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Ocln Gene Detail
Summary
  • Symbol
    Ocln
  • Name
    occludin
  • Synonyms
    Ocl
  • Feature Type
    protein coding gene
  • IDs
    MGI:106183
    NCBI Gene: 18260
  • Gene Overview
    MyGene.info: OCLN
Location & Maps
more
  • Sequence Map
    Chr13:100496507-100552718 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      56212 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    OCLN, occludin
  • Vertebrate Orthologs
    9
  • Human Ortholog
    OCLN, occludin
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BLCPMG, PPP1R115
  • Links
    NCBI Gene ID: 100506658
    neXtProt AC: NX_Q16625

  • Chr Location
    chr5:69492292-69558104 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human OCLN associations

Human Disease Mouse Models
       Band-Like Calcification with Simplified Gyration and Polymicrogyria;   OMIM: 251290
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 5 alleles in 4 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Gene trapped
    2
  • Targeted
    5
  • Transgenic
    1
  • Incidental Mutations
Homozygous null mice display gastritis, loss of gastric parietal and chief cells, gastric mucus cell hyperplasia, reduced gastric acid secretion, growth retardation, male infertility, seminiferous tubule atrophy, failure to nurse pups, mineral deposits in the brain, and thinning of the compact bone.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035055 VEGA Gene Model | MGI Sequence Detail 56212 C57BL/6J ±  kb
transcript OTTMUST00000089160 VEGA | MGI Sequence Detail 4052 Not Applicable  
polypeptide OTTMUSP00000048684 VEGA | MGI Sequence Detail 521 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    302 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 23
    Genomic 8
    cDNA 11
    Primer pair 4

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-33873, MGI:2145262
References
more
  • Summaries
    All 129
    Developmental Gene Expression 70
    Gene Ontology 22
    Phenotypes 15
  • Earliest
    J:32229 Ando-Akatsuka Y, et al., Interspecies diversity of the occludin sequence: cDNA cloning of human, mouse, dog, and rat-kangaroo homologues. J Cell Biol. 1996 Apr;133(1):43-7
  • Latest
    J:227364 Sohet F, et al., LSR/angulin-1 is a tricellular tight junction protein involved in blood-brain barrier formation. J Cell Biol. 2015 Mar 16;208(6):703-11

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory