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Shc2
Gene Detail
 Symbol
Name
ID
Shc2
SHC (Src homology 2 domain containing) transforming protein 2
MGI:106180
Synonyms ShcB, Sli
Feature Type protein coding gene
Genetic Map
Chromosome 10
39.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr10:79618051-79637918 bp, - strand
From VEGA annotation of GRCm38

  19868 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:19127  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: SHC-transforming protein
Gene Tree: Shc2

Human
homologs
Human Homolog SHC2, SHC (Src homology 2 domain containing) transforming protein 2
NCBI Gene ID 25759
neXtProt AC  NX_P98077
Human Synonyms  SCK, SHCB, SLI
Human Chr (Location)  19p13.3; chr19:416583-460996 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display sensory nerve defects related to nociception.
 
Interactions
Shc2 interacts with 217 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (1 annotations)
Process intracellular signal transduction
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (220)    Tissues (55)    Images (31)
Theiler Stages: 19, 20, 21, 22, 23, 24, 26, 27, 28
Assay TypeResults
Immunohistochemistry 14
RNA in situ 176
Western blot 20
RT-PCR 10
cDNA source data(29)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(33) Genomic(1) cDNA(31) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000036889 (Evidence)
Ensembl Gene ModelENSMUSG00000020312 (Evidence)
Entrez Gene216148 (Evidence)
UniGene39424
DFCITC1602724, TC1622143, TC1643944, TC1685543, TC1690152
DoTSDT.101226192, DT.480813, DT.60108520, DT.91289915, DT.94171078
NIA Mouse Gene IndexU031987
Consensus CDS ProjectCCDS48620.1
International Mouse Knockout Project StatusShc2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036889 VEGA Gene Model | MGI Sequence Detail 19868 C57BL/6J ±  kb
transcript OTTMUST00000094770 VEGA | MGI Sequence Detail 3243 Not Applicable 
polypeptide OTTMUSP00000052781 VEGA | MGI Sequence Detail 438 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(3) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(17 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006020 Phosphotyrosine interaction domain
InterPro IPR006019 Phosphotyrosine interaction (PID/PI)
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR000980 SH2 domain
Protein Ontology PR:000003180 SHC-transforming protein 2
References (Earliest) J:32205 O'Bryan JP, et al., A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain. Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):2729-34
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(34)
Other
accession IDs
MGD-MRK-33870

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory