in the brain, and thinning of the compact bone.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000035055 VEGA Gene Model | MGI Sequence Detail 56212 C57BL/6J ±  kb
    transcript OTTMUST00000089160 VEGA | MGI Sequence Detail 4052 Not Applicable  
    polypeptide OTTMUSP00000048684 VEGA | MGI Sequence Detail 521 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      302 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      Genomic 8
      cDNA 11
      Primer pair 4

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-33873, MGI:2145262
    References
    more
    • Summaries
      All 156
      Developmental Gene Expression 76
      Gene Ontology 25
      Phenotypes 18
    • Earliest
      J:32229 Ando-Akatsuka Y, et al., Interspecies diversity of the occludin sequence: cDNA cloning of human, mouse, dog, and rat-kangaroo homologues. J Cell Biol. 1996 Apr;133(1):43-7
    • Latest
      J:251744 Zega K, et al., Dusp16 Deficiency Causes Congenital Obstructive Hydrocephalus and Brain Overgrowth by Expansion of the Neural Progenitor Pool. Front Mol Neurosci. 2017;10(None):372

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    Funding Information
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    last database update
    05/08/2018
    MGI 6.12
    The Jackson Laboratory