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Ocln Gene Detail
Summary
  • Symbol
    Ocln
  • Name
    occludin
  • Synonyms
    Ocl
  • Feature Type
    protein coding gene
  • IDs
    MGI:106183
    NCBI Gene: 18260
  • Gene Overview
    MyGene.info: OCLN
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:100496507-100552718 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 53.23 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    302 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106183
protein coding gene Chr13:100496504-100553691 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020886
protein coding gene Chr13:102418803-102473949 (-)
A/J MGP_AJ_G0020838
protein coding gene Chr13:98436688-98493745 (-)
AKR/J MGP_AKRJ_G0020813
protein coding gene Chr13:101465520-101521572 (-)
BALB/cJ MGP_BALBcJ_G0020837
protein coding gene Chr13:99169291-99222755 (-)
C3H/HeJ MGP_C3HHeJ_G0020627
protein coding gene Chr13:101176086-101229607 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021271
protein coding gene Chr13:105464277-105520332 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018842
protein coding gene Chr13:94272039-94325163 (-)
CAST/EiJ MGP_CASTEiJ_G0020146
protein coding gene Chr13:100620555-100686208 (-)
CBA/J MGP_CBAJ_G0020588
protein coding gene Chr13:109623219-109686596 (-)
DBA/2J MGP_DBA2J_G0020713
protein coding gene Chr13:98223516-98279450 (-)
FVB/NJ MGP_FVBNJ_G0020694
protein coding gene Chr13:96963905-97017384 (-)
LP/J MGP_LPJ_G0020787
protein coding gene Chr13:102441528-102495344 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020723
protein coding gene Chr13:109887009-109943548 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021311
protein coding gene Chr13:100911579-100972515 (-)
PWK/PhJ MGP_PWKPhJ_G0019899
protein coding gene Chr13:96934543-96993116 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019721
protein coding gene Chr13:97142654-97200883 (-)
WSB/EiJ MGP_WSBEiJ_G0020203
protein coding gene Chr13:101376472-101434899 (-)



Homology
more
  • Human Ortholog
    OCLN, occludin
  • Vertebrate Orthologs
    9
  • Human Ortholog
    OCLN, occludin
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BLCPMG, PPP1R115, PTORCH1
  • Links
    NCBI Gene ID: 100506658
    neXtProt AC: NX_Q16625
    UniProt: Q16625

  • Chr Location
    chr5:69492292-69558104 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 1905
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: OCLN
  • Protein SuperFamily
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human OCLN associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 5 alleles in 4 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display gastritis, loss of gastric parietal and chief cells, gastric mucus cell hyperplasia, reduced gastric acid secretion, growth retardation, male infertility, seminiferous tubule atrophy, failure to nurse pups, mineral deposits in the brain, and thinning of the compact bone.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021638 Ensembl Gene Model | MGI Sequence Detail 56212 C57BL/6J ±  kb
    transcript ENSMUST00000069756 Ensembl | MGI Sequence Detail 4052 Not Applicable  
    polypeptide ENSMUSP00000065284 Ensembl | MGI Sequence Detail 521 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      Genomic 8
      cDNA 12
      Primer pair 4

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-33873, MGI:2145262
    References
    more
    • Summaries
      All 161
      Developmental Gene Expression 81
      Gene Ontology 24
      Phenotypes 19
    • Earliest
      J:32229 Ando-Akatsuka Y, et al., Interspecies diversity of the occludin sequence: cDNA cloning of human, mouse, dog, and rat-kangaroo homologues. J Cell Biol. 1996 Apr;133(1):43-7
    • Latest
      J:261068 Szabo R, et al., Loss of HAI-2 in mice with decreased prostasin activity leads to an early-onset intestinal failure resembling congenital tufting enteropathy. PLoS One. 2018;13(4):e0194660

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory