Ocln
Gene Detail

Symbol Name ID

Ocln occludin MGI:106183

Synonyms

Ocl

Feature Type

protein coding gene

Genetic Map

Chromosome 13

53.23 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr13:100496507-100552718 bp, - strand From VEGA annotation of GRCm38   56212 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1905  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: occludin
Gene Tree: Ocln

Human homologs

Human Homolog		OCLN, occludin
NCBI Gene ID		100506658
neXtProt AC		NX_Q16625
Human Synonyms		BLCPMG
Human Chr (Location)		chr5:68788119-68853931 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human OCLN

Alleles and phenotypes

All alleles(7) : Targeted(5) Gene trapped(2)
 

Homozygous null mice display gastritis, loss of gastric parietal and chief cells, gastric mucus cell hyperplasia, reduced gastric acid secretion, growth retardation, male infertility, seminiferous tubule atrophy, failure to nurse pups, mineral deposits in the brain, and thinning of the compact bone.

 

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	cell-cell junction organization, S-adenosylhomocysteine metabolic process, ...
Component	apical plasma membrane, apicolateral plasma membrane, ...
Function	protein binding, S-adenosylmethionine-dependent methyltransferase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (56 records)
Data Summary: Results (214)    Tissues (159)    Images (27)
Theiler Stages: 2, 4, 5, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	14
RNA in situ	93
Western blot	7
RT-PCR	100

cDNA source data(11)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(23) Genomic(8) cDNA(11) Primer pair(4)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000035055 (Evidence)
Ensembl Gene Model	ENSMUSG00000021638 (Evidence)
Entrez Gene	18260 (Evidence)
DFCI	TC1578847, TC1659799
DoTS	DT.101267042, DT.101382080, DT.40151044, DT.50314967
NIA Mouse Gene Index	U035109, U296763
Consensus CDS Project	CCDS26731.1
International Mouse Knockout Project Status	Ocln

Sequences

Length	Strain/Species
genomic	OTTMUSG00000035055	VEGA Gene Model | MGI Sequence Detail	56212	C57BL/6J
transcript	OTTMUST00000089160	VEGA | MGI Sequence Detail	4052	Not Applicable
polypeptide	OTTMUSP00000048684	VEGA | MGI Sequence Detail	521	Not Applicable

All sequences(49) RefSeq(2) UniProt(5)

Polymorphisms

SNPs(277 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008253	Marvel
InterPro	IPR021128	MARVEL-like domain
InterPro	IPR002958	Occludin
InterPro	IPR010844	Occludin/RNA polymerase II elongation factor, ELL domain
Protein Ontology	PR:000002207	occludin

References

(Earliest) J:32229 Ando-Akatsuka Y, et al., Interspecies diversity of the occludin sequence: cDNA cloning of human, mouse, dog, and rat-kangaroo homologues. J Cell Biol. 1996 Apr;133(1):43-7
(Latest) J:190580 Lei Z, et al., EpCAM contributes to formation of functional tight junction in the intestinal epithelium by recruiting claudin proteins. Dev Biol. 2012 Nov 15;371(2):136-45
All references(115)

Other accession IDs

MGD-MRK-33873, MGI:2145262