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Ocln
Gene Detail
Symbol

Name
ID
Ocln
occludin
MGI:106183
Synonyms
Ocl
Feature Type
protein coding gene
Genetic Map
Chromosome 13
53.23 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr13:100496507-100552718 bp, - strand
From VEGA annotation of GRCm38

  56212 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1905  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: OCLN
Protein SuperFamily: occludin
Gene Tree: Ocln

Human
homologs
OCLN, occludin
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 100506658
neXtProt AC: NX_Q16625

Human Synonyms: BLCPMG, PPP1R115

Human Chr (Location): chr5:69492292-69558104 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human OCLN

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(2) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display gastritis, loss of gastric parietal and chief cells, gastric mucus cell hyperplasia, reduced gastric acid secretion, growth retardation, male infertility, seminiferous tubule atrophy, failure to nurse pups, mineral deposits in the brain, and thinning of the compact bone.
 
Interactions
Ocln interacts with 286 markers (Mir1a-1, Mir1b, Mir7-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (67 records)
Data Summary: Results (215)    Tissues (157)    Images (29)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 15
RNA in situ 93
Western blot 7
RT-PCR 100
cDNA source data(11)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ocln    NEW 
Molecular
reagents
All nucleic(23) Genomic(8) cDNA(11) Primer pair(4)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000035055 (Evidence)
Ensembl Gene Model ENSMUSG00000021638 (Evidence)
Entrez Gene 18260 (Evidence)
DFCI TC1578847, TC1659799
DoTS DT.101267042, DT.101382080, DT.40151044, DT.50314967
NIA Mouse Gene Index U035109, U296763
Consensus CDS Project CCDS26731.1
International Mouse Phenotyping Consortium Status Ocln
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035055 VEGA Gene Model | MGI Sequence Detail 56212 C57BL/6J ±  kb
transcript OTTMUST00000089160 VEGA | MGI Sequence Detail 4052 Not Applicable 
polypeptide OTTMUSP00000048684 VEGA | MGI Sequence Detail 521 Not Applicable 

For the selected sequences
All sequences(57) RefSeq(10) UniProt(5)
Polymorphisms
SNPs within 2kb(309 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008253 Marvel
InterPro IPR002958 Occludin
InterPro IPR010844 Occludin/RNA polymerase II elongation factor, ELL domain
Protein Ontology PR:000002207 occludin
References
(Earliest) J:32229 Ando-Akatsuka Y, et al., Interspecies diversity of the occludin sequence: cDNA cloning of human, mouse, dog, and rat-kangaroo homologues. J Cell Biol. 1996 Apr;133(1):43-7
(Latest) J:216221 Kitajiri S, et al., Deafness in occludin-deficient mice with dislocation of tricellulin and progressive apoptosis of the hair cells. Biol Open. 2014;3(8):759-66
All references(130)
Other
accession IDs
MGD-MRK-33873, MGI:2145262

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory