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Ocln
Gene Detail
Symbol

Name
ID
Ocln
occludin
MGI:106183
Synonyms
Ocl
Feature Type
protein coding gene
Genetic Map
Chromosome 13
53.23 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr13:100496507-100552718 bp, - strand
From VEGA annotation of GRCm38

  56212 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1905  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: occludin
Gene Tree: Ocln

Human
homologs
Human Homolog OCLN, occludin
NCBI Gene ID 100506658
neXtProt AC  NX_Q16625
Human Synonyms  BLCPMG, PPP1R115
Human Chr (Location)  chr5:69492292-69558104 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human OCLN
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(2) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display gastritis, loss of gastric parietal and chief cells, gastric mucus cell hyperplasia, reduced gastric acid secretion, growth retardation, male infertility, seminiferous tubule atrophy, failure to nurse pups, mineral deposits in the brain, and thinning of the compact bone.
 
Interactions
Ocln interacts with 287 markers (Mir1a-1, Mir1b, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process cell-cell junction organization, methylation, ...
Component apical plasma membrane, apicolateral plasma membrane, ...
Function protein binding, protein domain specific binding, ...
External Resources: FuncBase
Expression
Literature Summary: (66 records)
Data Summary: Results (213)    Tissues (157)    Images (27)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 13
RNA in situ 93
Western blot 7
RT-PCR 100
cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(23) Genomic(8) cDNA(11) Primer pair(4)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000035055 (Evidence)
Ensembl Gene ModelENSMUSG00000021638 (Evidence)
Entrez Gene18260 (Evidence)
DFCITC1659799, TC1578847
DoTSDT.101267042, DT.40151044, DT.50314967, DT.101382080
NIA Mouse Gene IndexU296763, U035109
Consensus CDS ProjectCCDS26731.1
International Mouse Knockout Project StatusOcln
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035055 VEGA Gene Model | MGI Sequence Detail 56212 C57BL/6J ±  kb
transcript OTTMUST00000089160 VEGA | MGI Sequence Detail 4052 Not Applicable 
polypeptide OTTMUSP00000048684 VEGA | MGI Sequence Detail 521 Not Applicable 

For the selected sequences
All sequences(61) RefSeq(10) UniProt(9)
Polymorphisms
SNPs within 2kb(309 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008253 Marvel
InterPro IPR002958 Occludin
InterPro IPR010844 Occludin/RNA polymerase II elongation factor, ELL domain
Protein Ontology PR:000002207 occludin
References
(Earliest) J:32229 Ando-Akatsuka Y, et al., Interspecies diversity of the occludin sequence: cDNA cloning of human, mouse, dog, and rat-kangaroo homologues. J Cell Biol. 1996 Apr;133(1):43-7
(Latest) J:208053 Kopecki Z, et al., Flightless I over-expression impairs skin barrier development, function and recovery following skin blistering. J Pathol. 2014 Apr;232(5):541-52
All references(129)
Other
accession IDs
MGD-MRK-33873, MGI:2145262

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory