Shc2
Gene Detail

Symbol Name ID

Shc2 SHC (Src homology 2 domain containing) transforming protein 2 MGI:106180

Synonyms

ShcB, Sli

Feature Type

protein coding gene

Genetic Map

Chromosome 10

39.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr10:79618051-79637918 bp, - strand From VEGA annotation of GRCm38   19868 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:19127  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: SHC-transforming protein
Gene Tree: Shc2

Human homologs

Human Homolog		SHC2, SHC (Src homology 2 domain containing) transforming protein 2
NCBI Gene ID		25759
neXtProt AC		NX_P98077
Human Synonyms		SCK, SHCB, SLI
Human Chr (Location)		19p13.3; chr19:416583-460996 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mice homozygous for disruptions in this gene display sensory nerve defects related to nociception.

 

Gene Ontology (GO) classifications

All GO classifications: (1 annotations)

Process

intracellular signal transduction

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (220)    Tissues (54)    Images (31)
Theiler Stages: 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	14
RNA in situ	176
Western blot	20
RT-PCR	10

cDNA source data(29)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(33) Genomic(1) cDNA(31) Primer pair(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000036889 (Evidence)
Ensembl Gene Model	ENSMUSG00000020312 (Evidence)
Entrez Gene	216148 (Evidence)
UniGene	39424
DFCI	TC1602724, TC1622143, TC1643944, TC1685543, TC1690152
DoTS	DT.101226192, DT.480813, DT.60108520, DT.91289915, DT.94171078
NIA Mouse Gene Index	U031987
Consensus CDS Project	CCDS48620.1
International Mouse Knockout Project Status	Shc2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000036889	VEGA Gene Model | MGI Sequence Detail	19868	C57BL/6J
transcript	OTTMUST00000094770	VEGA | MGI Sequence Detail	3243	Not Applicable
polypeptide	OTTMUSP00000052781	VEGA | MGI Sequence Detail	438	Not Applicable

All sequences(36) RefSeq(3) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(15 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006020	Phosphotyrosine interaction domain
InterPro	IPR006019	Phosphotyrosine interaction (PID/PI)
InterPro	IPR011993	Pleckstrin homology-like domain
InterPro	IPR000980	SH2 domain
Protein Ontology	PR:000003180	shc-transforming protein 2

References

(Earliest) J:32205 O'Bryan JP, et al., A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain. Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):2729-34
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(34)

Other accession IDs

MGD-MRK-33870